Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

(2011) J. Tatarek et al.   BLOOD

Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies

(2011) L. M. Treanor et al.   BLOOD

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia

(2011) R. M. Demarest et al.   BLOOD

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

(2011) Emmanuelle Clappier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch signaling in mammalian hematopoietic stem cells

(2011) K V Pajcini et al.   LEUKEMIA

Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

(2011) B Gerby et al.   LEUKEMIA

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope

(2011) Jessica S Blackburn et al.   Nature Protocols

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

(2010) R. Jeannet et al.   BLOOD

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia

(2010) A. C. H. Smith et al.   BLOOD

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

(2010) Hui Feng et al.   CANCER CELL

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes

(2010) M. Tremblay et al.   GENES & DEVELOPMENT

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

(2010) Agnieszka A. Wendorff et al.   IMMUNITY

The TLX1 oncogene drives aneuploidy in T cell transformation

(2010) Kim De Keersmaecker et al.   NATURE MEDICINE

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

(2010) M. P. McCormack et al.   SCIENCE

Notch ligands potentiate IL-7-driven proliferation and survival of human thymocyte precursors

(2009) Maymouna Magri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

(2009) Monique L Den Boer et al.   LANCET ONCOLOGY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia

(2008) Pieter Van Vlierberghe et al.   BRITISH JOURNAL OF HAEMATOLOGY

Utilization of Pathway Signatures to Reveal Distinct Types of B Lymphoma in the E -myc Model and Human Diffuse Large B-Cell Lymphoma

(2008) S. Mori et al.   CANCER RESEARCH

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

(2008) Paul S. Knoepfler   Cell Stem Cell

Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

(2008) Xiaoyu Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish

(2008) D M Langenau et al.   ONCOGENE