Review
Biotechnology & Applied Microbiology
Neha Kaushik, Shweta B. Borkar, Sondavid K. Nandanwar, Pritam Kumar Panda, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Nanocarriers (NCs) have attracted significant attention for their structural ability, good biocompatibility, and biodegradability. The development of NCs with stimuli-responsive properties has become a hot topic among scientists. These NCs can deliver drugs to tumors by regulating their pH, temperature, and enzyme responsiveness, thereby improving the accuracy of drug delivery and minimizing side effects. Material carriers for chemotherapeutic medicines are discussed in this review, with a focus on their structural properties and targeting methods that enhance therapeutic efficacy and trigger metabolic pathways. Overall, the development of NCs that respond to endogenous and exogenous stimuli in tumor regions and the understanding of their mechanisms have great potential for advancing tumor therapy and precision diagnosis in the future.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Weiwei Zhao, Hua Wang, Haimang Wang, Ying Han, Zhibo Zheng, Xudong Liu, Bin Feng, Hongyu Zhang
Summary: The visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles and beta-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) can effectively induce drug release after passing through the dermal tissue and enhance lubrication, which is beneficial for the treatment of osteoarthritis.
Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.
Review
Chemistry, Multidisciplinary
Qi Jiang, Shufang Zhang
Summary: Osteoarthritis (OA) is a common age-related degenerative disease that poses economic and societal burdens, especially with the increasing aging population. Stimulus-responsive nanoplatforms offer improved therapeutic strategies for OA, with potential benefits such as enhanced control, longer retention time, higher loading rates, and increased sensitivity. This review summarizes the advanced application of stimulus-responsive drug delivery nanoplatforms, categorized by endogenous and exogenous stimuli, and discusses the opportunities, restrictions, and limitations of these systems.
Article
Chemistry, Multidisciplinary
Yanfang Wang, Pengbo Chen, Wei Liu, Xiangqian Wei, Juan Zhang, Xinwei Wei, Yun Liu, Luxuan Rao, Shiming Zhang, Jicheng Yu, Xiao Ye, Jinqiang Wang, Zhen Gu
Summary: Researchers have developed a novel insulin nanocarrier system that can effectively and safely control blood glucose levels in type 1 diabetes patients for an extended period of time.
Article
Polymer Science
Yanggui Wu, Huiying Wang, Qianqian Liu, Frederic Lortie, Julien Bernard, Wolfgang H. Binder, Senbin Chen, Jintao Zhu
Summary: This study successfully constructs polymer micelles loaded with chemotherapy drugs and photothermal agents for combined chemo-photothermal therapies, by integrating biomedical applications with supramolecular chemistry.
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Chemistry, Multidisciplinary
Rangrang Fan, Caili Chen, Huan Hou, Di Chuan, Min Mu, Zhiyong Liu, Ruichao Liang, Gang Guo, Jianguo Xu
Summary: The development of folic acid functionalized polydopamine nanoparticles for dual delivery of doxorubicin and epigallocatechin-3-gallate has shown promising results in enhancing cellular uptake and anti-tumor efficacy with the assistance of near-infrared light. In vivo studies demonstrate improved drug accumulation, penetration, and retention in tumors, leading to significant suppression of tumor growth and improved survival rates in breast cancer-bearing mice. These nanoparticles have the potential to serve as an effective nanoscale vector for enhanced cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yun Liu, Yanfang Wang, Yuejun Yao, Juan Zhang, Wei Liu, Kangfan Ji, Xinwei Wei, Yuanwu Wang, Xiangsheng Liu, Shiming Zhang, Jinqiang Wang, Zhen Gu
Summary: Lipid nanoparticle-based drug delivery systems have a significant impact on nucleic acid-based therapy and vaccination. We designed phenylboronic acid-based quaternary amine-type cationic lipids that can self-assemble into spherical lipid nanoparticles. Mixing insulin with the lipid nanoparticles immediately forms a heterostructured insulin complex, and in a hyperglycemia-relevant glucose solution, the lipid nanoparticles gradually become less positively charged, leading to insulin release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Xi-Xi Chen, Mei-Jia Hou, Wen-Xin Wang, Min Tan, Zhi-Ke Tan, Guo-Jiang Mao, Bin Yang, Yongfei Li, Chun-Yan Li
Summary: This study developed MOF-based nanoparticles that can achieve controlled drug delivery and synergistic therapy. These nanoparticles are destructed in cancer cells, releasing fluorescent substances and achieving drug delivery and starvation therapy, with excellent anti-tumor efficiency.
Review
Polymer Science
Dong-Jin Lim, Hong-Jun Kim
Summary: This review provides an overview of advanced fabrication techniques for microneedles and discusses various drug coating and drug elution strategies. It also explores the potential of microneedle technologies in improving the clinical efficacy of treating skin diseases.
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Article
Engineering, Biomedical
Lifo Ruan, Jun Chen, Chuanchao Du, Huiru Lu, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Wenchu Lin, Zhifang Chai, Guangjun Nie, Yi Hu
Summary: The use of mitochondrial temperature-responsive drug delivery system can prevent drug efflux, facilitate drug accumulation and mitochondrial targeting in drug-resistant tumors. This technology enhances drug toxicity and reverses drug resistance, representing a significant advancement in combating cancer drug resistance.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Physical
Krystal A. A. Hughes, Bishal Misra, Maryam Maghareh, Sharan Bobbala
Summary: Drug delivery has seen significant progress in the past decade, particularly in the development of targeted therapies and intracellular delivery. However, the imprecise and non-targeted release profiles of intracellular drug delivery systems pose limitations. Stimuli-responsive soft nanoparticles, containing organic materials such as lipids and polymers, offer a solution to this problem. The choice of biomaterial is crucial for these soft nanoparticles to respond to internal or external stimuli, while maintaining integrity in non-targeted physiological conditions and releasing drugs in specific intracellular environments.
Article
Chemistry, Multidisciplinary
Yongkui Chen, Jikuan Qiu, Xia-Guang Zhang, Huiyong Wang, Wenhui Yao, Zhiyong Li, Qingchun Xia, Guangshan Zhu, Jianji Wang
Summary: Covalent organic frameworks (COFs) have attracted significant interest as proton-exchange membranes, chemical sensors, and electronic devices. The synthesis of a light/heat switchable COF-HNU9, capable of reversible photoisomerization and high proton conductivity, has been achieved through the incorporation of a donor-acceptor Stenhouse adduct (DASA) within the COF structure. The COF-HNU9 showed a substantial increase in proton conductivity under visible light irradiation at high humidity, demonstrating promising prospects for stimuli-responsive COFs.