Article
Biochemistry & Molecular Biology
Dilipkumar Pal, In-ho Song, Shrikant Dashrath Warkad, Keum-soo Song, Gyu Seong Yeom, Supriyo Saha, Pramod B. Shinde, Satish Balasaheb Nimse
Summary: This review presents the research advances on compounds containing indazole scaffolds as microtubule targeting agents based on articles published in the last two decades. Several compounds have shown potent microtubule inhibition and anticancer activity, with some of them having the lowest IC50 values observed in cell line studies.
BIOORGANIC CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Suxing Jin, Yan Guo, Zijian Guo, Xiaoyong Wang
Summary: Monofunctional platinum(II) complexes are a class of non-traditional anticancer agents hopeful to overcome the defects of current platinum drugs, with designs aiming to visualize cellular distribution, reduce side effects, improve tumor selectivity, or inhibit cancer cells through non-DNA targets.
Article
Chemistry, Inorganic & Nuclear
Johannes Karges, Kai Xiong, Olivier Blacque, Hui Chao, Gilles Gasser
Summary: The study found that copper (II) polypyridine complexes have significant cytotoxic effects on human adenocarcinomic alveolar basal epithelial cells, and are equally effective against cisplatin-resistant cells, potentially serving as a treatment option for drug-resistant tumors.
INORGANICA CHIMICA ACTA
(2021)
Review
Pharmacology & Pharmacy
Tugce Boztepe, Guillermo R. Castro, Ignacio E. Leon
Summary: Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Qianqian Li, Weiwei Zhang
Summary: Ubiquitination plays a critical role in signal pathways by monitoring protein stability, subcellular localization, and activity. Dysfunction in this process can lead to severe diseases, including malignant cancers. The development of drugs targeting ubiquitination-related factors has become a hot topic in research for improved therapy of human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jiating Qi, Zhuqing Ouyang
Summary: This article summarizes the targeted therapies for cyclin-dependent kinase 4/6 (CDK4/6), including CRISPR, siRNA, and drug inhibition. It highlights the mechanisms of small molecular inhibitors and drug resistance, and describes strategies to combat resistance.
Review
Biotechnology & Applied Microbiology
Tingting Hu, Zhou Qin, Chao Shen, Han-Lin Gong, Zhi-Yao He
Summary: Mitochondria play crucial roles in cancer cells, and precise delivery of anticancer agents to mitochondria can be a novel strategy for enhanced cancer treatment. Overcoming the challenge of mitochondrial negative potential preventing molecules from reaching them, advancements in nanosystems such as liposomes, nanoparticles, and nanomicelles provide hope for targeted drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shuhang Wang, Kun Chen, Yale Jiang, Guo Zhao, Caie Wang, Hong Fang, Qiyu Tang, Chao Sun, Liang Zhang, Haiyang Wu, Li-Feng Zhang, Ning Li
Summary: Natural killer (NK) cell therapy is emerging as a promising cancer treatment that utilizes innate cytotoxic lymphocytes with germline-encoded receptors to kill cancer cells, virus-infected cells, and other stressed cells. NK cells have the advantage of being safe for allogeneic applications and can be used as off-the-shelf cells, overcoming the limitations of autologous cell therapy. However, NK cells have a shorter in vivo persistence compared to T cells, but they have a reservoir of innate immune receptors and can utilize antibody guidance for target recognition.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Medicinal
Ajay Pal, James F. Curtin, Gemma K. Kinsella
Summary: The study generated a homology model of GPR120S and identified potential anti-colorectal cancer compounds using DBVS, SAR, and in vitro screening. Compound 1 showed a 90% inhibitory effect on cell growth in GPR120-positive SW480 cells with micromolar affinities. SAR analysis of compound 1 led to the discovery of a more active compound from the SPECS database.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Plant Sciences
Cassandra L. Roberge, Rebecca T. Miceli, Lillian R. Murphy, David M. Kingsley, Richard A. Gross, David T. Corr
Summary: Sophorolipids, derived from nonpathogenic yeasts, have potential efficacy in anticancer applications. They can be synthesized cost-effectively, making them promising alternatives to traditional chemotherapeutics. This study screened two sophorolipids and a clinically-used chemotherapeutic on breast cancer models in various dimensions. The findings demonstrate the importance of 3D tumor models in assessing drug response and suggest that one of the sophorolipids could be comparable in toxicity to the chemotherapeutic control.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Qiyuan Zhou, Shu Chen, Zoufeng Xu, Gongyuan Liu, Shuyuan Zhang, Zhigang Wang, Man-Kit Tse, Shek-Man Yiu, Guangyu Zhu
Summary: This study reports the synthesis of Pt-IV complexes bearing axial pyridines through ligand exchange reactions. It was discovered that these axial pyridines can be quickly released after reduction, indicating their potential as axial leaving groups. Two multitargeted Pt-IV prodrugs containing bioactive pyridinyl ligands, a PARP inhibitor and an EGFR tyrosine kinase inhibitor, were successfully obtained using this method. These conjugates show great potential for overcoming drug resistance, with the latter inhibiting the growth of Pt-resistant tumor in vivo. This research expands the synthetic methods for Pt-IV prodrugs and increases the range of bioactive axial ligands that can be conjugated to a Pt-IV center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Immunology
Rainer Knoll, Lorenzo Bonaguro, Jessica C. dos Santos, Stefanie Warnat-Herresthal, Maartje C. P. Jacobs-Cleophas, Edda Bluemel, Nico Reusch, Arik Horne, Miriam Herbert, Melanie Nuesch-Germano, Twan Otten, Wouter A. Van der Heijden, Lisa Van de Wijer, Alex K. Shalek, Kristian Handler, Matthias Becker, Marc D. Beyer, Mihai G. Netea, Leo A. B. Joosten, Andre J. A. M. Van der Ven, Joachim L. Schultze, Anna C. Aschenbrenner
Summary: The study found that immune cells of PLHIV have altered transcriptomes, and single-cell RNA sequencing can identify drug candidates to reverse this state. These scientific findings and technological advancements provide the basis for further large-scale cohort studies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jaewan Jeon, Sungmin Lee, Hyunwoo Kim, Hyunkoo Kang, HyeSook Youn, Sunmi Jo, BuHyun Youn, Hae Yu Kim
Summary: This article discusses the anticancer effects and advantages of platinum-based drugs used in the treatment of brain tumors, and summarizes their clinical application cases and limitations. To overcome these obstacles, a novel approach to enhance the effectiveness of platinum-based drugs is emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jovana J. Ajdukovic, Dimitar S. Jakimov, Lucie Rarova, Miroslav Strnad, Yaraslau U. Dzichenka, Sergey Usanov, Dusan D. Skoric, Suzana S. Jovanovic-Santa, Marija N. Sakac
Summary: This study synthesized novel O-alkylated oxyimino androst-4-ene derivatives with potential anticancer properties, showing strong cytotoxic activity against various human cancer cell lines and inhibiting angiogenesis and lung cancer cell proliferation in vitro. Certain compounds selectively bound to active sites of human steroid hydroxylases, suggesting a potential for developing novel enzyme activity modulators.
Article
Biotechnology & Applied Microbiology
Cong Hua, Yi Zhang, Yuanhao Liu
Summary: The research explores the potential of polymer micelles as carriers for chemotherapeutic agents, demonstrating their effectiveness in suppressing tumor growth and reducing systemic toxicity. By manipulating the chemical and physical properties of amphiphilic Y-shaped polypeptides, the self-assembly performance of micelles and the controlled release of drugs can be significantly regulated.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
