期刊
MACROMOLECULAR BIOSCIENCE
卷 12, 期 11, 页码 1575-1582出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200274
关键词
click chemistry; glycoconjugates; micelles; polymer-peptide bioconjugate; reversible addition-fragmentation chain transfer (RAFT)
资金
- National Natural Science Foundation of China [20874050]
- Science and Technology Committee of Tianjin [09JCYBJC03200]
Comb-shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate-functional block glycocopolymers via thiol-ene click chemistry. In aqueous solution, the glycopolymer/GSH bioconjugate self-assembles to sugar-installed spherical micelles. The size of micelles decreases with increasing pH, demonstrating pH-responsive character. The isoelectric point (IEP) of the PMAGlc/GSH bioconjugate is estimated to be 3.43. The micelles show a specific interaction with the protein Concanavalin A. At endosomal pH, the PMAGlc/GSH bioconjugate can gradually degrade. These pH-responsive glycopolymer/peptide micelles with biological recognition and degradation can be used as multifunctional nanocarriers for targeted drug delivery.
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