期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 3, 页码 332-347出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200354
关键词
biodegradable; hydrogels; neural cell culturing; poly(amidoamine); polymer applications
资金
- Fondazione Cariplo [2010-0501]
This paper reports on the synthesis and physico-chemical, mechanical, and biological characterization of two sets of poly(amidoamine) (PAA) hydrogels with potential as scaffolds for in vivo peripheral nerve regeneration. They are obtained by polyaddition of piperazine with N,N-methylenebis(acrylamide) or 1,4-bis(acryloyl)piperazine with 1,2-diaminoethane as cross-linking agent and exhibit a combination of relevant properties, such as mechanical strength, biocompatibility, biodegradability, ability to induce adhesion and proliferation of Schwann cells (SCs) preserving their viability. Moreover, the most promising hydrogels, that is those deriving from 1,4-bis(acryloyl)piperazine, allow the in vitro growth of the sensitive neurons of the dorsal root ganglia, thus getting around a critical point in the design of conduits for nerve regeneration.
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