Review
Immunology
Martin Maronek, Irene Marafini, Roman Gardlik, Rene Link, Edoardo Troncone, Giovanni Monteleone
Summary: Inflammatory bowel diseases (IBD) refer to chronic inflammatory conditions of the gastrointestinal tract, including Crohn's disease (CD) and ulcerative colitis (UC). Excessive production of matrix metalloproteinases (MMPs) without sufficient inhibition by tissue inhibitors of metalloproteinases (TIMPs) in inflamed tissue of IBD patients contributes significantly to mucosal degradation in IBD-related pathologies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ines Silva, Joao Solas, Rui Pinto, Vanessa Mateus
Summary: This study successfully developed and validated a chronic TNBS-induced colitis mouse model. After week 4, clinical and inflammation signs remained stable, suggesting the model develops within 4 weeks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Agata Michalak, Beata Kasztelan-Szczerbinska, Halina Cichoz-Lach
Summary: Visceral adipose tissue is closely related to inflammatory bowel disease (IBD), with body fat impacting the pattern of pharmacological treatment. The classification of Crohn's disease and ulcerative colitis appears to be more diverse than previously thought. However, the translation of this knowledge into practical management of IBD patients is still uncertain.
Article
Multidisciplinary Sciences
Yuko Akazawa, Tomohito Morisaki, Hiroko Fukuda, Kiyuu Norimatsu, Junya Shiota, Keiichi Hashiguchi, Maiko Tabuchi, Moto Kitayama, Kayoko Matsushima, Naoyuki Yamaguchi, Hisayoshi Kondo, Fumihiko Fujita, Hiroaki Takeshita, Kazuhiko Nakao, Fuminao Takeshima
Summary: This study investigated the significance of palmitoleic acid (PO) levels in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD). The results showed that serum PO levels were significantly higher in CD patients compared to controls, and were associated with CD activity index and increased risk of surgical intervention requirement during follow-up. Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Sergi Casado-Llombart, Maria Velasco-de Andres, Cristina Catala, Alejandra Leyton-Pereira, Rebeca Gutierrez-Cozar, Belen Suarez, Noelia Armiger, Esther Carreras, Miriam Esteller, Elena Ricart, Ingrid Ordas, Javier P. Gisbert, Maria Chaparro, Maria Esteve, Lucia Marquez, David Busquets, Eva Iglesias, Esther Garcia-Planella, Maria Dolores Martin-Arranz, Juliane Lohmann, C. Korcan Ayata, Jan Hendrik Niess, Pablo Engel, Julian Panes, Azucena Salas, Eugeni Domenech, Francisco Lozano
Summary: The expression and variation of CD5 and CD6 may play a role in the pathophysiology of inflammatory bowel diseases, affecting their clinical manifestations and therapeutic requirements.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Shengjie Ma, Jiaxin Zhang, Heshi Liu, Shuang Li, Quan Wang
Summary: Macrophages play a significant role in the progression of inflammatory bowel disease (IBD) by regulating inflammatory phenotype. Further investigation of the role of macrophages in the pathogenesis of IBD will facilitate the development of novel treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ziling Zhou, Ziman Xiong, Ran Cheng, Qingyu Luo, Yuanqiu Li, Qingguo Xie, Peng Xiao, Daoyu Hu, Xuemei Hu, Yaqi Shen, Zhen Li
Summary: This study investigates the effectiveness of volumetric visceral adipose tissue (VAT) features extracted using radiomics and a three-dimensional convolutional neural network (3D-CNN) approach in differentiating Crohn's disease (CD) and ulcerative colitis (UC). The results show that radiomics analysis with the least absolute shrinkage and selection operator (LASSO) had the highest AUC value, indicating its potential diagnostic value. The developed 3D-CNN model and radiomics analysis with principal component analysis (PCA) also showed comparable performance in characterizing CD and UC. Clinical covariates were adjusted in the models, and the LASSO model with adjustment of clinical covariates reached the highest AUC value.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Montserrat Baldan-Martin, Maria Chaparro, Javier P. Gisbert
Summary: Inflammatory bowel disease is a global disease with challenges in understanding its complex pathogenesis and progression, leading to limited progress in diagnosis and treatment. Future studies are needed to comprehensively characterize the disease biology for early detection and monitoring of clinical outcomes.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hany H. Arab, Ahmed H. Eid, Ayman M. Mahmoud, Mahmoud A. Senousy
Summary: The study demonstrates that linagliptin has the potential to mitigate colitis severity in rats by targeting multiple inflammatory pathways and oxidative stress, suggesting its promise for managing IBD.
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shara Francesca Rapa, Rosanna Di Paola, Marika Cordaro, Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Giuseppina Autore, Salvatore Cuzzocrea, Hermann Stuppner, Stefania Marzocco
Summary: Intestinal epithelial barrier impairment is crucial in IBDs, especially in UC. Plumericin, a natural product, shows potential in improving barrier function and reducing apoptosis in both cell and animal experimental models of colitis. It enhances adhesion molecule expression, cytoskeleton rearrangement, and motility, while reducing apoptotic parameters.
Article
Biochemistry & Molecular Biology
Gwendoline Astre, Simon Deleruyelle, Alizee Dortignac, Christelle Bonnet, Philippe Valet, Cedric Dray
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Claire Vinel, Laura Lukjanenko, Aurelie Batut, Simon Deleruyelle, Jean-Philippe Pradere, Sophie Le Gonidec, Alizee Dortignac, Nancy Geoffre, Ophelie Pereira, Sonia Karaz, Umji Lee, Mylene Camus, Karima Chaoui, Etienne Mouisel, Anne Bigot, Vincent Mouly, Mathieu Vigneau, Allan F. Pagano, Angele Chopard, Fabien Pillard, Sophie Guyonnet, Matteo Cesari, Odile Burlet-Schiltz, Marco Pahor, Jerome N. Feige, Bruno Vellas, Philippe Valet, Cedric Dray
Review
Pharmacology & Pharmacy
Isabelle Castan-Laurell, Bernard Masri, Philippe Valet
EXPERT OPINION ON THERAPEUTIC TARGETS
(2019)
Article
Oncology
Victor Laurent, Aurelie Toulet, Camille Attane, Delphine Milhas, Stephanie Dauvillier, Falek Zaidi, Emily Clement, Mathieu Cinato, Sophie Le Gonidec, Adrien Guerard, Camille Lehuede, David Garandeau, Laurence Nieto, Edith Renaud-Gabardos, Anne-Catherine Prats, Philippe Valet, Bernard Malavaud, Catherine Muller
MOLECULAR CANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Anne-Charlotte Jarry, Nadir Merah, Fanta Cisse, Florence Cayetanot, Marie-Noelle Fiamma, Alexandra Willemetz, Dalale Gueddouri, Besma Barka, Philippe Valet, Sandra Guilmeau, Andre Bado, Johanne Le Beyec, Laurence Bodineau, Maude Le Gall
Article
Neurosciences
Marion Rincel, Maiwenn Olier, Amandine Minni, Camille Monchaux de Oliveira, Yann Matime, Eric Gaultier, Isabelle Grit, Jean-Christophe Helbling, Anna Maria Costa, Amandine Lepinay, Marie-Pierre Moisan, Sophie Laye, Laurent Ferrier, Patricia Parnet, Vassilia Theodorou, Muriel Darnaudery
PSYCHOPHARMACOLOGY
(2019)
Article
Microbiology
Oceane C. B. Martin, Maiwenn Olier, Sandrine Ellero-Simatos, Nathalie Naud, Jacques Dupuy, Laurence Huc, Sylviane Tache, Vanessa Graillot, Mathilde Leveque, Valerie Bezirard, Cecile Helies-Toussaint, Florence Blas Y. Estrada, Valerie Tondereau, Yannick Lippi, Claire Naylies, Lindsey Peyriga, Cecile Canlet, Anne Marie Davila, Francois Blachier, Laurent Ferrier, Elisa Boutet-Robinet, Francoise Gueraud, Vassilia Theodorou, Fabrice H. F. Pierre
Article
Multidisciplinary Sciences
Claire Vinel, Joost P. Schanstra, Franck Boizard, Ophelie Pereira, Johanna Auriau, Alizee Dortignac, Benjamin Breuil, Guylene Feuillet, Esther Nkuipou-Kenfack, Petra Zuerbig, Philippe Valet, Jean-Loup Bascands, Cedric Dray, Colette Denis
SCIENTIFIC REPORTS
(2019)
Article
Hematology
Marie Bellio, Cedric Garcia, Thomas Edouard, Sophie Voisin, Benjamin G. Neel, Cendrine Cabou, Philippe Valet, Jun Mori, Alexandra Mazharian, Yotis A. Senis, Armelle Yart, Bernard Payrastre, Sonia Severin
Article
Biochemistry & Molecular Biology
Laurent Ferrier, Helene Eutamene, Lea Siegwald, Andrea M. Marquard, Valerie Tondereau, Julien Chevalier, Guillaume E. Jacot, Laurent Favre, Vassilia Theodorou, Maria Vicario, Andreas Rytz, Gabriela Bergonzelli, Clara L. Garcia-Rodenas
Summary: The study found that human milk oligosaccharides (HMOs) can impact visceral hypersensitivity (VHS) and alleviate abdominal pain. HMOs have the ability to modulate the microbiota, gut, and brain, playing a role in regulating pain-related functional gastrointestinal disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Oncology
Camille Lehuede, Xia Li, Stephanie Dauvillier, Charlotte Vaysse, Camille Franchet, Emily Clement, David Esteve, Melanie Longue, Leonor Chaltiel, Sophie Le Gonidec, Ikrame Lazar, Aline Geneste, Charles Dumontet, Philippe Valet, Laurence Nieto, Frederique Fallone, Catherine Muller
BREAST CANCER RESEARCH
(2019)
Article
Endocrinology & Metabolism
Chantal Bertrand, Jean-Philippe Pradere, Nancy Geoffre, Simon Deleruyelle, Bernard Masri, Jean Personnaz, Sophie Le Gonidec, Aurelie Batut, Katie Louche, Cedric Moro, Philippe Valet, Isabelle Castan-Laurell
Letter
Gastroenterology & Hepatology
O. Inczefi, V. Bacquie, M. Olier-Pierre, M. Rincel, B. Ringot-Destrez, S. Ellero-Simatos, H. Eutamene, C. Betoulieres, J. Thomas, J. Laine, L. Gros, M. Leveque, R. Leonard, C. Harkat, C. Robbe-Masselot, R. Roka, M. Mercier-Bonin, V. Theodorou, M. Darnaudery, J. R. Turner, L. Ferrier
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Endocrinology & Metabolism
Pierre Gourdy, Laurent Cazals, Claire Thalamas, Agnes Sommet, Fabienne Calvas, Monique Galitzky, Claire Vinel, Cedric Dray, Helene Hanaire, Isabelle Castan-Laurell, Philippe Valet
DIABETES OBESITY & METABOLISM
(2018)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.