Review
Pharmacology & Pharmacy
Francesca Milano, Annalia Masi, Marta Madaghiele, Alessandro Sannino, Luca Salvatore, Nunzia Gallo
Summary: Gelatin, a versatile natural polymer, is extensively used in healthcare due to its biocompatibility, biodegradability, low-cost, and chemical group availability. In the field of biomedicine, gelatin is utilized as a biomaterial for the development of drug delivery systems (DDSs) using various synthesis techniques. This review focuses on the techniques commonly used for gelatin-based micro- or nano-sized DDSs, highlighting the potential of gelatin as a carrier for bioactive compounds and its ability to control drug release kinetics. The various techniques, such as desolvation, nanoprecipitation, coacervation, emulsion, electrospray, and spray drying, are discussed along with their effects on DDSs' properties. Additionally, preclinical and clinical studies involving gelatin-based DDSs are thoroughly examined.
Article
Pharmacology & Pharmacy
Carmen Moya-Lopez, Alberto Juan, Murillo Donizeti, Jesus Valcarcel, Jose A. Vazquez, Eduardo Solano, David Chapron, Patrice Bourson, Ivan Bravo, Carlos Alonso-Moreno, Pilar Clemente-Casares, Carlos Gracia-Fernandez, Alessandro Longo, Georges Salloum-Abou-Jaoude, Alberto Ocana, Manuel M. Pineiro, Carolina Hermida-Merino, Daniel Hermida-Merino
Summary: A series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles with different nanostructures were designed for personalized treatment approaches. The systems were customized for drug release, ease of storage and local administration, biocompatibility, and cell growth capability at the biomolecular level. The study successfully formulated nanoparticles with different antitumoral compounds and characterized the bionanocomposites using various techniques. The drug release profiles were analyzed and correlated to the nanostructure of the drug delivery system.
Review
Pharmacology & Pharmacy
Lanlan Fan, Zheng Wang, Dunyun Shi
Summary: Melanoma, a highly lethal form of skin cancer, can be treated with targeted nanoparticle drug delivery systems. Nanoparticles functionalized with different ligands are used to deliver drugs specifically to melanoma cells, reducing systemic toxicity. Coating nanoparticles with melanoma or immune cell membranes further enhances drug accumulation at the tumor site and improves therapeutic effects. This review highlights recent advances in targeted nanoparticle drug delivery systems for melanoma therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Alaa Mansour, Maya Romani, Anirudh Balakrishna Acharya, Betul Rahman, Elise Verron, Zahi Badran
Summary: Modern drug discovery methods have led to the development of new drugs with significant potential, but properties like solubility and administration challenges may hinder their benefits. Biotechnology advances have also resulted in the development of molecules with short half-lives, requiring frequent administration. Controlled release systems are necessary to enhance treatment efficacy and improve patient compliance. This review provides an overview of different approaches used for drug delivery.
Review
Chemistry, Inorganic & Nuclear
Chunyan Jia, Glen B. Deacon, Yingjie Zhang, Chuanzhu Gao
Summary: This article summarizes the main problems of platinum-based anticancer drugs, introduces Pt-IV drugs and their characteristics, and focuses on the combination therapy with nanocarriers, looking forward to the application prospects of Pt-IV drugs and nanotechnology in the field of cancer chemotherapy.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Nanoscience & Nanotechnology
Jing Yang, Jinlu Shang, Liuxuan Yang, Daiqing Wei, Xia Wang, Qinmin Deng, Zhirong Zhong, Yun Ye, Meiling Zhou
Summary: Honokiol (HNK) is a small-molecule polyphenol with diverse pharmacological properties. However, its clinical application is limited by challenges such as low solubility, poor bioavailability, and rapid metabolism. To overcome these limitations, researchers have developed various nano-formulations for HNK delivery, offering advantages such as enhanced solubility, improved bioavailability, extended circulation time, and targeted drug delivery. This paper comprehensively reviews different types of nanomaterials used for HNK delivery over the past 15 years and discusses their latest applications, development prospects, and future challenges.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biophysics
Kaichun Li, Dong Zhou, Hengqing Cui, Guoyan Mo, Yu Liu, Kaikai Zheng, Zheng Zhou, Jian Li, Ping Dai, Jing Sun, Yuhong Zhang, Jie Gao
Summary: This study developed nanoparticles for cancer treatment that can gradually release drugs in the tumor environment, achieving deep tumor penetration and efficient tumor cell therapy. The nanoparticles have good stability and biocompatibility, making them a promising and practical approach for anticancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Paper & Wood
Hassan M. Ibrahim, Ghada M. Taha, Ekhlas A. El-Alfy, Manal K. El-Bisi
Summary: This paper describes the use of gelatin nanoparticles for drug delivery, specifically in enhancing the treatment of bacterial and fungal infections with weakly cell-penetrating antibiotics. By loading the antibiotics into gelatin nanoparticles and incorporating them into cotton gauze, higher antimicrobial activity is achieved.
Article
Chemistry, Physical
Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gaston Soria, N. Mariano Correa, Aldo Leal-Egana, Aldo R. Boccaccini
Summary: This study developed a system for delivering water-insoluble drugs, which can efficiently load drugs and increase the likelihood of drug uptake by cancer cells instead of healthy cells. The system also demonstrates high efficiency and stability during topical application, and it is less invasive compared to alternative methods.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Chiara Tramontano, Bruno Miranda, Giovanna Chianese, Luca De Stefano, Carlo Forestiere, Marinella Pirozzi, Ilaria Rea
Summary: This study combined inorganic diatomite nanoparticles with gelatin-stabilized gold nanoparticles to develop an optical platform for drug delivery. By increasing the thickness of the gelatin shells, the drug loading capacity was improved. Optical modeling was used to monitor drug release processes and proved to be an efficient tool for designing polymer-coated nanocarriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Yukun Chen, Zhenzhi Wang, Xiaofan Wang, Mingliang Su, Fan Xu, Lian Yang, Lijun Jia, Zhanxia Zhang
Summary: Nano drug delivery systems have been developed to improve the stability and water solubility of HCPT, thus enhancing its anticancer effect. Current research on HCPT nanomedicines has made progress, but there are still limitations.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Polymer Science
Osama A. Madkhali
Summary: In recent years, there has been increasing interest in using gelatin nanoparticles (GNPs) for treating infectious diseases. These nanoparticles have attractive properties for drug delivery due to their biocompatibility, biodegradability, and controlled drug release capacity. However, challenges such as controlling drug release rates, ensuring stability, scaling up production, mitigating immunogenic reactions, and optimizing drug loading efficiency need to be addressed. Nonetheless, GNPs hold great potential in infectious disease treatment, requiring ongoing research and innovation to overcome obstacles.
Article
Nanoscience & Nanotechnology
Wei Ha, Jun-Li Yang, Yan-Ping Shi
Summary: In recent years, there has been increasing attention on antibacterial nanosystems for cancer treatment involving bacterial infection. Silver nanoparticles (AgNPs) are widely used for their long-lasting and broad-spectrum antibacterial activity, but their inert surfaces make it difficult to load and deliver anticancer agents directly. This study developed biocompatible silver nanoparticles (TA-AgNPs) using tannic acid as a reducing and stabilizing agent. The TA-AgNPs exhibited low cytotoxicity and significant antibacterial activity. They could also effectively load and deliver the anticancer drug epirubicin hydrochloride (EPI), and showed pH- and GSH-sensitive drug release performance. The TA-AgNPs/EPI nanodrug demonstrated equal cytotoxicity to free EPI against cancer cells and prevented the influence of bacteria on EPI cytotoxicity.
ACS APPLIED NANO MATERIALS
(2023)
Review
Polymer Science
Azeez Yusuf, Awatif Rashed Z. Almotairy, Hanan Henidi, Ohoud Y. Alshehri, Mohammed S. Aldughaim
Summary: Nanotechnology has experienced rapid development in the past four decades and has revolutionized various aspects of everyday life. It has had significant impacts on fields like medicine and food industry, leading to improvements in shelf life of food, drug delivery, and development of specific therapeutics.
Article
Chemistry, Physical
T. Sagir, M. Huysal, M. Senel, S. Isik, N. Burgucu, O. Tabakoglu, M. Zaim
Summary: Novel folate-receptor-targeted polyamidoamine (PAMAM) dendrimer functional mesoporous silica-coated magnetic nanoparticles were prepared for drug delivery in photodynamic therapy. The nanoparticles showed efficient photodynamic therapy effect on MCF-7 cells, causing apoptosis.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Materials Science, Biomaterials
Jialiang Zhang, Ling'e Zhang, Shun Li, Changfeng Yin, Cheng Li, Wei Wu, Xiqun Jiang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Jialiang Zhang, Ling'e Zhang, Shun Li, Changfeng Yin, Cheng Li, Wei Wu, Xiqun Jiang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Review
Biochemistry & Molecular Biology
Weizhi Chen, Sensen Zhou, Lei Ge, Wei Wu, Xiqun Jiang
Article
Chemistry, Physical
Lei Jiang, Yang Ding, Xialin Xue, Sensen Zhou, Cheng Li, Xiaoke Zhang, Xiqun Jiang
Article
Materials Science, Biomaterials
Lei Jiang, Weizhi Chen, Sensen Zhou, Cheng Li, Xiaoke Zhang, Wei Wu, Xiqun Jiang
BIOMATERIALS SCIENCE
(2018)
Review
Materials Science, Multidisciplinary
Lei Jiang, Sensen Zhou, Xiaoke Zhang, Wei Wu, Xiqun Jiang
SCIENCE CHINA-MATERIALS
(2018)
Article
Nanoscience & Nanotechnology
Rutian Li, Jing Yan, Li Xie, Yu Zhang, Jiahui Gao, Qin Liu, Zitong Lin, Ping Jiang, Hanqing Qian, Mi Yang, Fenglei Wu, Xiqun Jiang, Baorui Liu, Lifeng Wang
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Mengen Zhang, Jingyi Zhu, Yun Zheng, Rui Guo, Shige Wang, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Shi
Review
Chemistry, Multidisciplinary
Huabing Chen, Zhanjun Gu, Hongwei An, Chunying Chen, Jie Chen, Ran Cui, Siqin Chen, Weihai Chen, Xuesi Chen, Xiaoyuan Chen, Zhuo Chen, Baoquan Ding, Qian Dong, Qin Fan, Ting Fu, Dayong Hou, Qiao Jiang, Hengte Ke, Xiqun Jiang, Gang Liu, Suping Li, Tianyu Li, Zhuang Liu, Guangjun Nie, Muhammad Ovais, Daiwen Pang, Nasha Qiu, Youqing Shen, Huayu Tian, Chao Wang, Hao Wang, Ziqi Wang, Huaping Xu, Jiang-Fei Xu, Xiangliang Yang, Shuang Zhu, Xianchuang Zheng, Xianzheng Zhang, Yanbing Zhao, Weihong Tan, Xi Zhang, Yuliang Zhao
SCIENCE CHINA-CHEMISTRY
(2018)
Article
Biochemical Research Methods
Yilun Wu, Kai Li, Lingdan Kong, Yueqin Tang, Gaoming Li, Wenbin Jiang, Mingwu Shen, Rui Guo, Qinghua Zhao, Xiangyang Shi
BIOCONJUGATE CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Renna Liu, Fanli Xu, Lu Wang, Mengxue Liu, Xueyan Cao, Xiangyang Shi, Rui Guo
Summary: Theranostic nanoplatforms combining photosensitizers and anticancer drugs, synthesized in this study using polydopamine-coated laponite nanoparticles loaded with indocyanine green and doxorubicin, showed high photothermal conversion efficiency and excellent photoacoustic imaging capability. The nanoplatforms released doxorubicin in a pH-sensitive and near-infrared laser-triggered manner, and could specifically target cancer cells overexpressing alpha(v)beta(3) integrin, demonstrating promising potential for PA imaging-guided chemo-phototherapy.
Article
Pharmacology & Pharmacy
Yucheng Peng, Xiaomeng Wang, Yue Wang, Yue Gao, Rui Guo, Xiangyang Shi, Xueyan Cao
Summary: The design of multimodal imaging nanoplatforms with improved tumor accumulation is a major trend in precision nanomedicine. In this study, macrophage-laden gold nanoflowers embedded with ultrasmall iron oxide nanoparticles were developed for enhanced dual-mode CT and MR imaging of tumors.
Article
Chemistry, Analytical
Huan Chen, Yiming Zhang, Lulu Li, Rui Guo, Xiangyang Shi, Xueyan Cao
Summary: Cell-based immunotherapy, particularly T cell-mediated immunotherapy triggered by Au DENPs-MPC loaded with CpG-ODN, shows promising potential in completely eliminating cancer by enhancing the antigen presentation ability of BMDCs and activating T cells to inhibit tumor cell growth.
Article
Chemistry, Multidisciplinary
Xinxin Hao, Bei Xu, Huan Chen, Xiaomeng Wang, Jiulong Zhang, Rui Guo, Xiangyang Shi, Xueyan Cao
Review
Chemistry, Multidisciplinary
Hanqing Qian, Baorui Liu, Xiqun Jiang
MATERIALS TODAY CHEMISTRY
(2018)
