Review
Engineering, Biomedical
Hanmei Li, Yao Wang, Qi Tang, Dan Yin, Chuane Tang, En He, Liang Zou, Qiang Peng
Summary: The formation of a protein corona (PC) on nanoparticles (NPs) in the blood can influence their behavior. Strategies to reduce PC formation or exploit it to enhance NP functions are discussed in this review. Studying protein-NP interactions can provide insights into their clinical activity in health and disease.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Xiaoxuan Yu, Zihui Weng, Ziyang Zhao, Jiayun Xu, Zhenhui Qi, Junqiu Liu
Summary: Protein nanomaterials, with their better biocompatibility and ability to self-assemble into highly ordered cage-like structures, are widely used as target delivery vehicles for therapeutic goods in targeted drug delivery.
Article
Polymer Science
Wanda Celentano, Stefania Ordanini, Riccardo Bruni, Luca Marocco, Pietro Medaglia, Andrea Rossi, Stefano Buzzaccaro, Francesco Cellesi
Summary: Well-defined amphiphilic PCL-PEG copolymers with complex molecular architectures were synthesized using ROP and ATRP. These copolymers were used to produce self-assembled nanoparticles for drug encapsulation, with the ability to tune self-assembly, particle size, and drug loading by designing specific macromolecular architectures.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Xiaoxia Wu, Jie Xing, Yonglei Lyu, Jingjing Yu, Jinghui Yang, Dawei Qi, Xin Wang, Jie Lin, Guoliang Shao, Aiguo Wu, Jianwei Li
Summary: Multicomponent self-assembly offers a strategy to explore ordered, complex, and dynamic nanosystems and to harness the property of the whole system. By using a thiol-disulfide exchange reaction, control over co-self-assembly can be achieved, resulting in a stable nanosystem with high drug-loading efficiency.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Roxanna S. Ramnarine-Sanchez, Janos M. Kanczler, Nicholas D. Evans, Richard O. C. Oreffo, Jonathan I. Dawson
Summary: This paper reports a new reaction-diffusion self-assembly system, in which proteins function as diffusive reactants to assemble stable clay-protein composite hydrogels. Using this method, scalable and highly stable 3D protein patterns can be generated at sub-cellular resolution, and can guide cell behavior to achieve precise bone tissue template formation.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Ying-Ying Guan, Shao-Qi Zeng, Yin Qin, Yan Mu, Hong Liu
Summary: The development of a TPGS-decorated drug delivery system showed enhanced intracellular drug accumulation, induction of apoptosis in drug resistant tumor cells, and significant inhibitory effects on tumor development and metastasis.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Runkai Lv, Zhengzheng Qian, Xiaopeng Zhao, Fei Xiong, Yingjie Xu, Wenpei Fan, Xikuang Yao, Wei Huang
Summary: Polymer-induced self-assembly is a powerful strategy for fabricating stimuli-responsive drug delivery nanosystems. In this study, a series of block copolymers were designed and synthesized, and their self-assembly behavior with gold nanoparticles was investigated. The preparation of a near-infrared light-responsive gold nanovesicle was optimized, which efficiently encapsulated an anticancer drug and prevented premature leakage. Upon laser irradiation, the loaded drug was rapidly released, leading to superior antitumor efficacy in a tumor model.
Article
Medicine, Research & Experimental
Shouhui Yi, Rongqiang Liao, Wei Zhao, Yusheng Huang, Yi He
Summary: Combination therapy offers advantages for cancer treatment, but different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo, leading to uncontrollable concentration ratio of therapeutic agents. Multifunctional co-delivery systems can provide targeted delivery and controlled release in response to tumor microenvironment, resulting in better synergistic anticancer effect and potential clinical applications.
Article
Chemistry, Physical
V. S. S. L. Prasad Talluri, Botagoz Mutaliyeva, Altynay Sharipova, Vamseekrishna Ulaganathan, Sri Santhi Lanka, Saule Aidarova, Aliya Suigenbayeva, Aiym Tleuova
Summary: L-asparaginase is an important enzyme used in therapeutic applications, and immobilization can minimize its side effects and improve its performance.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Biomaterials
Zhijia Lv, Yue Cao, Dongzhi Xue, Hao Zhang, Shijie Zhou, Na Yin, Wanying Li, Longhai Jin, Yinghui Wang, Hongjie Zhang
Summary: A multifunctional nanodrug (UMD) consisting of up-conversion nanoparticles (UCNPs) core, NH2-MIL-53 (Fe) shell as a photosensitizer, and a carrier for doxorubicin hydrochloride (Dox) chemotherapy was developed for treating gliomas. Lactoferrin (LF) modification on UMD surface allowed it to penetrate the blood-brain barrier and target cells. The UMD exhibited NIR-mediated photodynamic therapy (PDT), chemodynamic therapy (CDT) through redox reactions, and targeted chemotherapy for effective suppression of orthotopic gliomas.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Weicai Wang, Yuanyuan Wang, Minghui Ma, Hyung Jong Jin, Xuemei Li
Summary: A cancer-targeted cascade bioreactor was constructed by inserting glucose oxidase, catalase, and chlorin e6 into human serum albumin assembly molecules, which promoted oxygen production and cytotoxic singlet oxygen generation in cancer cells, enhancing the efficacy of photodynamic therapy and chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Corey. A. Stevens, Kuljeet Kaur, Harm-Anton Klok
Summary: Protein-polymer conjugates combine the stability of polymers with the diversity, specificity, and functionality of biomolecules, resulting in hybrid materials with unique properties for drug delivery applications. Engineering amphiphilicity into these bioconjugate materials can lead to phase separation and assembly of high-order structures, with multiple levels of organization and emergence of new properties at each level influenced by lower levels.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Cheng Gao, Qingfu Wang, Junyan Li, Cheryl H. T. Kwong, Jianwen Wei, Beibei Xie, Siyu Lu, Simon M. Y. Lee, Ruibing Wang
Summary: This study reports an in vivo strategy to construct cell-based nanomedicine carriers using bacteria-mimetic gold nanoparticles, which are selectively phagocytosed by immune cells and self-assemble into intracellular aggregates. The optimized carriers improve drug delivery and enhance antitumor immunotherapy through photothermal treatment and immune checkpoint blockade.
Article
Chemistry, Multidisciplinary
Lan Yang, Xiao He, Zhiying Zeng, Jiakun Tang, Dongmei Qi, Huijie Ma, Hui Chen, Xinghai Ning, Xuli Feng
Summary: This study presents a nucleus-targeted synergistic chemo-photodynamic therapy using the self-assembly of chlorin e6 (Ce6) and doxorubicin (DOX), which demonstrates enhanced cellular uptake and accumulation in the nucleus, leading to improved therapeutic efficacy for cancer treatment. The introduction of clickable dibenzocyclooctyne (DIBO) functionalized lysine (D-K) and crosslinkers enables efficient self-assembly of the nanodrugs, showing great potential for nucleus-specific drug delivery strategies.
Review
Pharmacology & Pharmacy
Alaa Mansour, Maya Romani, Anirudh Balakrishna Acharya, Betul Rahman, Elise Verron, Zahi Badran
Summary: Modern drug discovery methods have led to the development of new drugs with significant potential, but properties like solubility and administration challenges may hinder their benefits. Biotechnology advances have also resulted in the development of molecules with short half-lives, requiring frequent administration. Controlled release systems are necessary to enhance treatment efficacy and improve patient compliance. This review provides an overview of different approaches used for drug delivery.
Article
Engineering, Biomedical
Chengnan Li, Zongshao Li, Yinxiang Zeng, Xianshuo Cao, Huimin Zhao, Yi Yan Yang, Peiyan Yuan, Xihong Lu, Xin Ding
Summary: The Co3O4 nanowire electrode shows significant antibacterial effect against both Gram-positive and Gram-negative bacteria, while being rechargeable, antibiotic-free, and wearable. This nanostructured capacitive electrode provides a promising approach to treat bacterial skin infection.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Jiayu Leong, Danrong Shi, Jeremy Pang Kern Tan, Chuan Yang, Shengcai Yang, Yanming Wang, Yeen Shian Ngow, Jessica Kng, Nithiyaa Balakrishnan, Shu Qin Peng, Chun Siang Yeow, Balamurugan Periaswamy, Shrinivas Venkataraman, Andrea Lay-Hoon Kwa, Xiaoli Liu, Hangping Yao, Yi Yan Yang
Summary: A series of membrane-disrupting polyionenes have been synthesized, which are effective against bacteria and fungi, and have fast acting properties against clinically isolated drug resistant strains. These polyionenes are also effective in preventing infections caused by nonenveloped and enveloped viruses.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Guangshun Yi, Shujun Gao, Hongfang Lu, Wei Zhi Khoo, Shaoqiong Liu, Shuyun Chng, Yi Yan Yang, Jackie Y. Ying, Yugen Zhang
Summary: Vertically aligned layered double hydroxide (V-LDH) arrays with good topology have been grown on various substrates using a hydrolysis method. The V-LDH surface has enhanced antibacterial properties and biocompatibility, making it potentially useful in a wide range of applications.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Chengnan Li, Zongshao Li, Yingying Gan, Fenglin Jiang, Huimin Zhao, Jeremy Tan, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: Polydopamine-coated porous magnetic nanoparticles were fabricated for effective separation and photothermal killing of MRSA, with excellent bacteria-affinitive property for rapid and efficient MRSA capture. These nanoparticles displayed selective capture of Gram-positive bacteria, attributed to their binding capability to peptidoglycan, offering potential applications in water disinfection, blood purification, and bacterial infection treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Aerospace
Lei Shi, Yiyan Yang, Xue Yang, Rui Ran, Fei Qin, Guoqiang He
Summary: This study investigates the reinforcement mechanism of an embedded rocket on the back pressure resistance of the RBCC inlet through experimental and numerical methods. It identifies three typical rocket operation stages and observes two different patterns of flow separation caused by the synergy of the rocket jet and back pressure. Appropriate embedded rocket operation effectively enhances the back pressure resistance of the RBCC inlet and improves compression efficiency and expansion ratio.
AEROSPACE SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Qiaohua Qiu, Chuan Yang, Yanming Wang, Cherylette Anne Alexander, Guangshun Yi, Yugen Zhang, Xiaohong Qin, Yi Yan Yang
Summary: This study reports on silane-functionalized polyionenes-coated cotton textiles with durable potent antimicrobial and antiviral activities. The polymers demonstrated broad-spectrum antimicrobial activity against various types of pathogenic microbes and remained effective even after multiple washings.
Article
Infectious Diseases
Yingxiao Yu, Huimin Zhao, Jiayin Lin, Zongshao Li, Guobao Tian, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: The combination of non-antibiotic drugs auranofin and pentamidine exhibits a strong synergistic antibacterial effect against multidrug-resistant Gram-negative bacteria. The mechanism involves bacterial membrane disruption and enhanced intracellular drug uptake, resulting in efficient bacterial killing and delayed drug resistance development.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Engineering, Aerospace
Lei Shi, Yiyan Yang, Xue Yang, Guojun Zhao, Fuhao Chen, Guoqiang He
Summary: This study investigates the real start limits and operational characteristics of a central strut-based rocket-based combined-cycle (RBCC) inlet through theoretical analysis and numerical simulations. It establishes a two-dimensional analysis model and validates the theoretical calculation methods. The study examines the impact of the rocket on the inlet start process and analyzes the influence of key parameters on the start limits. Finally, a positive control method based on the rocket operation is proposed to enhance the start performance and compression efficiency of the inlet in subsequent operations.
JOURNAL OF AEROSPACE ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Shengcai Yang, Jiayu Leong, Yanming Wang, Rachel Sim, Ko Hui Tan, Yau Hong Chua, Nathanael Tan, Ashlynn L. Z. Lee, Joyce Tay, Yi Yan Yang
Summary: By neutralizing the positive charges of cationic anticancer polymers/peptides and self-assembling into nanoparticles, we have successfully developed a nanoparticulate delivery system with improved stability and reduced toxicity. The system exhibits excellent anticancer activity, can enter cancer cells, and bypass drug resistance mechanisms. In vivo experiments demonstrate that the system effectively inhibits tumor growth with minimal side effects.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Mengjing Fu, Yingying Gan, Fenglin Jiang, Xue Lv, Nathanael Tan, Xiaomiao Zhao, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: This study reports the development of an antibiotic-loaded interpenetrating polymer network hydrogel that achieves sustained release of antibiotics through chemical and physical crosslinking interactions. The hydrogel incorporates the antibiotic gentamicin via electrostatic interaction, resulting in pH-responsive drug release and increased mechanical strength. The hydrogel demonstrates long-lasting antibacterial activity against both Gram-positive and Gram-negative bacteria, and in vivo studies show that it effectively eliminates bacteria in wounds and accelerates wound healing compared to traditional dressings.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Microbiology
Yiyan Yang, Keith Dufault-Thompson, Rafaela Salgado Fontenele, Xiaofang Jiang
Summary: This study demonstrates the formation of viral-host chimeric RNAs in SARS-CoV-2-infected cells and identifies two genomic insertions derived from human rRNA regions. These findings provide direct evidence for the significance of host-derived insertions in viral evolution.
Article
Engineering, Aerospace
Lei Shi, Xue Yang, Yiyan Yang, Xiang Tang, Fei Qin, Guoqiang He
Summary: Stable operation of the RBCC engine in the scramjet mode is crucial for achieving wide airspace and high-speed flight envelope. The study explores the mechanism of how an embedded rocket enhances ignition and flame stabilization of secondary fuel. Experimental results show that the embedded rocket operating at a low mass flow rate and fuel-rich state can efficiently guide the flame source, enhance fuel-air mixing, and improve combustion.
AEROSPACE SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Huimin Zhao, Lan-lan Zhong, Chuan Yang, Ning Tang, Yanwei He, Wan He, Zihan Zhao, Changbu Wu, Peiyan Yuan, Yi Yan Yang, Guo-bao Tian, Xin Ding
Summary: A nanocomplex (CMS-pEt_20 NP) has been developed to reverse colistin resistance in multidrug-resistant Gram-negative bacterial infections.
Article
Engineering, Biomedical
Chengyuan Qin, Ning Tang, Yingying Gan, Huimin Zhao, Yuzhen Li, Guo-bao Tian, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: This study discovered that curcumin can reverse colistin-resistant bacteria and prepared negatively charged poly(ethylene glycol)-functionalized liposomes encapsulating both curcumin and colistin, which showed stronger antibacterial activity against colistin-resistant bacteria than the combination of free curcumin and colistin. Mechanistical studies revealed that the liposomes restored the affinity of colistin for the bacterial membrane and improved the uptake of curcumin, leading to reduced efflux pump activity and achieving a synergistic effect. In addition, the liposomes showed no toxicity at effective antibacterial doses and demonstrated therapeutic efficacy in an intestinal bacterial infection model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Ashlynn Ling Zhi Lee, Nithiyaa Balakrishnan, Jian Yao Ng, Shaoqiong Liu, Zhan Yuin Ong, Yanming Wang, Shujun Gao, Yi Yan Yang
Summary: This article reports a synthetic peptide/gelatin hybrid hydrogel that can support cell and tissue growth. The hybrid hydrogel supports tumor growth both in vitro and in vivo, making it a promising scaffold for cancer research. The results demonstrate the potential of this hydrogel as an alternative to animal-derived matrices.
ADVANCED HEALTHCARE MATERIALS
(2023)
