Article
Medicine, Research & Experimental
Shaimaa S. El-Sayed, Rania M. Shahin, Ahmed Fahmy, Shimaa M. Elshazly
Summary: The study investigated the cardioprotective effects of quercetin against remote cardiomyopathy induced by renal ischemia/reperfusion. Quercetin was shown to reverse renal I/R induced damages through regulation of Rho-kinase pathway and H2S production.
Article
Biochemistry & Molecular Biology
Mathias Clarysse, Alison Accarie, Arnau Panisello-Rosello, Ricard Farre, Emilio Canovai, Diethard Monbaliu, Gert De Hertogh, Tim Vanuytsel, Jacques Pirenne, Laurens J. Ceulemans
Summary: Intestinal ischemia-reperfusion injury (IRI) is a common clinical condition with unpredictable outcomes. Polyethylene glycol (PEG), a commonly used excipient, has been found to have anti-inflammatory and cell-membrane-stabilizing properties. This study investigated the effects of PEG administration on IRI in rats and found that it reduced reperfusion edema, bacterial translocation, inflammatory reaction, and improved survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Fan Deng, Ze-Bin Lin, Qi-Shun Sun, Yue Min, Yue Zhang, Yu Chen, Wen-Ting Chen, Jing-Juan Hu, Ke-Xuan Liu
Summary: Intestinal ischemia/reperfusion (I/R) is a common pathological process in severely ill patients, and the impact of intestinal I/R injury on the overall systemic state of the patient is greater than that of primary intestinal injury. Recent evidence suggests that intestinal microbiota and its metabolites play a crucial role in the occurrence, development, diagnosis, and treatment of intestinal I/R injury. Targeting the intestinal microbiota and its metabolites may be an effective therapy for treating intestinal I/R injury and associated extraintestinal organ injuries.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Zhou Zhongyin, Wang Wei, Xiong Juan, Fan Guohua
Summary: This study discovered that Isoliquiritin apioside (IA) can protect against intestinal ischemia/reperfusion (I/R)-induced acute lung injury (ALI) by reducing lung epithelial ferroptosis in a Hif-1 alpha dependent manner.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Wenjun Li, Yuriko Terada, Yulia Y. Tyurina, Vladimir A. Tyurin, Amit Bery, Jason M. Gauthier, Ryuji Higashikubo, Alice Y. Tong, Dequan Zhou, Felix Nunez-Santana, Emilia Lecuona, Adil Hassan, Kohei Hashimoto, Davide Scozzi, Varun Puri, Ruben G. Nava, Alexander S. Krupnick, Kory J. Lavine, Andrew E. Gelman, Mark J. Miller, Valerian E. Kagan, Ankit Bharat, Daniel Kreisel
Summary: Ischemia reperfusion injury is a common pathological condition triggered by the release of endogenous ligands. In this study, the researchers discovered that necroptosis, a nonapoptotic form of cell death, triggers the recruitment of neutrophils in injured lungs. Initially, neutrophils traffic predominantly to subpleural vessels, guided by chemoattractants produced by nonclassical monocytes. The disruption of pulmonary capillaries by neutrophils leads to vascular leakage and impaired graft function. The study also found that TLR4 signaling and NADPH oxidase 4 expression mediate the arrest of neutrophils, preventing their extravasation. The formation of neutrophil extracellular traps in injured lungs can be disrupted with DNase to prevent vascular leakage and improve graft dysfunction. These findings could have important implications for the development of therapeutics to protect lungs from ischemia reperfusion injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Mathias Clarysse, Alison Accarie, Ricard Farre, Emilio Canovai, Diethard Monbaliu, Jan Gunst, Gert De Hertogh, Tim Vanuytsel, Jacques Pirenne, Laurens J. J. Ceulemans
Summary: Animal research on intestinal ischemia-reperfusion injury (IRI) is mainly done using rodent models. Previously, intraperitoneal injections with ketamine-xylazine mixtures were common, but now volatile anesthetics like isoflurane are more commonly used. However, the impact of the anesthetic method on intestinal IRI has not been studied. This study aims to analyze the different anesthetic methods and their influence on the extent of intestinal IRI in a rat model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Wenlian Li, Kejia Yang, Bin Li, Yunxiang Wang, Jing Liu, Dapeng Chen, Yunpeng Diao
Summary: In this study, Cor was found to effectively alleviate intestinal and lung damage caused by intestinal ischemia reperfusion (II/R) by inhibiting NLRP3 inflammasome activation and pyroptosis. This suggests that Cor may be a potential therapeutic agent for inflammation and tissue injury induced by II/R.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Toshihiro Okamoto, Hiromichi Niikawa, David Wheeler, Basem Soliman, Kamal S. Ayyat, Yoshifumi Itoda, Carol F. Farver, Kenneth R. McCurry
Summary: The study findings suggest that lung weight at donor hospital, lung weight change during EVLP, and lung weight at 2 h of EVLP may serve as predictors of P/F ratio and transplant suitability in cellular EVLP.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yiru Guo, Qianhong Li, Yu-Ting Xuan, Wen-Jian Wu, Wei Tan, Jan Slezak, Xiaoping Zhu, Alex Tomlin, Roberto Bolli
Summary: This study demonstrates that short-term, mild exercise induces delayed cardioprotective effects against myocardial infarction, dependent on the activation of eNOS, eNOS-derived NO generation, and subsequent PKC epsilon activation during preconditioning. Furthermore, the protection 24 hours after exercise is mediated by iNOS activity.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mei Yang, Yu-Xia Ma, Ying Zhi, Hai-Bin Wang, Li Zhao, Peng-Sheng Wang, Jie-Ting Niu
Summary: The study demonstrated that C-176 significantly attenuated acute lung injury induced by intestinal ischemia-reperfusion, potentially through activation of the AMPK signaling pathway.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Taslim A. Al-Hilal, Mohammad Anwar Hossain, Ahmed Alobaida, Farzana Alam, Ali Keshavarz, Eva Nozik-Grayck, Kurt R. Stenmark, Nadezhda A. German, Fakhrul Ahsan
Summary: The study developed a hypoxia-activated prodrug of fasudil that selectively suppresses ROCK activity under hypoxic conditions, exhibiting antiproliferative effects on disease-afflicted pulmonary arterial smooth muscle cells and pulmonary arterial endothelial cells. The prodrug has a long plasma half-life and does not affect systemic blood pressure.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Miriam M. Cortese-Krott, Tatsiana Suvorava, Francesca Leo, Sophia K. Heuser, Anthea LoBue, Junjie Li, Stefanie Becher, Rebekka Schneckmann, Tanu Srivrastava, Ralf Erkens, Georg Wolff, Joachim P. Schmitt, Maria Grandoch, Jon O. Lundberg, John Pernow, Brant E. Isakson, Eddie Weitzberg, Malte Kelm
Summary: This study reveals that red blood cell endothelial nitric oxide synthase (RBC eNOS) plays a role in limiting infarct size in acute myocardial infarction (AMI) and regulates coronary blood flow and cardiac function. These findings suggest that RBC eNOS signaling may represent a novel target for interventions in ischemia/reperfusion after myocardial infarction.
Article
Biochemistry & Molecular Biology
Zhe Liu, Guangze Mou, Zhiming Liang, Rui Zhao, Chenghao Jin, Rui Wu
Summary: The study found that selenomethionine (SeMet) can alleviate intestinal ischemia-reperfusion injury by increasing antioxidant levels and inhibiting the expression of apoptosis-related proteins.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Medicine, Research & Experimental
Gehui Li, Min Xu, Hao Wang, Xiaofei Qi, Xiaoguang Wang, Yong Li, Jing Sun, Yuantao Li
Summary: The study revealed that pre-treatment with the miR-146a overexpression vector alleviated intestinal I/R-induced acute lung injury in mice, reducing the expression levels of inflammatory cytokines and apoptosis-related proteins.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lu-Yuan Peng, Hai-Tao Shi, Yue-Rong Tan, Si-Yang Shen, Peng-Fei Yi, Hai-Qing Shen, Ben-Dong Fu
Summary: The study found that baicalin protected against APEC infection by modulating gut microbiota, increasing short chain fatty acid (SCFA) production, especially acetate. Acetate may circulate to the lungs to activate FFAR2 to defend against APEC infection.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.