期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 33, 期 17, 页码 1459-1465出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201200343
关键词
biomaterials; biomolecules; coatings; immobilization; surface engineering
资金
- Army Research Office (ARO) [W911NF-11-1-0251]
A multifunctional copolymer with both aldehyde and alkyne groups is synthesized by chemical vapor deposition (CVD) for orthogonal co-immobilization of biomolecules. Surface analytical methods including FTIR and XPS are used to confirm the surface modification. Heparin-binding growth factors [basic fibroblast growth factor (bFGF) in this study] can be immobilized through interaction with heparin, which was covalently attached to the CVD surface through an aldehyde-hydrazide reaction. In parallel, an alkyneazide reaction is used to orthogonally co-immobilize an adhesion peptide as the second biomolecule.
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