期刊
MACROMOLECULAR BIOSCIENCE
卷 8, 期 3, 页码 231-238出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200700157
关键词
drug delivery systems; galactose carrying copolymers; hepatocyte specific targeting; inclusion stability; self assembly
Core-forming hydrophobic alkyl groups were incorporated into amphiphilic PVLA to enhance the stability and inclusion ability of the homopolymeric micelles in water. The CAC and hepatocyte targeting in the synthesized P(VLA-co-VBH) were investigated in vitro. The CAC of the copolymers decreased and the stability of the copolymeric micelles increased with the incorporation of hydrophobic groups into the homopolymer. The galactose moieties in the copolymer could be recognized by the ASGP-R of the hepatocytes through a receptor-mediated mechanism. The copolymers efficiently delivered a water-insoluble drug to the hepatocytes. Hence, they be used to deliver hydrophobic drugs to cure various liver diseases.
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