期刊
JOURNAL OF BONE AND MINERAL METABOLISM
卷 28, 期 3, 页码 244-250出版社
SPRINGER JAPAN KK
DOI: 10.1007/s00774-009-0154-7
关键词
Multiple myeloma; Bone microenvironment; Bisphosphonates; Osteoclast; Cytokines
Multiple myeloma (MM) is a plasma cell malignancy characterized by the frequent development of osteolytic lesions, osteopenia, pathological fractures, and/or severe bone pain. In the past few years several potential factors involved in this process have been identified and, with the increased knowledge of the signaling pathways involved in the regulation of normal osteoblast and osteoclast function, have provided us with a better understanding of the contributions of the marrow microenvironment to MM bone disease. These studies have identified several potential novel targets for treating MM bone disease in addition to the current standard treatment of bisphosphonates. In this article, we discuss several potential targets for treating MM bone disease as well as novel therapies that are in clinical trials for these patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据