期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 35, 期 20, 页码 1776-1781出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201400308
关键词
micelles; self-assembly; stimuli-sensitive polymers; supramolecular structures
资金
- National Key Technology RD Program [2012BAI15B061]
- National Basic Research Program of China (973 Program) [2011CB013805]
- National High Technology Research and Development Program of China [2013AA032202]
A supramolecular block copolymer is prepared by the molecular recognition of nucleobases between poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate)-SS-poly(epsilon-caprolactone)-adenine (P(MEO(2)MA-co-OEGMA)-SS-PCL-A) and uracil-terminated poly(ethylene glycol) (PEG-U). Because the block copolymer is linked by the combination of covalent (disulfide bond) and noncovalent (AU) bonds, it not only has similar properties to conventional covalently linked block copolymers but also possesses a dynamic and tunable nature. The copolymer can self-assemble into micelles with a PCL core and P(MEO(2)MA-co-OEGMA)/PEG shell. The size and morphologies of the micelles/aggregates can be adjusted by altering the temperature, pH, salt concentration, or adding dithiothreitol (DTT) to the solution. The controlled release of Nile red is achieved at different environmental conditions.
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