期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 10, 页码 1426-1431出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100230
关键词
biomaterials; cell encapsulation; collagen peptide; hydrogels; star PEG polymers
资金
- NSF [0848325-CHE]
Collagen peptide-based hydrogels are prepared and characterized for application in 3D cell growth. Physical hydrogels are formed by covalently linking a collagen-based peptide to an 8-arm poly(ethylene glycol) star polymer. The resulting viscoelastic hydrogels have the ability to melt into a liquid-like state near the melting temperature of the collagen triple helix and reform back into an elastic-state at room temperature, adding a thermoresponsive feature to the material. In addition, the hydrogels possess desirable stiffness, as well as a highly cross-linked network of pores where cells are found to reside, making the hydrogels promising scaffolds for the culture of hMSCs.
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