Article
Nutrition & Dietetics
Chaowen Ge, Yuqin Peng, Jiacheng Li, Lei Wang, Xiaoyu Zhu, Ning Wang, Dongmei Yang, Xian Zhou, Dennis Chang
Summary: This study investigated the protective effects of Hydroxysafflor yellow A (HSYA) against myocardial ischemia/reperfusion injury (MI/RI) and identified the underlying mechanisms. HSYA reduced myocardial histopathological damage, ameliorated mitochondrial damage, and decreased iron contents in myocardial tissue. It activated the HIF-1a/SLC7A11/GPX4 signaling pathway to inhibit ferroptosis, thereby alleviating MI/RI.
Review
Cell Biology
Shu Xu, Yao He, Lihui Lin, Peng Chen, Minhu Chen, Shenghong Zhang
Summary: Ferroptosis is a newly recognized type of regulated cell death characterized by iron-dependent accumulation of lipid peroxidation, which is significantly distinct from other forms of cell death at morphological, biochemical, and genetic levels. Recent studies have linked ferroptosis to various diseases, including neurological disorders, kidney injury, liver diseases, and cancer, as well as dysfunction of the intestinal epithelium, which contributes to intestinal diseases.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Benedikt Kolbrink, Friedrich Alexander von Samson-Himmelstjerna, Maja Lucia Messtorff, Theresa Riebeling, Raphael Nische, Jessica Schmitz, Jan Hinrich Brasen, Ulrich Kunzendorf, Stefan Krautwald
Summary: Ferroptosis, a type of iron-dependent programmed cell death, plays a vital role in multiple diseases. However, there are no pharmacologic inhibitors of ferroptosis in clinical use. In this study, vitamin K1 was identified as an efficient inhibitor of ferroptosis, providing a new strategy for pharmacological control of this mode of cell death.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Lijuan Ma, Xueqi Liu, Mengya Zhang, Lang Zhou, Ling Jiang, Li Gao, Xian Wang, Yuebo Huang, Hanxu Zeng, Yonggui Wu
Summary: This article discusses the complicated pathophysiological mechanism of acute kidney injury (AKI) and the lack of effective drugs. It also introduces a newly discovered cell death mode called ferroptosis, which is involved in the progression of AKI. Paeoniflorin (PF), a traditional Chinese medicine, has protective effects on kidney diseases including AKI, but the mechanism of PF in attenuating AKI is unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiahong Yang, Xiaolin Sun, Ning Huang, Peng Li, Jiaqi He, Lan Jiang, Xuemei Zhang, Shu Han, Hong Xin
Summary: Entacapone, a specific inhibitor of catechol-O-methyltransferase, has been shown to prevent renal ischemia/reperfusion-induced injury by inhibiting ferroptosis and enhancing antioxidant capacity.
Article
Chemistry, Physical
Xishao Xie, Yunjing Zhang, Xinwan Su, Junni Wang, Xi Yao, Dou Lv, Qin Zhou, Jianhua Mao, Jianghua Chen, Fei Han, Yangyang Li, Weiqiang Lin
Summary: This study synthesized gallic acid-gallium polyvinyl pyrrolidone nanoparticles (GGP NPs) as a potential iron-scavenging agent and demonstrated their good biocompatibility and protective effects in inhibiting ferroptosis. Treatment with GGP NPs significantly ameliorated renal injury and mitochondrial damage, making them a potential candidate for AKI treatment.
Article
Gastroenterology & Hepatology
Fan Deng, Bing-Cheng Zhao, Xiao Yang, Ze-Bin Lin, Qi-Shun Sun, Yi-Fan Wang, Zheng-Zheng Yan, Wei-Feng Liu, Cai Li, Jing-Juan Hu, Ke-Xuan Liu
Summary: Intestinal ischemia/reperfusion (I/R) injury disrupts gut microbiota and causes significant changes in metabolites, while capsiate (CAT), a gut microbiota metabolite, can alleviate ferroptosis-dependent intestinal I/R injury.
Article
Immunology
Lin Zhu, Wanyi Lian, Zhiwen Yao, Xiao Yang, Ziyi Wang, Yupei Lai, Shiting Xu, Bingcheng Zhao, Kexuan Liu
Summary: This study identified genes related to ferroptosis and immunity in intestinal I/R injury and predicted their correlations. It also provided potential transcription factor-gene networks and therapeutic targets, offering clues for further investigation of intestinal I/R injury.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Santosh K. Panda, Vincent Peng, Raki Sudan, Susan Gilfillan, Marina Cella, Alina Ulezko, Blanda Di Luccia, Takahiro E. Ohara, Jose Luis Fachi, Gary E. Grajales-Reyes, Alina Natalia, Tihana Trsan, Susan Gilfilan, Marina Cella, Marco Colonna
Summary: This study demonstrates the vital role of AHRR in sustaining intestinal intraepithelial lymphocytes (IELs). AHRR deficiency leads to oxidative stress, lipid peroxidation, and ferroptosis in Ahrr-/- IELs, which can be rescued by dietary supplementation with selenium or vitamin E. Reduced expression of AHRR in inflammatory bowel disease patients may contribute to disease progression.
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Xue Yang, Jianjiang Wu, Hu Cheng, Siyu Chen, Jiang Wang
Summary: This study aimed to investigate the mechanism and effect of Dexmedetomidine (Dex) on brain damage after myocardial ischemia/reperfusion (IR) injury. The results showed that Dex could alleviate brain damage induced by myocardial IR, including inflammatory response, blood-brain barrier disruption, neuronal edema, microglial activation, and cognitive dysfunction. Furthermore, the neuroprotective effect of Dex was found to be partially dependent on the activation of the HIF-1 pathway.
Article
Critical Care Medicine
Zhenqian Lv, Feng'e Wang, Xingfeng Zhang, Xiting Zhang, Jing Zhang, Ran Liu
Summary: Etomidate (Eto) attenuated myocardial ischemia reperfusion injury (MIRI) by inhibiting ferroptosis via the Nrf2 pathway, demonstrating anti-inflammatory and anti-fibrotic effects in MIRI rats.
Article
Medicine, General & Internal
Xiujie Liu, Binhui Pan, Xiaoting Wang, Junpeng Xu, Xinyu Wang, Zhengyang Song, Eryao Zhang, Fangyan Wang, Wantie Wang
Summary: This study evaluated the link between ferroptosis and inflammation in lung ischemia/reperfusion injury (LIRI) at different time points. The results showed that pro-ferroptotic indicators were upregulated while anti-ferroptotic factors were downregulated. At later time points, the levels of pro-inflammatory cytokines were increased. Blocking ferroptosis alleviated lung injury and inhibited inflammation. These findings suggest that inhibiting ferroptosis may have therapeutic potential for LIRI.
FRONTIERS IN MEDICINE
(2023)
Article
Cell Biology
Zhaohui Liu, Yanli Meng, Yu Miao, Lili Yu, Qiannan Yu
Summary: Propofol can suppress pyroptosis in rI/R-induced ALI by upregulating SIRT1, reducing lung injury and inflammatory cell infiltration.
Article
Multidisciplinary Sciences
Samia Adel Abd El-Baset, Manal R. Abd El-haleem, Rehab S. Abdul-Maksoud, Asmaa A. A. Kattaia
Summary: Mesna demonstrates beneficial effects in acute lung damage caused by intestinal ischemia-reperfusion, including alleviating histopathological changes, reducing apoptosis, improving systemic oxygenation, inhibiting inflammation, and enhancing antioxidant capacity.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Wenyang Jiang, Jindan Kai, Donghang Li, Zhongheng Wei, Ying Wang, Wei Wang
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Wei Wang, Ning-yuan Chen, Dewei Ren, Jonathan Davies, Kemly Philip, Holger K. Eltzschig, Michael R. Blackburn, Bindu Akkanti, Harry Karmouty-Quintana, Tingting Weng
Summary: The study demonstrates the protective effects of dipyridamole in promoting adenosine accumulation in acute lung injury, highlighting the role of ADORA2B as a key mediator in resolving ALI.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Zhou Zhongyin, Wang Wei, Xiong Juan, Fan Guohua
Summary: This study found that epigallocatechin gallate (EG), a natural polyphenol extracted from green tea, could improve PM2.5-induced lung fibrosis by reducing oxidative damage and epithelial-mesenchymal transition (EMT) through the AKT/mTOR pathway. Intragastric administration of EG prevented lung injury, inflammation, and oxidative stress in mice exposed to PM2.5. In vitro experiments showed that EG treatment enhanced cell viability in PM2.5-treated lung epithelial cells. Overexpression of AKT offset the inhibitory effects of EG on EMT and oxidative stress. EG may be a potential candidate for the treatment of PM2.5-induced lung fibrosis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Bo -Lin Xiao, Xiao-Le Wang, Hou-Fu Xia, Kui-Ming Wang, Zhuo-Kun Chen, Ya-Hua Zhong, Huan-Gang Jiang, Fu-Xiang Zhou, Wei Wang, Gai-Li Chen, Gang Chen
Summary: In this study, it was discovered that the core component of ESCRT-0, HRS, plays a crucial role in regulating the secretion of sEV PD-L1 and is associated with the response to ICB therapy in patients with HNSCC. Knockdown of HRS significantly reduced the expression of PD-L1 in HNSCC cell-derived sEVs and attenuated their immunosuppressive effects on CD8+ T cells. Additionally, higher HRS expression was found to be associated with a lower response rate to anti-PD-1 therapy in HNSCC patients. Overall, these findings suggest that HRS is a promising target for improving cancer immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Liping Zhu, Dafu Ye, Tianyu Lei, Jie Wu, Wei Wang, Bin Xu
Summary: Although immune checkpoint inhibitors (ICIs) have shown remarkable efficacy in treating non-small cell lung cancer (NSCLC), it is challenging to accurately predict which patients will respond to ICIs using conventional criteria. Previous studies have suggested that specific gene mutations may play a role in immunotherapy response, but the predictive value of single gene mutations may be limited. With advances in sequencing technology, it has been discovered that multiple mutations often co-occur and can synergistically affect signaling pathways involved in anti-tumor immune responses. Therefore, the mutation profile, especially co-mutations, of patients may be an important consideration for predicting the efficacy of ICIs.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ning Li, Wei Wang, Heng Zhou, Qingqing Wu, Mingxia Duan, Chen Liu, Haiming Wu, Wei Deng, Difei Shen, Qizhu Tang
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Oncology
Li Ning, Wang Wei, Jiang Wenyang, Xiong Rui, Geng Qing
CLINICAL AND TRANSLATIONAL MEDICINE
(2020)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
