F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity

Survival and Death Strategies in Glioma Cells: Autophagy, Senescence and Apoptosis Triggered by a Single Type of Temozolomide-Induced DNA Damage

(2013) Anna V. Knizhnik et al.   PLoS One

Elacytarabine: lipid vector technology under investigation in acute myeloid leukemia

(2013) Niamh Keane et al.   Expert Review of Hematology

Autophagic activation potentiates the antiproliferative effects of tyrosine kinase inhibitors in medullary thyroid cancer

(2012) Chi-Iou Lin et al.   SURGERY

Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II

(2011) Caroline Ballot et al.   APOPTOSIS

Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II

(2011) Viviane Brel et al.   BIOCHEMICAL PHARMACOLOGY

Interactions between the Etoposide Derivative F14512 and Human Type II Topoisomerases: Implications for the C4 Spermine Moiety in Promoting Enzyme-Mediated DNA Cleavage

(2011) Amanda C. Gentry et al.   BIOCHEMISTRY

Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126

(2011) Auke D. Adema et al.   INVESTIGATIONAL NEW DRUGS

An Integrated Drosophila Model System Reveals Unique Properties for F14512, a Novel Polyamine-Containing Anticancer Drug That Targets Topoisomerase II

(2011) Sonia Chelouah et al.   PLoS One

Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo

(2010) Caroline D. Scatena et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment

(2010) J.-P. Annereau et al.   LEUKEMIA RESEARCH

AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo

(2009) A. Oke et al.   CANCER RESEARCH

Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system

(2009) Anna Kruczynski et al.   INVESTIGATIONAL NEW DRUGS

F14512, a Potent Antitumor Agent Targeting Topoisomerase II Vectored into Cancer Cells via the Polyamine Transport System

(2008) J.-M. Barret et al.   CANCER RESEARCH

Cooperating gene mutations in acute myeloid leukemia: a review of the literature

(2008) A Renneville et al.   LEUKEMIA