期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 29, 期 23, 页码 1895-1901出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200800300
关键词
block copolymers; controlled release; hollow spherical micelles; hydrogen bonding; hydrophilic channel; ibuprofen
资金
- National Natural Science Foundation of China [20774051, 50830103]
- Outstanding Youth Fund [50625310]
- Opening Project of State Key Laboratory of Polymer Materials Engineering (Sichuan University)
PS-b-PAA spherical micelles with a liquid core and a PAA shell are prepared with the assistance of 1,2-dichloroethane. During the process of adding a mixture of PNIPAM-b-P4VP and PEG-b-P4VP, multi-layered micelles with a mixed corona that consists of both PNIPAM and PEG chains are constructed through the electrostatic interaction and hydrogen bonding between the PAA block and the P4VP block. When heating above the LCST, the PNIPAM chains collapse onto the PAA/P4VP complex layer while the PEG chains still stretch into the solution through the collapsed PNIPAM layer, which leads to the formation of hydrophilic channels around the PEG, chains. The ibuprofen encapsulated in the hollow space can diffuse through the channels and its release rate can be controlled by changing the ratio of PEG chains to PNIPAM chains in the corona.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据