期刊
MACROMOLECULAR BIOSCIENCE
卷 9, 期 6, 页码 575-584出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800293
关键词
biological application of polymers; emulsion polymerization; functionalization of polymers; nanoparticles; polyurethanes
资金
- Alexander von Humboldt Foundation
The functionalization of well-defined PU nanocapsules with an aqueous core prepared by performing a polyaddition at the interface of inverse (water-in-oil) miniemulsion droplets is demonstrated. The miniemulsion technique involving the nanoreactor concept allows one to obtain an encapsulation efficiency as high as 90% within the nanocapsules. A pH independent fluorescent dye is used as a model system for the aqueous core. By varying the molar ratio of the diol to the diisocyanate at a fixed surfactant concentration, the shell thickness of the nanocapsules can be finely tuned. The carboxy- and amino-functionalized surface of the nanocapsules can be tailored by an in-situ carboxymethylation reaction and by physical adsorption of a cationic polyelectrolyte, i.e. PAEMA or PEI. The increased uptake of amino-functionalized fluorescent nanocapsules by HeLa cells clearly demonstrates the potential of the functionalized nanocapsules to be successfully exploited as biocarriers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据