Article
Cell Biology
Julian Kanne, Michelle Hussong, Joerg Isensee, Alvaro Munoz-Lopez, Jan Wolffgramm, Felix Hess, Christina Grimm, Sergey Bessonov, Lydia Meder, Jie Wang, H. Christian Reinhardt, Margarete Odenthal, Tim Hucho, Reinhard Buettner, Daniel Summerer, Michal R. Schweiger
Summary: Non-coding RNA from pericentromeric satellite repeats, specifically SatIII, plays a crucial role in lung cancer drug resistance, possibly through mechanisms related to genome stability, cancer therapy, and endogenous stress response processes.
CELL DEATH & DISEASE
(2021)
Article
Plant Sciences
Chengyun Wu, Xiaoqing Wang, Weibo Zhen, Yaqing Nie, Yan Li, Penglai Yuan, Qiaoqiao Liu, Siyi Guo, Zhenguo Shen, Binglian Zheng, Zhubing Hu
Summary: The degradation of lariat intronic RNAs (lariRNAs) modulated by SICKLE (SIC) is essential for lateral root development in Arabidopsis. SIC interacts with DBR1 and facilitates its nuclear accumulation, leading to lariRNA decay and fine-tuning of miRNA biogenesis, thereby regulating lateral root development.
Article
Biochemistry & Molecular Biology
Warusavithana Gunawardena Manori De Silva, Bianca Yuko McCarthy, Jeremy Han, Chen Yang, Andrew J. A. Holland, Harvey Stern, Katie Marie Dixon, Edith Kai Yan Tang, Robert Charles Tuckey, Mark Stephen Rybchyn, Rebecca Sara Mason
Summary: In this study, it was found that the over-irradiation metabolite 24(OH)L-3 provided photoprotection against UV-induced DNA damage similar to that of 1,25(OH)(2)D-3. The mechanisms involved increased energy availability and DNA repair, as well as decreased reactive oxygen species.
Article
Pharmacology & Pharmacy
Christian Bailly
Summary: The bacterial thiopeptide thiostrepton (TS) is used as a veterinary medicine to treat bacterial infections and also has antimalarial and anticancer effects. TS targets both infectious pathogens and host cells and exerts its effects through multiple mechanisms. However, formulation difficulties hinder the pharmaceutical development of this drug.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gerard Vergoten, Christian Bailly
Summary: Panduratin A (Pa-A), isolated from fingerroots, has shown antiviral activity against SARS-CoV-2. Molecular docking revealed potential protease inhibition properties of Pa-A and its derivatives, offering insights for designing new molecules that interact with M-pro.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Oncology
Xavier Thuru, Romain Magnez, Hassiba El-Bouazzati, Gerard Vergoten, Bruno Quesnel, Christian Bailly
Summary: Repositioning approved drugs that modulate the PD-1/PD-L1 immune checkpoint can improve cancer immunotherapy. These drugs have the potential to bind to PD-L1 or suppress its expression and function, offering new possibilities for combination therapies with PD-1 targeted biotherapeutics.
Article
Parasitology
Christian Bailly
Summary: Neglected tropical parasitic diseases (NTD) are prevalent and require cost-effective treatments. The TIM-3/galectin-9 checkpoint has been shown to play a key role in antiparasitic immunity. This review discusses the role of this checkpoint in seven major NTD and evaluates the potential use of anti-TIM-3 antibodies as a therapeutic approach. The use of anti-TIM-3 antibodies has shown promising results in cases of leishmaniasis, malaria, and schistosomiasis, but has been less effective in echinococcosis and Chagas disease.
Article
Plant Sciences
Gerard Vergoten, Christian Bailly
Summary: Cryptoconcatones A-L is a series of 12 dihydropyrone derivatives isolated from the evergreen tree Cryptocarya concinna Hance, with potential antiproliferative activity against cancer cells. In this study, the interaction of these compounds with tubulin dimers was investigated using molecular docking. Two compounds, cryptoconcatones F and L, showed stronger binding capacity to alpha-tubulin than pironetin, a known microtubule polymerization inhibitor. The study contributes to the understanding of the mechanism of action of cryptoconcatones and may aid in the design of analogues targeting the pironetin site of alpha-tubulin.
Review
Integrative & Complementary Medicine
Christian Bailly, Cheng Xiang, Ji-Hong Zhang
Summary: Qingyangshen, also known as the roots of Cynanchum otophyllum, is a traditional medicine used in Yunnan province, China. It has various applications in treating epilepsy, rheumatism, and other inflammatory diseases. It is also used in cosmetic and food supplements, as well as hair loss reduction preparations.
WORLD JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
Article
Biology
Gerard Vergoten, Christian Bailly
Summary: This study investigates the influence of protein N-glycosylation on drug-protein binding and finds that N-glycosylation can further stabilize drug-protein complexes. The glycan can interact directly with the drug to consolidate drug binding and protect the stability of drug-protein interactions. The findings have important implications for understanding the impact of N-glycosylation on drug-receptor interactions.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Romain Regnault, Frederique Klupsch, Hassiba El-Bouazzati, Romain Magnez, Rapha Le Biannic, Natascha Leleu-Chavain, Hania Ahouari, Herve Vezin, Regis Millet, Jean-Francois Goossens, Xavier Thuru, Christian Bailly
Summary: Compounds 2-5 were designed and characterized with improved anti-PD-L1 activity, with compound 5 emerging as a potent checkpoint inhibitor. It binds to PD-L1, induces its dimerization, blocks PD-1/PD-L1 signaling, and reactivates cell proliferation. Additionally, compound 5 maintains significant antioxidant activity.
Article
Biochemistry & Molecular Biology
Christian Bailly, Gerard Vergoten
Summary: The antitumor drug topotecan inhibits topoisomerase I and triggers DNA breaks in cancer cells. It can also bind to the ribosomal protein L15 and induce antitumor immune activation independently of topoisomerase I. This study provides insights into the binding sites and molecular interactions between camptothecins and ribosomal proteins, which can guide the design of anticancer agents targeting L11 and L15.
Review
Oncology
Christian Bailly, Xavier Thuru
Summary: Tetraspanin CD81 plays important roles in cell-cell interactions and cellular trafficking. It serves as a co-receptor for various viruses and has implications in cancer cell proliferation, mobility, and metastasis. CD81-protein interactions can be targeted with molecules, such as monoclonal antibodies and natural/synthetic compounds, which have potential antiviral and anticancer properties.
Review
Plant Sciences
Christian Bailly
Summary: The genus Ruta in the family Rutaceae includes about 40 species, including well-known plants such as common rue and fringed rue, as well as lesser-known species like narrow-leaved fringed rue. The narrow-leaved fringed rue, originating from the Mediterranean region, is well-distributed in Southeast Asia and is used in some countries to treat liver diseases and cancer. Extracts of this plant have antifungal, antiviral, and antiparasitic effects.
Review
Biology
Christian Bailly
Summary: This analysis retraces the discovery of a series of sesquiterpenes, plagiochilins A-W, isolated from various liverwort plants. While these compounds have been little studied from a pharmacological perspective, plagiochilins A and C have exhibited significant antiproliferative activities against cultured cancer cells. Plagiochilin A and its derivatives hold potential for further research and the design of novel anticancer drugs.
Article
Biochemistry & Molecular Biology
Christian Bailly
Summary: The roots of Euphorbia ebracteolata Hayata have long been used in traditional Chinese medicine for the treatment of various diseases. Several bioactive compounds, including diterpenoids, have been isolated from this plant, some of which have anti-inflammatory and anticancer properties. The origin, structural diversity, and properties of these little-known natural products are discussed.
Article
Plant Sciences
Christian Bailly
Summary: Chai-Ling-Tang, also known as Siryung-tang and Sairei-To, is a complex polyherbal formulation used for over 2000 years in East Asia. It is traditionally used to treat Shaoyang syndrome and regulate body fluid homeostasis. It combines two traditional Chinese herbal medicine prescriptions and has diverse therapeutic uses, including autoimmune diseases, inflammatory disorders, and cancers.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Medicinal
Christian Bailly
Summary: Fungi produce a large variety of isoindolinone derivatives as secondary metabolites, which exhibit diverse pharmacological activities, including anti-inflammatory, antiviral, and anticancer properties. These fungal products can be utilized for their medicinal properties and serve as a basis for designing analogues targeting different enzymes or pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS
(2023)