Review
Immunology
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu
Summary: This review examines the role of purinergic signaling in ischemia-reperfusion injury and rejection after heart transplantation, as well as its clinical applications and prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Man Wu, Guang Lu, Yuan-zhi Lao, Hong Zhang, Dan Zheng, Zhao-qing Zheng, Juan Yi, Qian Xiang, Li-ming Wang, Hong-sheng Tan, Hua Zhou, Han-ming Shen, Hong-xi Xu
Summary: Mitophagy is a selective form of autophagy that removes damaged mitochondria via the autophagy-lysosome pathway. GeB, a natural compound, can promote the PINK1-Parkin-mediated mitophagy pathway, potentially protecting against I/R brain injury.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Immunology
Marwa M. M. Refaie, Randa Ahmed Ibrahim, Sayed Shehata
Summary: Torsion of the spermatic cord is a common and dangerous health issue that may lead to testicular necrosis and infertility. Cilostazol (CLZ) has shown significant reversal of the damaging effects of testicular ischemia/reperfusion (TIR) through its anti-inflammatory, antioxidant, and anti-apoptotic activities, as well as promotion of testicular vascularity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Aritra Bhadra, April K. Scruggs, Silas J. Leavesley, Naga Annamdevula, April H. George, Andrea L. Britain, Christopher M. Francis, Jennifer M. Knighten, Thomas C. Rich, Natalie N. Bauer
Summary: Second messenger signaling is essential for cellular processes. Our study demonstrates that cAMP-enriched EVs can induce second messenger signaling pathways, revealing the significance of EVs as a novel intercellular mechanism for cAMP signaling.
CELLULAR SIGNALLING
(2022)
Article
Cardiac & Cardiovascular Systems
Jie Su, Pierre Coleman, Angeliki Ntorla, Rhys Anderson, Michael J. Shattock, Joseph R. Burgoyne
Summary: This study demonstrates that the cytosolic DNA sensor cGAS can activate PKGI directly through the generation of cGAMP, showing a link between inflammation and blood pressure regulation.
Article
Biochemistry & Molecular Biology
Rachel Aruldas, Laura Buczek Orenstein, Sade Spencer
Summary: Repeated cocaine exposure induces changes in AMPK and pAMPK in different brain regions and cellular compartments, with some differences between acute withdrawal and ongoing cocaine treatment. Pretreatment with metformin, an indirect AMPK activator, enhances acute cocaine-induced locomotor activity but blocks the development of sensitization. These findings provide insights into the dynamics of AMPK activation in subcellular compartments and support the potential use of metformin for the treatment of cocaine use disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Yang Sun, Dengyue Xu, Weidong Yang, Hongquan Zhang, Yi Su, Bin Gao, Xiaowei Zou, Yiming Zhong, Huanwei Sun, Liangbi Xiang
Summary: Diallyl trisulfide (DATS) can reduce neuronal damage caused by oxidative stress by activating AMPK, stabilizing mitochondrial biogenesis and dynamic balance.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yun Xia, Feng He, Mohamed Bassirou Moukeila Yacouba, Huimin Zhou, Jingfan Li, Ying Xiong, Jingjing Zhang, Hui Li, Yanlin Wang, Jianjuan Ke
Summary: The activation of adenosine A2a receptor plays a crucial role in protecting myocardial cells from ischemia-reperfusion injury through regulating autophagy and apoptosis processes. This finding provides a potential target for preventing and treating myocardial ischemia-reperfusion injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Francesca Grisan, Martina Spacci, Carlotta Paoli, Andrea Costamagna, Marco Fantuz, Miriam Martini, Konstantinos Lefkimmiatis, Alessandro Carrer
Summary: This study demonstrates the impact of cholesterol on the plasticity of normal pancreatic acinar cells and the cyclic AMP/PKA axis. Cholesterol supplementation enhances ductal transdifferentiation in isolated primary wild-type acinar cells, associated with cAMP signaling. The ability of cholesterol to activate cAMP signaling is lost in tumor cells.
Review
Pharmacology & Pharmacy
Corrado De Marco, Thierry Charron, Guy Rousseau
Summary: Adenosine has the potential benefits in the treatment of acute myocardial infarction by inhibiting the pathophysiological processes leading to reperfusion injury. However, the heterogenous evidence regarding its effects has resulted in limited uptake in clinical practice. Therefore, studying the dose, route, timing, and site of administration of adenosine is crucial for its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rui Xie, Kunlong Yang, Elisabeth Tumukunde, Zhiqiang Guo, Bei Zhang, Yinghang Liu, Zhenhong Zhuang, Jun Yuan, Shihua Wang
Summary: This study identified six RGS proteins in Aspergillus flavus and revealed their important functions in regulating conidia, sclerotia, and aflatoxin formation. The results provide valuable information for controlling the contamination of A. flavus and mycotoxins produced by this fungus in agricultural crops.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Oncology
Yan Shi, Shu-Ai Hou
Summary: Metformin may reduce oxidative stress injury induced by MIRI by activating AMPK to inhibit the expression of NOX4, thereby reducing myocardial oxidative damage and apoptosis, and alleviating reperfusion injury.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Article
Cell Biology
Haoran Hu, Xuyu Cheng, Fei Li, Zhu Guan, Jian Xu, Dongming Wu, Yiyun Gao, Xinyu Zhan, Ping Wang, Haoming Zhou, Zhuqing Rao, Feng Cheng
Summary: Aging impairs efferocytosis of macrophages, leading to increased liver ischemia and reperfusion injury. Activation of MerTK can improve efferocytosis and reduce inflammation and liver injury. This study provides a new mechanism and potential therapy for promoting inflammation resolution and efferocytosis in aged livers.
CELL DEATH DISCOVERY
(2023)
Article
Pharmacology & Pharmacy
Xu Jing, Dandan Ren, Fei Gao, Ye Chen, Xiao Wu, Yue Han, Qingsheng Han, Liang Li, Xiaojie Wang, Wei Tang, Yan Zhang
Summary: Recent studies have shown that PDCD4 plays a critical role in modulating signal transduction pathways in acute kidney injury (AKI). Inhibition of PDCD4 or tyrosine kinase Fgr, and targeting the NOTCH1 pathway may have therapeutic potential for mitigating AKI.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Surgery
Shoichi Kageyama, Hirofumi Hirao, Kojiro Nakamura, Bibo Ke, Min Zhang, Takahiro Ito, Antony Aziz, Damla Oncel, Fady M. Kaldas, Ronald W. Busuttil, Rebecca A. Sosa, Elaine F. Reed, Jesus A. Araujo, Jerzy W. Kupiec-Weglinski
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Immunology
Yuting Jin, Changyong Li, Dongwei Xu, Jianjun Zhu, Song Wei, Andrew Zhong, Mingwei Sheng, Sergio Duarte, Ana J. Coito, Ronald W. Busuttil, Qiang Xia, Jerzy W. Kupiec-Weglinski, Bibo Ke
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Takehiro Fujii, Sergio Duarte, Eudora Lee, Bibo Ke, Ronald W. Busuttil, Ana J. Coito
LIVER TRANSPLANTATION
(2020)
Article
Biochemistry & Molecular Biology
Changyong Li, Mingwei Sheng, Yuanbang Lin, Dongwei Xu, Yizhu Tian, Yongqiang Zhan, Longfeng Jiang, Ana J. Coito, Ronald W. Busuttil, Douglas G. Farmer, Jerzy W. Kupiec-Weglinski, Bibo Ke
Summary: The study demonstrates that myeloid-specific Foxo1 knockout mice are resistant to oxidative stress-induced liver injury by enhancing beta-catenin-mediated Gli1/Snail signaling, reducing inflammation, and inhibiting necroptosis. The colocalization of Foxo1 and beta-catenin in macrophages leads to the activation of Gli1/Snail signaling and suppression of RIPK3 and NEK7/NLRP3 expression under inflammatory conditions. Disruption of this axis exacerbates liver damage, leading to increased necroptosis and inflammatory response.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Gastroenterology & Hepatology
Mingwei Sheng, Yuanbang Lin, Dongwei Xu, Yizhu Tian, Yongqiang Zhan, Changyong Li, Douglas G. Farmer, Jerzy W. Kupiec-Weglinski, Bibo Ke
Summary: The CD47-SIRP alpha signaling pathway plays a crucial role in MSC-mediated immune regulation during sterile inflammatory liver injury. Activation of this pathway controls NEK7/NLRP3 activity through a direct interaction between Gli1 and NICD, which modulates the inflammatory response in MSC-immunotherapy.
Review
Immunology
Dongwei Xu, Yizhu Tian, Qiang Xia, Bibo Ke
Summary: Liver diseases are a major global health burden, with the cGAS-STING pathway playing a crucial role in their development. Overactivation of cGAS-STING has been linked to liver disorders, suggesting that this pathway may be a promising therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tao Yang, Xiaoye Qu, Xiao Wang, Dongwei Xu, Mingwei Sheng, Yuanbang Lin, Michael Ke, Ci Song, Qiang Xia, Longfeng Jiang, Jun Li, Douglas G. Farmer, Bibo Ke
Summary: This study found that the macrophage STING-YAP axis controls the development of hepatic steatosis by reprogramming lipid metabolism. These findings provide new insights into the regulatory mechanism of macrophage STING-driven YAP activity in lipid control.
Article
Gastroenterology & Hepatology
Xiaoye Qu, Tao Yang, Xiao Wang, Dongwei Xu, Yeping Yu, Jun Li, Longfeng Jiang, Qiang Xia, Douglas G. Farmer, Bibo Ke
Summary: This study found that macrophage RIPK3 promotes NOD1-dependent inflammation and calcineurin/TRPM7-induced cell death cascade by triggering the XBP1-Foxo1 axis and its target gene Zc3h15, which is crucial for activating NOD1 and calcineurin/TRPM7 function. This has important implications for stress-induced liver inflammatory injury.
Article
Gastroenterology & Hepatology
Yongqiang Zhan, Dongwei Xu, Yizhu Tian, Xiaoye Qu, Mingwei Sheng, Yuanbang Lin, Michael Ke, Longfeng Jiang, Qiang Xia, Fady M. Kaldas, Douglas G. Farmer, Bibo Ke
Summary: Macrophage TXNIP deficiency enhances CYLD activity and activates the NRF2-OASL1 signaling, controlling oxidative/endoplasmic reticulum stress-induced liver injury. The NRF2-regulated target gene OASL1 plays a crucial role in modulating STING-mediated TBK1 activation and apoptotic/necroptotic cell death pathway.
Meeting Abstract
Surgery
Y. Tian, D. Xu, M. Sheng, Y. Zhan, Y. Lin, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Meeting Abstract
Surgery
D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Meeting Abstract
Surgery
D. Xu, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Meeting Abstract
Surgery
M. Sheng, Y. Lin, C. Li, Y. Tian, D. Xu, Y. Zhan, A. J. Coito, D. G. Farmer, R. W. Busuttil, J. W. Kupiec-Weglinski, B. Ke
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Changyong Li, Mingwei Sheng, Yizhu Tian, Yuanbang Lin, Dongwei Xu Song Wei, Yongqiang Zhan, Ronald Busuttil, Jerzy Kupiec-Weglinski, Bibo Ke
JOURNAL OF HEPATOLOGY
(2020)
Meeting Abstract
Surgery
S. Kageyama, H. Hirao, K. Kadono, K. Nakamura, K. J. Dery, T. Ito, D. Oncel, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec-Weglinski
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)