Article
Biochemistry & Molecular Biology
Sourour Idoudi, Takwa Bedhiafi, Fairooz Sahir, Yousef Hijji, Shahab Uddin, Maysaloun Merhi, Said Dermime, Nashiru Billa
Summary: This study evaluated the anti-cancer activity of curcumin nanoparticles (CUR-NPs) and succinylated curcumin nanoparticles (CUR.SA-NPs) on colon cancer cell lines. The nanoparticles showed dose and time-dependent cytotoxicity, inducing apoptosis through activation of Caspase signaling. Based on their promising attributes and in vitro results, further investigation into the role of these nanoparticle formulations in CRC management is warranted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Supakarn Hansapaiboon, Bryan Paul Bulatao, Feuangthit Niyamissara Sorasitthiyanukarn, Pongsakorn Jantaratana, Nonthaneth Nalinratana, Opa Vajragupta, Pranee Rojsitthisak, Pornchai Rojsitthisak
Summary: This study demonstrates the effectiveness of magnetic-guide targeting in delivering CUR-2GE-Ch-IONPs for the treatment of triple-negative breast cancer.
Article
Nanoscience & Nanotechnology
P. H. Nam, N. X. Phuc, D. H. Manh, D. K. Tung, V. Q. Nguyen, N. H. Nam, P. K. Son, T. N. Bach, P. T. Phong
Summary: Cobalt ferrite nanoparticles with three different grain sizes were successfully synthesized using a hydrothermal method, showing pure cubic spinel characteristics. The nanoparticles' magnetic and optical properties were studied, indicating their potential applications in magnetic hyperthermia therapy.
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2021)
Article
Chemistry, Physical
I. Anila, M. Jacob Mathew
Summary: In this study, single-phase cobalt ferrite nanocubes were successfully synthesized and modified with biocompatible polymer chitosan. The effect of chitosan coating on the structure, magnetic properties, and cytotoxicity of the nanoparticles was investigated using various characterization techniques. The results confirmed the successful coating of chitosan on the surface of CoFe2O4 nanoparticles and showed improved biocompatibility with reduced cytotoxicity compared to bare samples. Furthermore, the magnetic properties were analyzed and discussed in detail, revealing the ferromagnetic nature of the synthesized samples and the contribution of various magnetic phases.
APPLIED SURFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Wen Shen, Mengyao Yan, Shang Wu, Xuemei Ge, Shuxing Liu, Yan Du, Yan Zheng, Lixin Wu, Yue Zhang, Yueyang Mao
Summary: Curcumin nanoparticles were successfully prepared using chitosan nanoparticles as carrier, significantly improving the solubility and antioxidant capacity of curcumin. The edible coating prepared by combining curcumin nanoparticles with sodium carboxymethyl cellulose effectively inhibited lipid oxidation of fresh pork.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Duoduo Li, Zihao Wei, Jialin Sun, Changhu Xue
Summary: This study demonstrates that zein/TP NPs prepared by anti-solvent precipitation method can effectively stabilize curcumin and improve its retention and bioaccessibility. The addition of Tremella polysaccharide significantly enhances the stability and encapsulation efficiency of curcumin, making zein/TP NPs a potential and effective carrier for delivery purposes.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Chemistry, Physical
Celine Arab, Riham El Kurdi, Digambara Patra
Summary: Zinc curcumin oxide nanoparticles coated with chitosan were successfully synthesized and proved to be an excellent nanoprobe for detecting ascorbic acid. The nanoparticles showed high crystallinity and stability at high temperatures. The detection method based on fluorescence emission technique was found to be fast, stable, easy to manipulate, and selective with high recovery rates.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Agriculture, Multidisciplinary
Siyan Guo, Yanyan Zhao, Shuizhong Luo, Dongdong Mu, Xingjiang Li, Xiyang Zhong, Shaotong Jiang, Zhi Zheng
Summary: Gliadin nanoparticles stabilized by soluble soybean polysaccharide (SSPS) were prepared in this study and successfully encapsulated curcumin (Cur). The nanoparticles showed excellent stability and high delivery efficiency according to various tests and experiments.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Mian Huang, Ji Liu, Yu Fan, Jing Sun, Jiang-Xue Cheng, Xiao-Fei Zhang, Bing-Tao Zhai, Dong-Yan Guo
Summary: The study developed a novel CUR nanocarrier GC@NPs with superior targeting and biocompatibility, which efficiently released CUR for hepatocellular carcinoma treatment and showed promising anti-tumor effects in in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Xiaozhu Chen, Hong Zhang, Chu Wang, Yue Su, Min Xiong, Xiaohua Feng, Daishi Chen, Zhaoyang Ke, Lu Wen, Gang Chen
Summary: This study developed two nanoformulations of curcumin to protect against ototoxic hearing loss. The results showed that CUR-CS/PLGA NPs had the best protective effects, with sustained efficacy and hearing improvement, making it a promising candidate for alleviating sensorineural hearing loss.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
A. Abruzzo, B. Giordani, A. Miti, B. Vitali, G. Zuccheri, T. Cerchiara, B. Luppi, F. Bigucci
Summary: The study designed chitosan nanoparticles and evaluated their use as mucoadhesive and/or mucopenetrating systems for vancomycin delivery. The nanoparticles showed sizes ranging from 150 nm to 350 nm with good polydispersity index and positive zeta-potential, allowing for fast and complete release of vancomycin while maintaining antibacterial activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Instruments & Instrumentation
Ana Ortega, Ayana Bretas da Silva, Leidyana Moraes da Costa, Kelly Cristine Zatta, Giovana Ravizzoni Onzi, Francisco Noe da Fonseca, Silvia Staniscuaski Guterres, Karina Paese
Summary: This study proposes the development of a thermosensitive hydrogel containing curcumin-loaded lipid-core nanocapsules coated with chitosan for buccal drug administration. The results showed that the hydrogel exhibited higher mucoadhesion and a longer residence time on buccal mucosa compared to the nanocapsules in suspension. The proposed nanosystem also demonstrated effectiveness against oral squamous cancer cells.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mohamed Dawoud
Summary: Chitosan-coated solid lipid nanoparticles were successfully developed in this study, leading to an increase in particle size, change in surface charge, and slower release of docetaxel. These coated nanoparticles exhibited enhanced in vitro cytotoxicity and tumor inhibition compared to uncoated nanoparticles.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ali Mohammadi, Hossein Danafar
Summary: Cancer is a common cause of death worldwide and curcumin is a natural anticancer therapeutic with limited or no negative effects. However, its therapeutic applications are limited due to its hydrophobic nature and poor bioavailability. In this study, Bovine Serum Albumin-Coated Copper Sulfide nanoparticles were synthesized for curcumin drug delivery. The nanoparticles were characterized and their release pattern, hemotoxicity, and cytotoxicity were investigated. The results showed that the synthesized nanoparticles had a high CUR loading and its release was dependent on pH. The nanoparticles exhibited no toxicity and could be considered as a suitable candidate for drug delivery.
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Chandra Chiappin Cardoso, Camila Matiollo, Carolina Hilgert Jacobsen Pereira, Janaina Santana Fonseca, Helder Emmanuel Leite Alves, Otavio Marcos da Silva, Vivian de Souza Menegassi, Claudia Regina dos Santos, Ana Carolina Rabello de Moraes, Leonardo de Lucca Schiavon, Maria Claudia Santos-Silva
Summary: The study revealed significant disturbances in circulating monocytes and dendritic cells in cirrhotic patients, with unstable cirrhosis patients showing higher frequencies of specific cell subsets. These changes in cell subsets may be associated with disease severity and mortality rates.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Laura O. Walter, Mariana F. Maioral, Lisandra O. Silva, Douglas B. Speer, Sanjay C. Campbell, Winklet Gallimore, Miriam B. Falkenberg, Maria Claudia Santos-Silva
Summary: This study evaluated the cytotoxicity of the o-quinone stypoldione isolated from brown algae on multiple myeloma cells (MM) and found it to have potential for MM treatment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Immunology
Laura Otto Walter, Chandra Chiappin Cardoso, Iris Mattos Santos-Pirath, Heloisa Zorzi Costa, Rafaela Gartner, Isabel Werle, Eduarda Talita Bramorski Mohr, Julia Salvan da Rosa, Mariano Felisberto, Iara Fabricia Kretzer, Ivete Ioshiko Masukawa, Patricia de Almeida Vanny, Magali Chaves Luiz, Ana Carolina Rabello de Moraes, Eduardo Monguilhott Dalmarco, Maria Claudia Santos-Silva
Summary: This study aimed to evaluate the relationship between changes in the peripheral immune system and the severity of COVID-19. The results showed that alterations in neutrophils, monocytes, and dendritic cells were associated with immune dysregulation in COVID-19 patients. In addition, certain inflammatory mediators were found to be correlated with disease severity, with IL-10 showing potential as a prognostic biomarker for COVID-19.
Article
Pharmacology & Pharmacy
Paulo Emilio Feuser, Paula Christina Matos dos Santos, Arthur Poester Cordeiro, Natalia Marceli Stefanes, Laura Otto Walter, Mariana Franzoni Maioral, Maria Claudia Santos-Silva, Pedro Henrique Hermes de Araujo, Claudia Sayer
Summary: Encapsulation of 4NC in PTEe nanoparticles enhances cytotoxicity against leukemia cells while reducing damage to peripheral blood mononuclear cells, showing a higher selectivity index compared to free 4NC.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marcos Antonio Villetti, Adryana Rocha Clementino, Ilaria Dotti, Patricia Regina Ebani, Eride Quarta, Francesca Buttini, Fabio Sonvico, Annalisa Bianchera, Redouane Borsali
Summary: Nanoparticles of MH-b-PS@TMC obtained through standard nanoprecipitation method displayed small size, high encapsulation efficiency, and higher cytotoxicity towards MCF-7 cells, indicating their effectiveness as a delivery system for lipophilic anticancer drugs.
Article
Pathology
Daniella Serafin Couto Vieira, Sandro Wopereis, Laura Otto Walter, Lisandra de Oliveira Silva, Amanda Abdalla Biasi Ribeiro, Renato Salerno Wilkens, Braulio Leal Fernandes, Manoela Lira Reis, Lisleia Golfetto, Maria Claudia Santos-Silva
Summary: Ki-67 antigen has been proven to be a prognostic marker in various neoplasms, including breast cancer (BC). This study compared Ki-67 expression in BC samples using flow cytometry (FC) with immunohistochemical (IHC) examination, finding that FC provides results equivalent to IHC analysis and may allow for simultaneous analysis of more cells.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Polymer Science
Anette Lofstrand, Alexei Vorobiev, Muhammad Mumtaz, Redouane Borsali, Ivan Maximov
Summary: Vapor phase infiltration into a self-assembled block copolymer can enhance the etch selectivity for pattern transfer. By optimizing the process parameters, it was found that a high concentration of alumina infiltration can be achieved by reducing the exposure time and using appropriate precursor pulse durations. These results are significant for further understanding of the mechanisms involved in sequential infiltration synthesis and for optimizing carbohydrate-based etch masks for sub-10 nm pattern transfer.
Article
Engineering, Environmental
Jean-Sebastien Benas, Fang-Cheng Liang, Wei-Chen Chen, Chung-Wei Hung, Jung-Yao Chen, Ye Zhou, Su-Ting Han, Redouane Borsali, Chi-Ching Kuo
Summary: This review discusses the encapsulation of perovskite materials with block copolymers (BCPs) and highlights the use of Lewis acid base interaction to improve the stability of perovskite materials.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Marilia Cestari, Barbara Sthefani Caldas, Dyenefer Pereira Fonseca, Rodolfo Bento Balbinot, Danielle Lazarin-Bidoia, Issei Otsuka, Celso Vataru Nakamura, Redouane Borsali, Edvani Curti Muniz
Summary: Nanofibers containing silk fibroin, chondroitin sulfate, and silver sulfadiazine were prepared using electrospinning technique. The addition of poly (ethylene oxide) improved the electrospinnability. The nanofibers had a diameter between 262 and 328 nm before PEO removal and between 242 and 345 nm after PEO removal. CS and SSD remained in the nanofibers, and CS significantly influenced the remaining SSD content. The nanofibers were non-toxic to Vero cells and had antibacterial activity depending on the concentration of CS.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Hamed Ahmadi-Nohadani, Steve Nono-Tagne, Christopher J. Barrett, Issei Otsuka
Summary: A smart photo-actuator based on natural polysaccharides has been developed using electrospinning techniques. By controlling the solvent composition and polymer concentration, continuous nanofibers and nonwoven fabrics with responsive properties to UV and visible light are obtained.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Bassam Felipe Mogharbel, Marco Andre Cardoso, Ana Carolina Irioda, Priscila Elias Ferreira Stricker, Robson Camilotti Slompo, Julia Maurer Appel, Nathalia Barth de Oliveira, Maiara Carolina Perussolo, Claudia Sayuri Sacaki, Nadia Nascimento da Rosa, Dilcele Silva Moreira Dziedzic, Christophe Travelet, Sami Halila, Redouane Borsali, Katherine Athayde Teixeira de Carvalho
Summary: This study describes the development of nanoparticles capable of delivering L-DOPA and curcumin across the blood-brain barrier. The nanoparticles exhibited good biocompatibility and blood compatibility, making them potential formulations for brain delivery of these drugs.
Article
Chemistry, Multidisciplinary
Taiki Nishimura, Satoshi Katsuhara, Chaehun Lee, Brian J. Ree, Redouane Borsali, Takuya Yamamoto, Kenji Tajima, Toshifumi Satoh, Takuya Isono
Summary: This study introduces a novel block copolymer system by utilizing carbohydrates and inorganic hybrids, synthesized through click reactions. The block copolymers demonstrated various microphase-separated structures in both bulk and thin film states, with potential for nanopatterning applications after reactive ion etching.
Article
Pharmacology & Pharmacy
Carla Elise Heinz Rieg, Daiane Cattani, Nathalia Ferrazzo Naspolini, Vitoria Hayduck Cenci, Vera Lucia de Liz Oliveira Cavalli, Amanda Virtuoso Jacques, Marcus Vinicius Pereira Dos Santos Nascimento, Eduardo Monguilhott Dalmarco, Ana Carolina Rabello De Moraes, Maria Claudia Santos-Silva, Fatima Regina Mena Barreto Silva, Eduardo Benedetti Parisotto, Ariane Zamoner
Summary: The present study investigated the effects of perinatal exposure to glyphosate-based herbicide (GBH) in offspring's liver. The results showed that perinatal exposure to GBH increased Ca2+ influx, oxidative damage and inflammation in the liver of offspring. Additionally, the study found that GBH exposure led to increased levels of iron in the liver, blood and bone marrow, which might contribute to iron-driven hepatotoxicity. These findings indicate the potential harmful effects of GBH on liver function in offspring.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kevin Renault, Yoan Capello, Shun Yao, Sami Halila, Anthony Romieu
Summary: Latent cyclic carbon-centered nucleophiles, known as latent C-nucleophiles, have proven to be valuable in the field of reaction-based fluorescent probes. They are used to introduce a Michael acceptor moiety for analyte detection or to promote fluorogenic cascade reactions. C-nucleophiles with additional reactive handles offer opportunities for tuning properties and using ad hoc chemical moiety for drug-releasing capabilities. By exploring functionalized derivatives of barbituric acid, piperidine-2,4-dione, and Meldrum's acid, a versatile candidate suitable for structural optimization was identified. This study opens up possibilities for multifunctional fluorescence imaging probes and optically modulated theranostics.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Oncology
Giovanna Steffenello-Durigon, Alisson Bigolin, Ana Carolina Rabello de Moraes, Renata Cristina Rudolf-Oliveira, Joanita Angela Gonzaga Del Moral, Maria Claudia Santos-Silva
Summary: Acute promyelocytic leukemia, a subtype of acute myeloid leukemia, has shifted from a highly mortal to a curable disease with targeted therapy, but still carries a high risk of death, especially early death. A better understanding of the clinical and biological factors involving APL is crucial for identifying and treating cases accurately.
HEMATOLOGY TRANSFUSION AND CELL THERAPY
(2021)
