期刊
MACROMOLECULAR BIOSCIENCE
卷 8, 期 4, 页码 339-346出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200700161
关键词
drug-delivery systems; micelles; non-linear polymers; particle size distribution; water-soluble polymers
Comb-like polymers with biocompatible oxyethylene backbones and amphiphilic side groups were synthesized via polymer-analogous reactions. Using these polymers, indomethacin-loaded polymeric micelles were fabricated with various drug-to-polymer weight ratios using the oil-in-water emulsion technique. In addition, the size, size distribution, CMC, drug-loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume-weighted diameters of polymeric micelles ranged from 10 to 140 nm and were narrowly distributed for passive targeting drug delivery. The CMCs were lower (approximate to 10(-8) m) than for conventional. surfactants and block copolymers.
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