期刊
MACROMOLECULAR BIOSCIENCE
卷 12, 期 1, 页码 93-103出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100277
关键词
dendrimers; drug delivery systems; kidney; platinum linkers; sunitinib
资金
- European Framework program FP6 [LSHB-CT-2007-036644]
The development of a macromolecular conjugate of a multitargeted tyrosine kinase inhibitor is described that can be used for renal-specific delivery into proximal tubular cells. A novel sunitinib analogue, that is, 17864, is conjugated to a NH2-PAMAM-G3 dendrimer via the platinum (II)-based Universal Linkage System (ULS (TM)). The activity of 17864 is retained after coordination to the ULS linker alone or when coupled to NH2-PAMAM-G3. 17864-UlS-NH2-PAMAM-G3 is non-toxic to proximal tubular cells in vitro. After intravenous administration to mice, 17864-UlS-NH2-PAMAM-G3 rapidly and efficiently accumulates in the kidneys. These results are encouraging for future studies focusing on the development of novel therapeutics for the treatment of renal diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据