Article
Pharmacology & Pharmacy
Haiyan Liu, Ziping Li, Fei Qiu, Chunjie Li, Xiaojing Lin, Yingyi He, Maoxiang Qian, Yuanbin Song, Hui Zhang
Summary: This study investigated the association between NR3C1 gene mutations and treatment outcomes in pediatric acute lymphoblastic leukemia (ALL), finding that NR3C1 mutations are associated with glucocorticoid resistance. Loss-of-function (LoF) NR3C1 mutations influence GC resistance, indicating that NR3C1 alterations play a critical role in GC resistance and may contribute to treatment failure and relapse in ALL.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Lilly Velentza, Farasat Zaman, Lars Savendahl
Summary: GCs are widely used in the treatment of childhood ALL but their long-term use is associated with bone-related morbidities. Unfortunately, there is currently no efficient treatment for bone health impairment in patients and survivors. The review aims to discuss how GCs impact bone health in pediatric ALL and efforts made to minimize these side effects.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ute I. Schwarz, Morgan Woldanski-Travaglini, Valerie Swanston, Mariam Mikhail, Chantel Cacciotti, Elizabeth Cairney, Serina Patel, Jennifer Seelisch, Soumitra Tole, Marta Wilejto, Rommel G. Tirona, Richard B. Kim, Alexandra P. Zorzi
Summary: Mercaptopurine is a crucial drug for maintenance chemotherapy in childhood acute lymphoblastic leukemia, but patients with TPMT deficiency are at greater risk for toxicity. Genotype-guided dose adjustment is recommended to reduce side effects.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Article
Biochemistry & Molecular Biology
Jacobus C. Buurstede, Susana N. Paul, Karolien De Bosscher, Onno C. Meijer, Jan Kroon
Summary: Glucocorticoids exert their effects by activating the glucocorticoid receptor (GR) throughout the body. This study investigated the interaction between glucocorticoids and androgen signaling in the liver transcriptome. The results showed that a substantial proportion of the hepatic transcriptome is androgen-dependent after chronic exposure, while the effects of glucocorticoids are largely androgen-independent after acute exposure. The study suggests that prolonged glucocorticoid exposure may upregulate androgen receptor expression, leading to androgen dependence not driven by direct interactions between the androgen receptor and glucocorticoid receptor.
Review
Oncology
Marta Malczewska, Kamil Kosmider, Kinga Bednarz, Katarzyna Ostapinska, Monika Lejman, Joanna Zawitkowska
Summary: Acute lymphoblastic leukemia is the most common blood cancer in pediatric patients. Despite significant progress in treatment, some patients cannot be saved. Conventional methods of treatment carry high toxicities, reducing effectiveness and sometimes leading to death. Novel treatments, including targeted treatment, CAR-T-cell therapy, and immunotherapy, are being explored.
Review
Oncology
Marina Oldenburg, Nadine Ruechel, Stefan Janssen, Arndt Borkhardt, Katharina L. Goessling
Summary: The concept of holobionts emphasizes the complex interactions between a host and other species, which, if disturbed may lead to disease and premature aging. The impact of chemotherapy on the microbiome and long-term dysbiosis in survivors of acute lymphoblastic leukemia requires further research.
Article
Medicine, Research & Experimental
Yizhen Li, Wentao Yang, Meenakshi Devidas, Stuart S. Winter, Chimene Kesserwan, Wenjian Yang, Kimberly P. Dunsmore, Colton Smith, Maoxiang Qian, Xujie Zhao, Ranran Zhang, Julie M. Gastier-Foster, Elizabeth A. Raetz, William L. Carroll, Chunliang Li, Paul P. Liu, Karen R. Rabin, Takaomi Sanda, Charles G. Mullighan, Kim E. Nichols, William E. Evans, Ching-Hon Pui, Stephen P. Hunger, David T. Teachey, Mary Relling, Mignon L. Loh, Jun J. Yang
Summary: Genetic alterations in the RUNX1 gene are associated with various blood disorders, especially those of the megakaryocyte and myeloid lineages. Germline RUNX1 variants have different effects on B-ALL and T-ALL, with the latter showing severe damaging effects. Additionally, JAK3 mutation is a common somatic genomic abnormality in T-ALL with germline RUNX1 variants.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Marieta Xagorari, Antonios Marmarinos, Lydia Kossiva, Margarita Baka, Dimitrios Doganis, Marina Servitzoglou, Maria Tsolia, Andreas Scorilas, Margaritis Avgeris, Dimitrios Gourgiotis
Summary: The study evaluated the prognostic utility of GAS5 in childhood acute lymphoblastic leukemia (chALL), finding that GAS5 overexpression was strongly associated with a higher risk for short-term relapse and poor treatment outcome, independently of patients' clinicopathological data. Moreover, multivariate models incorporating GAS5 levels resulted in superior risk stratification and clinical benefit for chALL prognostication, supporting personalized prognosis and precision medicine decisions in chALL.
Review
Immunology
Shanie Saghafian-Hedengren, Eva Sverremark-Ekstrom, Anna Nilsson
Summary: The article summarizes the role of the immune system in recognizing and eliminating malignant cells, and discusses the potential challenges faced by T-cell immunotherapies targeting pediatric cancers in early life stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yuting Zhu, Xiaopeng Ma, Heng Zhang, Yijun Wu, Meiyun Kang, Yongjun Fang, Yao Xue
Summary: The study revealed that circADD2 is down-regulated in ALL, and its overexpression inhibits cell proliferation while promoting apoptosis. circADD2 functions by directly sponging miR-149-5p.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Gabriela Burgueno-Rodriguez, Yessika Mendez, Natalia Olano, Magdalena Schelotto, Luis Castillo, Ana Maria Soler, Julio da Luz
Summary: This study aims to identify genetic variants related to drugs used in the treatment of pediatric acute lymphoblastic leukemia in Uruguay and analyze their contribution to adverse effects. The study found that mucositis, Cushing syndrome, and neurotoxicity were linked to specific genetic variants and individual genetic ancestry.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Thies Bartram, Peter Schuette, Anja Moericke, Richard S. Houlston, Eva Ellinghaus, Martin Zimmermann, Anke Bergmann, Britt-Sabina Loescher, Norman Klein, Laura Hinze, Stefanie Junk, Michael Forster, Claus R. Bartram, Rolf Koehler, Andre Franke, Martin Schrappe, Christian P. Kratz, Gunnar Cario, Martin Stanulla
Summary: Genetic variation in the ABCC4 gene was found to be associated with AP during ALL treatment, while no association was observed with the CFTR gene. Replication confirmed the ABCC4 variants but not the CFTR variant. Larger international studies are needed to more conclusively assess the risk of rare clinical phenotypes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Nicolas C. Nicolaides
Summary: Glucocorticoid receptors play a crucial role in various cellular processes and physiological functions. Recent studies have shown that the beta isoform of the receptor, GR beta, has important functions in cellular homeostasis and is involved in endocrine physiology and pathophysiology.
Review
Oncology
Laure Angot, Pascale Schneider, Jean-Pierre Vannier, Souleymane Abdoul-Azize
Summary: Although progress has been made in the treatment of acute lymphoblastic leukemia (ALL), relapse and resistance to therapy remain significant challenges. This article reviews the mechanisms of resistance in ALL and explores the therapeutic potential of targeting signaling pathways. Of particular interest is the paradoxical role of glucocorticoids (GCs) in promoting cell survival and resistance to therapy in ALL cells. Understanding these pathways could lead to improved treatment strategies for ALL.
Article
Genetics & Heredity
Maria Plesa, Vincent Gagne, Sanja Glisovic, Melissa Younan, Bahram Sharif-Askari, Caroline Laverdiere, Nathalie Alos, Jean-Marie Leclerc, Stephen E. Sallan, Donna Neuberg, Jeffery L. Kutok, Lewis B. Silverman, Daniel Sinnett, Maja Krajinovic
PHARMACOGENOMICS JOURNAL
(2019)
Article
Nutrition & Dietetics
E. Delvin, N. Alos, F. Rauch, V. Marcil, S. Morel, M. Boisvert, M. -A. Lecours, C. Laverdiere, D. Sinnett, M. Krajinovic, J. Dubois, S. Drouin, G. Lefebvre, M. Samoilenko, C. Nyalendo, E. Cavalier, E. Levy
CLINICAL NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Fida Khater, Sylvie Langlois, Pauline Cassart, Anne-Marie Roy, Mathieu Lajoie, Jasmine Healy, Chantal Richer, Pascal St-Onge, Nelson Piche, Sebastien Perreault, Sonia Cellot, Monia Marzouki, Nada Jabado, Daniel Sinnett
Article
Cardiac & Cardiovascular Systems
Maxime Caru, Denis Corbin, Delphine Perie, Valerie Lemay, Jacques Delfrate, Simon Drouin, Laurence Bertout, Maja Krajinovic, Caroline Laverdiere, Gregor Andelfinger, Daniel Sinnett, Daniel Curnier
CLINICAL RESEARCH IN CARDIOLOGY
(2019)
Article
Genetics & Heredity
Yosr Hamdi, Martin Leclerc, Martine Dumont, Stephane Dubois, Martine Tranchant, Guy Reimnitz, Penny Soucy, Pauline Cassart, Manon Ouimet, Daniel Sinnett, M'Hamed Lajmi Lakhal Chaieb, Jacques Simard
Article
Oncology
Maxime Caru, Kateryna Petrykey, Simon Drouin, Patrick Beaulieu, Pascal St-Onge, Valerie Lemay, Laurence Bertout, Caroline Laverdiere, Gregor Andelfinger, Maja Krajinoyic, Daniel Sinnett, Daniel Curnier
Article
Health Care Sciences & Services
Miguel Caubet Fernandez, Simon Drouin, Mariia Samoilenko, Sophia Morel, Maja Krajinovic, Caroline Laverdiere, Daniel Sinnett, Emile Levy, Valerie Marcil, Genevieve Lefebvre
BMC MEDICAL RESEARCH METHODOLOGY
(2019)
Article
Peripheral Vascular Disease
Ku-Geng Huo, Chantal Richer, Olga Berillo, Nada Mahjoub, Julio C. Fraulob-Aquino, Tlili Barhoumi, Sofiane Ouerd, Suellen C. Coelho, Daniel Sinnett, Pierre Paradis, Ernesto L. Schiffrin
Article
Pharmacology & Pharmacy
Michelle Aaron, Genevieve Nadeau, Erika Ouimet-Grennan, Simon Drouin, Laurence Bertout, Patrick Beaulieu, Pascal St-Onge, Albert Shalmiev, Louis-Nicolas Veilleux, Frank Rauch, Kateryna Petrykey, Caroline Laverdiere, Daniel Sinnett, Nathalie Alos, Maja Krajinovic
Article
Oncology
Aubree Boulet-Craig, Philippe Robaey, Fanny Barlaam, Julie Laniel, Victor Oswald, Karim Jerbi, Serge Sultan, Laurence Affret-Bertout, Simon Drouin, Maja Krajinovic, Caroline Laverdiere, Daniel Sinnett, Pierre Jolicoeur, Sarah Lippe
Article
Oncology
Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gael Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Flores-Diaz, Andre Haman, Trang Hoang, Daniel Sinnett, Christian Beausejour, Serge McGraw, Noel J. -M. Raynal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Meeting Abstract
Sport Sciences
Maxime Caru, Kateryna Petrykey, Mariia Samoilenko, Simon Drouin, Valerie Lemay, Laurence Kern, Lucia Romo, Patrick Beaulieu, Pascal St-Onge, Laurence Bertout, Genevieve Lefebvre, Caroline Leverdiere, Gregor Andelfinger, Maja Krajinovic, Daniel Sinnett, Daniel Curnier
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Nutrition & Dietetics
Sophie Berard, Sophia Morel, Emma Teasdale, Nitin Shivappa, James R. Hebert, Caroline Laverdiere, Daniel Sinnett, Emile Levy, Valerie Marcil
Article
Pediatrics
Johanne Kerba, Catherine Demers, Veronique Belanger, Melanie Napartuk, Isabelle Bouchard, Caroline Meloche, Sophia Morel, Nicolas Prud'homme, Isabelle Gelinas, Johanne Higgins, Daniel Curnier, Serge Sultan, Caroline Laverdiere, Daniel Sinnett, Valerie Marcil
Summary: This study aims to assess the needs, barriers and facilitators to healthy lifestyle promotion interventions for adolescents with cancer. The findings suggest that adolescents with cancer need activities adapted to their age, peer support, and support to maintain their education and friendships. Lack of motivation, fatigue, and treatment side effects are reported as barriers to intervention.
Article
Pediatrics
Melanie Napartuk, Veronique Belanger, Isabelle Bouchard, Caroline Meloche, Daniel Curnier, Serge Sultan, Caroline Laverdiere, Daniel Sinnett, Valerie Marcil
Summary: This study examined the changes in diet and anthropometric and cardiometabolic profiles of children and adolescents undergoing cancer treatments after a one-year nutritional intervention. It found that the intervention improved diet quality and adherence, as well as weight, BMI, HDL-C levels, and vitamin D levels.
