Article
Cardiac & Cardiovascular Systems
Rasmus Dreier, Ulrik B. Andersen, Julie L. Forman, Majid Sheykhzade, Martin Egfjord, Jorgen L. Jeppesen
Summary: Increasing potassium intake raises plasma potassium and aldosterone levels, potentiating AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics in healthy normotensive men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng
Summary: The study revealed that TMAO can enhance Ang II-induced hypertension and mediate Ang II-induced vasoconstriction, possibly through the PERK/ROS/CaMKII/PLC beta 3 pathway.
Article
Chemistry, Medicinal
Qi Zhang, Yue Shen, Sayeman Islam Niloy, Stephen T. O'Rourke, Chengwen Sun
Summary: This study found that chronic infusion of apelin-13 does not change blood pressure or heart rate, and does not alter Ang II-induced hypertension and cardiac hypertrophy. These findings suggest that an APJ receptor biased agonist could be a better therapeutic alternative for treatment of hypertension.
Article
Cell Biology
Vanessa Oliveira, Ruth A. Riedl, Kristin E. Claflin, Natalia M. Mathieu, McKenzie L. Ritter, Kirthikaa Balapattabi, Kelsey K. Wackman, John J. Reho, Daniel T. Brozoski, Donald A. Morgan, Huxing Cui, Kamal Rahmouni, Colin M. L. Burnett, Pablo Nakagawa, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe
Summary: The brain renin-angiotensin system plays a role in the regulation of blood pressure, fluid intake, and energy expenditure. Leptin and angiotensin II in the brain stimulate energy expenditure through a shared mechanism. The metabolic effects of leptin depend on MC4R signaling.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Peripheral Vascular Disease
Ye Feng, Kexin Peng, Renfei Luo, Fei Wang, Tianxin Yang
Summary: The activation of PRR contributes to elevated blood pressure during Ang II infusion by enhancing intrarenal RAS and renal medullary alpha-ENaC. The study found that S1P-derived sPRR mediates Ang II-induced hypertension through an increase in intrarenal renin levels and activation of ENaC.
Article
Peripheral Vascular Disease
Mario Zanaty, Fernando A. C. Seara, Pablo Nakagawa, Guorui Deng, Natalia M. Mathieu, Kirthikaa Balapattabi, Sadashiva S. Karnik, Justin L. Grobe, Curt D. Sigmund
Summary: The study found that intracerebroventricular administration of TRV027 can increase aversion to saline and lower blood pressure in a model of salt-sensitive hypertension. Both TRV027 and losartan increased aversion to saline, with a more pronounced effect on highly aversive saline solutions.
Review
Medicine, Research & Experimental
Minela Aida Maranduca, Andreea Clim, Alin Constantin Pinzariu, Cristian Statescu, Radu Andy Sascau, Daniela Maria Tanase, Dragomir Nicolae Serban, Daniel Constantin Branisteanu, Daciana Elena Branisteanu, Bogdan Huzum, Ionela Lacramioara Serban
Summary: Chronic kidney disease (CKD) is a significant public health issue with irreversible loss of functional nephrons. Hypertension and diabetes are the main causes. The excessive activation of the renin angiotensin system leads to systemic and renal effects, resulting in high blood pressure and ultimately CKD. This review provides an overview of the pathophysiological associations between CKD, hypertension, and angiotensin II.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Peripheral Vascular Disease
Madeleine R. Paterson, Kristy L. Jackson, Malathi S. I. Dona, Gabriella E. Farrugia, Bruna Visniauskas, Anna M. D. Watson, Chad Johnson, Minolfa C. Prieto, Roger G. Evans, Fadi J. Charchar, Alexander R. Pinto, Francine Z. Marques, Geoffrey A. Head
Summary: miR-181a is downregulated in the kidneys of hypertensive patients and mice. Deletion of miR-181a/b-1 in mice leads to increased blood pressure and salt sensitivity. Single-nuclei RNA sequencing revealed dysregulation of genes related to immune system, inflammatory response, and nerve development in the kidneys of KO mice.
Article
Neurosciences
Baojian Xue, Jun-Ling Cui, Fang Guo, Terry G. Beltz, Zi-Gang Zhao, Geng-Shen Zhang, Alan Kim Johnson
Summary: Exercise training has a beneficial role in preventing hypertensive response sensitization, by shifting the balance of prohypertensive and antihypertensive pathways in the brain, which leads to reduced central activity driving sympathetic outflow and blood pressure.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Peripheral Vascular Disease
Noha M. Shawky, Carolina Dalmasso, Norma B. Ojeda, Yvonne Zuchowski, Nina Stachenfeld, Barbara T. Alexander, Jane F. Reckelhoff
Summary: Female offspring of hyperandrogenemic female (HAF) rats may be protected from developing hypertension but may be at risk for renal injury.
JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Natalia M. Mathieu, Pablo Nakagawa, Connie C. Grobe, John J. Reho, Daniel T. Brozoski, Ko-Ting Lu, Kelsey K. Wackman, McKenzie L. Ritter, Jeffrey L. Segar, Justin L. Grobe, Curt D. Sigmund
Summary: In salt-sensitive hypertension, ARRB2 may counterbalance the canonical signaling of GPCRs, while ARRB1 has no significant effect.
Article
Cell Biology
Xiaochun Li, Jialong Zhuo
Summary: This study investigates the involvement of intracellular Ang II and its receptors in the uptake of extracellular Ang II by kidney proximal tubules, as well as the effects of intracellular Ang II on the expression of NHE3, Na+/HCO3- cotransporter, and Sglt2 through AT(1a)/MAPK/ERK1/2/NF-kB signaling pathways. The results demonstrate that both extracellular and intracellular Ang II stimulate the expression of these proteins in the proximal tubules.
Article
Pharmacology & Pharmacy
Andre Felipe Rodrigues, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader
Summary: The study found that FVB/N mice without angiotensin peptides do not experience hypotension but regulate blood pressure through compensatory mechanisms. However, these mice also exhibit renal morphological and physiological changes, which may make them a model for drug-resistant hypertension.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Physiology
Lindsey A. Ramirez, Riyaz Mohamed, Terri Marin, Michael W. Brands, Elizabeth Snyder, Jennifer C. Sullivan
Summary: Prenatal, perinatal, and adulthood exposure to chronic intermittent hypoxia (IH) increases blood pressure in rodents. Males exposed to chronic IH have higher blood pressure versus females. Acute perinatal IH enhances early ANG II-induced hypertension in males, independent of nephron loss or decreases in body weight or kidney function.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ernesto L. Schiffrin
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Sofiane Ouerd, Noureddine Idris-Khodja, Michelle Trindade, Nathanne S. Ferreira, Olga Berillo, Suellen C. Coelho, Mario F. Neves, Karin A. Jandeleit-Dahm, Pierre Paradis, Ernesto L. Schiffrin
Summary: Endothelial ET-1 overexpression exacerbates atherosclerosis, perivascular oxidative stress, and inflammation in type 1 diabetes through NOX1.
CARDIOVASCULAR RESEARCH
(2021)
Article
Physiology
Akinori Higaki, Ahmad U. M. Mahmoud, Pierre Paradis, Ernesto L. Schiffrin
Summary: The study developed an automatic artery/vein differentiation and size measurement system using machine learning algorithms. Through model training and image analysis, the method successfully assessed vessel structures effectively. The results showed a strong linear correlation between the measured vessel and lumen sizes and manually determined values, demonstrating the potential utility of the method in evaluating artery sizes for experimental studies.
JOURNAL OF VASCULAR RESEARCH
(2021)
Editorial Material
Peripheral Vascular Disease
Ernesto L. Schiffrin
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Editorial Material
Peripheral Vascular Disease
Ernesto L. Schiffrin
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Review
Peripheral Vascular Disease
Damiano Rizzoni, Carolina De Ciuceis, Piotr Szczepaniak, Pierre Paradis, Ernesto L. Schiffrin, Tomasz J. Guzik
Summary: Low-grade inflammation and oxidative stress are crucial in the development of hypertension and related organ damage. Innate immune cells and adaptive immunity play a role in vascular inflammation, while effector T lymphocytes may promote hypertension and microvascular remodeling. Immune mechanisms contribute to oxidative stress and target organ damage in hypertension.
Editorial Material
Peripheral Vascular Disease
Ernesto L. Schiffrin
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Editorial Material
Peripheral Vascular Disease
Ernesto L. Schiffrin
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Editorial Material
Peripheral Vascular Disease
Ernesto L. Schiffrin
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Medicine, General & Internal
Carol Y. Cheung, Valerie Biousse, Pearse A. Keane, Ernesto L. Schiffrin, Tien Y. Wong
Summary: Hypertensive eye disease refers to eye diseases associated with high blood pressure. It includes various pathological changes, with hypertensive retinopathy being the most well-known. Research has greatly improved our understanding of the epidemiology and clinical implications of hypertensive eye disease. Advances in technology, such as optical coherence tomography angiography and artificial intelligence, have contributed to better assessment and management of hypertension and cardiovascular risk using ocular imaging.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Editorial Material
Peripheral Vascular Disease
Ernesto L. Schiffrin
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Pediatrics
Johanne Kerba, Catherine Demers, Veronique Belanger, Melanie Napartuk, Isabelle Bouchard, Caroline Meloche, Sophia Morel, Nicolas Prud'homme, Isabelle Gelinas, Johanne Higgins, Daniel Curnier, Serge Sultan, Caroline Laverdiere, Daniel Sinnett, Valerie Marcil
Summary: This study aims to assess the needs, barriers and facilitators to healthy lifestyle promotion interventions for adolescents with cancer. The findings suggest that adolescents with cancer need activities adapted to their age, peer support, and support to maintain their education and friendships. Lack of motivation, fatigue, and treatment side effects are reported as barriers to intervention.
Editorial Material
Cardiac & Cardiovascular Systems
Ernesto L. Schiffrin
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ernesto L. Schiffrin, James C. Engert
EUROPEAN HEART JOURNAL
(2023)
Article
Pediatrics
Melanie Napartuk, Veronique Belanger, Isabelle Bouchard, Caroline Meloche, Daniel Curnier, Serge Sultan, Caroline Laverdiere, Daniel Sinnett, Valerie Marcil
Summary: This study examined the changes in diet and anthropometric and cardiometabolic profiles of children and adolescents undergoing cancer treatments after a one-year nutritional intervention. It found that the intervention improved diet quality and adherence, as well as weight, BMI, HDL-C levels, and vitamin D levels.