Article
Biochemistry & Molecular Biology
Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E. Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A. Hannun, Takeshi Nabe, Kazuyuki Kitatani
Summary: Regulation of sphingolipid metabolism has a significant impact on cellular homeostasis and cancer progression. Dysregulation of ceramide-centered metabolism is associated with metastatic potential in ovarian cancer cells. Specifically, the CerS2-C-24:1-ceramide axis, possibly counteracted by neutral ceramidase, plays a key role in limiting cell motility and metastatic potential.
Review
Oncology
Jinfeng Liang, Lin Li, Limei Li, Xiaoying Zhou, Zhe Zhang, Yi Huang, Xue Xiao
Summary: Lipid metabolism reprogramming is a significant metabolic anomaly in cancer, including head and neck cancer. This review examines the dysregulated molecules and pathways of lipid metabolism in head and neck cancer, and discusses their associations with cancer development, treatment, and prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Rebekah J. Nicholson, Marcus G. Pezzolesi, Scott A. Summers
Summary: Diabetic kidney disease (DKD) is a prevalent and progressive comorbidity of diabetes mellitus that increases the risk of renal failure. Research suggests that bioactive ceramides may serve as a potential therapeutic target for DKD, as modulation of renal ceramide levels could improve kidney function and ameliorate DKD pathology. Studies have shown that circulating sphingolipid profiles can distinguish DKD patients from diabetic controls, highlighting the potential of ceramide as a central and therapeutically tractable lipid mediator of DKD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Antia Custodia, Marta Aramburu-Nunez, Clara Correa-Paz, Adrian Posado-Fernandez, Ana Gomez-Larrauri, Jose Castillo, Antonio Gomez-Munoz, Tomas Sobrino, Alberto Ouro
Summary: This article summarizes the role of ceramide in cellular processes and highlights its importance in neurodegenerative diseases, particularly in Parkinson's disease.
Article
Endocrinology & Metabolism
Rebekah J. Nicholson, Annelise M. Poss, J. Alan Maschek, James E. Cox, Paul N. Hopkins, Steven C. Hunt, Mary C. Playdon, William L. Holland, Scott A. Summers
Summary: The rs267738 SNP in the CERS2 gene leads to a partial loss-of-function of the enzyme, worsening metabolic parameters in knock-in mice. However, it did not significantly affect serum sphingolipid profiles in subjects from the Utah Coronary Artery Disease Study.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Jiyoon L. Kim, Beatriz Mestre, Sun-Hye Shin, Anthony H. Futerman
Summary: Sphingolipids are a crucial family of lipids in cell function and survival, and recent research in this field has been led by a closely-knit group of researchers, including the late Dr. Lina Obeid. Dr. Obeid's valuable contributions to sphingolipid research centered on the "many-worlds" view of ceramides and the role of ceramide synthases (CerS) in the sphingolipid metabolic pathway.
CELLULAR SIGNALLING
(2021)
Review
Oncology
Jaewang Lee, Jong-Lyel Roh
Summary: Ferroptosis is a newly regulated cell death induced by iron-mediated lipid peroxidation. Altered cancer metabolism contributes to cancer proliferation, metastasis, and treatment resistance. Changes in metabolism increase the sensitivity of cancer cells to lipid peroxidation toxicity and can be targeted for cancer treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Jaewang Lee, Jong-Lyel Roh
Summary: Most head and neck cancers originate from mucosal epithelial cells. The loss of epithelial traits by the epithelial-mesenchymal transition may render cells vulnerable to ferroptosis, a novel non-apoptotic regulated cell death, by the iron-dependent accumulation of excessive lipid peroxidation. This article discusses the potential effect of ferroptosis induction as a novel treatment for resilient head and neck cancers.
Review
Oncology
Xingkai Liu, Ping Zhang, Jing Xu, Guoyue Lv, Yan Li
Summary: Bioactive lipid molecules play important roles in linking obesity/metabolic syndrome and cancers. Controlling lipid metabolism can be a potential strategy for cancer prevention and therapy. Comprehensive understanding of the regulatory role of lipid metabolism in cellular entities and their tumor microenvironment will provide a new direction for further studies and development of novel anti-cancer strategies.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Xiangwan Miao, Beilei Wang, Kaili Chen, Rui Ding, Jichang Wu, Yi Pan, Peilin Ji, Bin Ye, Mingliang Xiang
Summary: The role of lipid metabolism reprogramming in HNSCCs is not yet fully understood. This review summarizes its crucial cellular signaling roles in tumorigenicity and malignancy, and discusses the differences between different regions of HNSCCs caused by anatomical heterogeneity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ping Lu, Shai White-Gilbertson, Gyda Beeson, Craig Beeson, Besim Ogretmen, James Norris, Christina Voelkel-Johnson
Summary: The study reveals differences in sphingolipid metabolism between non-polyploid and polyploid cancer cells, showing that CerS6 in polyploid cells enhances the ability of the tumor suppressor p53 to inhibit progeny formation. Modulation of C-16-ceramide can prevent polyploid giant cancer cells from generating offspring, and targeting sphingolipid metabolism pathway holds potential for clinical intervention.
Article
Biochemistry & Molecular Biology
Mazen Aseeri, Jose Luis Abad, Antonio Delgado, Gemma Fabrias, Gemma Triola, Josefina Casas
Summary: Ceramide plays a crucial role in regulating cellular senescence and apoptosis. Acid ceramidase (AC) reduces Ceramide levels, which is abnormally expressed in various cancers. However, the lack of suitable screening formats has hindered AC inhibitor discovery. In this study, a fluorogenic assay was adapted to a 384-well plate format, overcoming this limitation. The optimized platform successfully screened a library of 4100 compounds and identified several hits with potency ranges of 2-25 μM, belonging to different chemical classes. These inhibitors showed selectivity for neutral ceramidase and retained activity in cells, serving as a basis for further chemical optimization.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Ana Gomez-Larrauri, Alberto Ouro, Miguel Trueba, Antonio Gomez-Munoz
Summary: C1P is a bioactive sphingolipid that plays key roles in cellular functions and inflammation-associated pathologies. It promotes cell growth and survival through various signaling pathways, and has shown potential as an anti-inflammatory agent in lung inflammation.
CELLULAR SIGNALLING
(2021)
Review
Oncology
Megan Sheridan, Besim Ogretmen
Summary: Sphingolipids are membrane-associated lipids that play crucial roles in regulating cell functions such as proliferation, migration, senescence, and death. In cancer cells, sphingolipids are involved in pathways relevant to cancer therapy, including invasion, metastasis, apoptosis, and lethal mitophagy. Notable sphingolipids like ceramide and sphingosine-1 phosphate have contrasting effects on cell survival and chemotherapeutic resistance, with ceramide inducing death and lethal mitophagy, and sphingosine-1 phosphate promoting survival. These lipids are characterized by a long-chain sphingosine backbone linked to a fatty acyl chain with variable length, and alterations in ceramide synthases and sphingolipid regulation of mitophagy have important implications for cancer therapy.
Article
Biochemistry & Molecular Biology
Timon Eckes, Sandra Trautmann, Sonja Djudjaj, Sandra Beyer, Sammy Patyna, Stephanie Schwalm, Stefan Gauer, Dominique Thomas, Liliana Schaefer, Peter Boor, Alexander Koch, Josef Pfeilschifter
Summary: The study found that very long-chain ceramides were consistently downregulated in fibrotic kidney samples from human and mouse, correlated with the upregulation of fibrotic markers. These results support the use of murine models to understand the role of ceramides in human kidney diseases and suggest the potential manipulation of ceramide metabolism to prevent fibrosis progression, as well as the use of ceramides as potential biomarkers for chronic kidney disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Oncology
Thomas H. Beckham, Dana L. Casey, Michael P. LaQuaglia, Brian H. Kushner, Shakeel Modak, Suzanne L. Wolden
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Article
Oncology
Thomas H. Beckham, Ping Lu, Joseph C. Cheng, Dan Zhao, Lorianne S. Turner, Xiaoyi Zhang, Stanley Hoffman, Kent E. Armeson, Angen Liu, Tucker Marrison, Yusuf A. Hannun, Xiang Liu
INTERNATIONAL JOURNAL OF CANCER
(2012)
Article
Medicine, Research & Experimental
Joseph C. Cheng, Aiping Bai, Thomas H. Beckham, S. Tucker Marrison, Caroline L. Yount, Katherine Young, Ping Lu, Anne M. Bartlett, Bill X. Wu, Barry J. Keane, Kent E. Armeson, David T. Marshall, Thomas E. Keane, Michael T. Smith, E. Ellen Jones, Richard R. Drake, Alicja Bielawska, James S. Norris, Xiang Liu
JOURNAL OF CLINICAL INVESTIGATION
(2013)
Article
Multidisciplinary Sciences
Thomas H. Beckham, Joseph C. Cheng, Ping Lu, S. Tucker Marrison, James S. Norris, Xiang Liu
Article
Oncology
L. S. Turner, J. C. Cheng, T. H. Beckham, T. E. Keane, J. S. Norris, X. Liu
PROSTATE CANCER AND PROSTATIC DISEASES
(2011)
Article
Endocrinology & Metabolism
Thomas H. Beckham, Paul B. Romesser, Andries H. Groen, Christopher Sabol, Ashok R. Shaha, Mona Sabra, Thomas Brinkman, Daniel Spielsinger, Sean McBride, C. Jillian Tsai, Nadeem Riaz, R. Michael Tuttle, James A. Fagin, Eric J. Sherman, Richard J. Wong, Nancy Y. Lee
Article
Oncology
T. H. Beckham, J. C. Cheng, P. Lu, Y. Shao, D. Troyer, R. Lance, S. T. Marrison, J. S. Norris, X. Liu
Review
Otorhinolaryngology
Thomas H. Beckham, Jonathan Leeman, Chiaojung Jillian Tsai, Nadeem Riaz, Eric Sherman, Bhuvanesh Singh, Nancy Lee, Sean McBride, Daniel S. Higginson
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Editorial Material
Oncology
Thomas H. Beckham, Brandon S. Imber, Charles B. Simone
ANNALS OF TRANSLATIONAL MEDICINE
(2019)
Article
Oncology
Thomas H. Beckham, Jonathan E. Leeman, Peng Xie, Xiaolin Li, Debra A. Goldman, Zhigang Zhang, Eric Sherman, Sean McBride, Nadeem Riaz, Nancy Lee, C. Jillian Tsai
BRITISH JOURNAL OF CANCER
(2019)
Article
Oncology
Thomas H. Beckham, Christian Barney, Erin Healy, Adam R. Wolfe, Andrew Branstetter, Alexander Yaney, Nadeem Riaz, Sean M. McBride, C. Jillian Tsai, Julie Kang, Yao Yu, Linda Chen, Eric Sherman, Lara Dunn, David G. Pfister, Jeremy Tan, Robert Rupert, Marcelo Bonomi, Zhigang Zhang, Stephanie M. Lobaugh, John C. Grecula, Darrion L. Mitchell, Jessica L. Wobb, Eric D. Miller, Dukagjin M. Blakaj, Virginia M. Diavolitsis, Nancy Lee, Aashish D. Bhatt
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Andries H. Groen, Thomas H. Beckham, Thera P. Links, Debra A. Goldman, Eric J. Sherman, Michael M. Tuttle, Hendrik P. Bijl, Richard J. Wong, John Th. M. Plukker, Nancy Y. Lee, Andries H. Groen, John Th. M. Plukker, Thomas H. Beckham, Nancy Y. Lee, Nadeem Riaz, Chiaojung J. Tsai, Yao Yu, Thera P. Links, Debra A. Goldman, Zhigang Zhang, Eric J. Sherman, Michael M. Tuttle, Ashok R. Shaha, Richard J. Wong, Hendrik P. Bijl
JOURNAL OF SURGICAL ONCOLOGY
(2020)
Article
Oncology
Thomas H. Beckham, Joanna C. Yang, Karen W. Chau, Ariela Noy, Joachim Yahalom
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2020)
Article
Oncology
Kelly P. Orwat, Thomas H. Beckham, Samuel Lewis Cooper, Michael S. Ashenafi, Michael Bret Anderson, Marcelo Guimaraes, Ricardo Yamada, David T. Marshall
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2017)
Article
Pharmacology & Pharmacy
Thomas H. Beckham, Ping Lu, Elizabeth E. Jones, Tucker Marrison, Clayton S. Lewis, Joseph C. Cheng, Venkat K. Ramshesh, Gyda Beeson, Craig C. Beeson, Richard R. Drake, Alicja Bielawska, Jacek Bielawski, Zdzislaw M. Szulc, Besim Ogretmen, James S. Norris, Xiang Liu
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2013)