期刊
MACROMOLECULAR BIOSCIENCE
卷 9, 期 3, 页码 262-267出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800263
关键词
adhesion; cellulose; conjugated polymers; enzymes; hydrogels
资金
- Ministry of Education, Culture, Science, Sports and Technology of Japan
- JSPS
The effect of Ph-OH group content on gelation time, mechanical properties, hydrophobicity, and cellular adhesiveness of hydrogels produced from carboxymethylcellulose derivatives is investigated. A higher Ph-OH group content induces faster gelation and yields more brittle and hydrophobic gels. After 4 h of seeding, a larger number of L929 fibroblasts adhere to the hydrogel of the CMC-Ph that contains 15.4 Ph-OH groups per 100 repeat units of uronic acid (97% adhesion rate) than to the gel of CMC-Ph with only 8.4 Ph-OH groups (62% adhesion rate). The results demonstrate that controlling the Ph-OH group content is an effective and useful way to control cellular adhesion and proliferation on the hydrogels, as well as gelation time and mechanical properties of the gels.
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