Review
Biochemistry & Molecular Biology
Cha Yee Kuen, Mas Jaffri Masarudin
Summary: Lung cancer is one of the most common and lethal cancer diseases worldwide. Chitosan nanoparticle (CNP) systems, as a nano-particulate delivery vehicle, have emerged as a promising approach for lung cancer treatment. This review discusses the advantages, challenges, opportunities, drug release mechanisms, and mathematical kinetic models of CNP systems.
Article
Chemistry, Physical
Soheila Javadian, Khadijeh Najafi, S. Morteza Sadrpoor, Fatemeh Ektefa, Nima Dalir, Maryam Nikkhah
Summary: A nanocarrier was developed for targeted drug delivery to cancer cells, exhibiting good stability, high drug loading capacity, and higher drug release rates under acidic conditions. The nanocarrier showed comparable anticancer activity to free drugs in human breast cancer cells. Computational quantum mechanical methods were utilized to gain insight into the drug release mechanism and interactions with graphene quantum dots, showing a decrease in adsorption energy at lower pH levels.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Pharmacology & Pharmacy
Jafar Rezaie, Vahid Nejati, Monireh Mahmoodi, Mahdi Ahmadi
Summary: Extracellular vesicles (EVs), particularly MSCs-EVs, have shown great potential as a drug delivery system in nanomedicine. They can selectively deliver therapeutic agents to target cells and improve various diseases. However, there are still challenges that need to be addressed for the clinical translation of modified MSCs-EVs.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Dmitriy Moreira, Oren Regev, Nuno Basilio, Eduardo F. Marques
Summary: This study develops a delivery system based on dual light and pH responsive vesicles, which can achieve precise drug release. By adjusting the acid and base conditions and UV irradiation, the release of the drug is successfully controlled, demonstrating the potential application of vesicles as nano-carriers in acidic environments such as tumors.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biophysics
Abdollah Karami, Ahmed Ahmed, Rana Sabouni, Ghaleb A. Husseini, Miral Al Sharabati, Nour AlSawaftah, Vinod Paul
Summary: This study demonstrated the pH/Ultrasound dual-responsive capability of liposome-coated Fe-BTC for DOX delivery, showing potential as nanocarriers for drug delivery. The successful coating was verified through DLS and TEM techniques, with PBL reducing particle aggregation and improving dispersity in the release medium. TGA results showed the MOF's excellent thermal stability.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Niannian Lv, Xiaoyan Yin, Zhuoran Yang, Teng Ma, Huimin Qin, Bijin Xiong, Hao Jiang, Jintao Zhu
Summary: The precise control of diacetylene-containing peptide amphiphile (DPA) based supramolecular architectures is crucial for their polymerization behaviors and biomedical applications. This study explores the opposite polymerization behaviors of two DPAs with similar molecular structures and emphasizes the role of charge properties in their polymerization and cell interactions.
Article
Polymer Science
Ziting Yuan, Shizhen Li, Bin Sun, Kai Li, Wei Tang, Juan Xu
Summary: In this research, a shellac-based intragastric floating-retention drug delivery system (IFRDDS) was successfully fabricated using self-assembly behavior triggered by H+ and controlling agents. The system showed controlled drug-release and tunable intragastric floating-retention properties. It has great potential for the advanced medical industry.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Pawan Kumar, Navpreet Kaur, Pranav Tiwari, Anoop Kumar Gupta, Shaikh M. Mobin
Summary: The development of nontoxic, hemocompatible materials for controlled insulin delivery is a challenging task. A novel linker named H4L and a new Cu-MOF (IITI-3) were designed and synthesized. The IITI-3 exhibited high stability in biological fluid and was explored for insulin delivery by coating it with gelatin (gel@insIITI-3). The findings open up a new avenue for oral insulin delivery using the IITI-3 metal-organic framework.
ACS MATERIALS LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Weikang Luo, Ruizeng Luo, Jingjing Liu, Zhou Li, Yang Wang
Summary: This review provides a comprehensive insight into recent advances in self-powered controlled drug release systems based on nanogenerators. It emphasizes the importance of autonomous devices and discusses the challenges and prospects from clinical needs and practical translation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Weiqi Liu, Zhiqiang Li, Zixuan Wang, Ziyin Huang, Chenbo Sun, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang
Summary: Developing a drug delivery system (DDS) using a natural supramolecular hydrogel has attracted much attention due to its biocompatibility, efficacy, and adjustable performance. However, designing a functional hydrogel DDS based on the interaction between gelator and model drug is still challenging. In this study, glycyrrhetinic acid (GA) gel was used to encapsulate the model drug pyrazinamide (PZA), achieving polymorph control, stabilization, and pH-responsive release. This work provides a promising option for hydrogel-based DDS design combined with polymorph control and stabilization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Dayanne Tomaz Casimiro Silva, Igor Eduardo Silva Arruda, Jose Izak Ribeiro de Araujo, Denise de Brito Franca, Bolivar Ponciano Goulart de Lima Damasceno, Fatima de Cassia Evangelista de Oliveira, Claudia Pessoa, Monica Felts de La Roca Soares, Maria Gardennia Fonseca, Jose Lamartine Soares-Sobrinho
Summary: In this study, a controlled-release system of tamoxifen citrate (TMX) loaded in pharmaceutical montmorillonite (VHS) was evaluated for its cytotoxic activity. The results showed successful intercalation of TMX in VHS and cytotoxic activity at certain concentrations without causing damage to normal cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qiong Guo, Jiangtao Liu, Hong Yang, Zhongli Lei
Summary: Stimuli-responsive nanomaterials offer a promising approach for designing controllable drug delivery systems. This study developed a photoresponsive block copolymer with potential applications in efficient intracellular drug delivery for cancer therapy, highlighting the importance of nanotechnology in drug delivery research.
Article
Chemistry, Multidisciplinary
Shuaidong Huo, Zhihuan Liao, Pengkun Zhao, Yu Zhou, Robert Goestl, Andreas Herrmann
Summary: Mechanochemistry-based strategies provide new avenues to improve drug selectivity and overcome side effects and drug resistance. In this study, a mechano-responsive nanoswitch was constructed for the selective activation of drugs to inhibit cancer cell proliferation.
Review
Biochemistry & Molecular Biology
Antonella Barone, Nicola d'Avanzo, Maria Chiara Cristiano, Donatella Paolino, Massimo Fresta
Summary: The incidence of cancer is increasing significantly and the lack of efficacy in cancer therapies can be attributed to various factors such as delayed diagnosis, tumor regrowth, and multidrug resistance. Macrophages play a crucial role in tumor suppression or progression, and macrophage-derived extracellular vesicles (EVs) are important mediators in the tumor microenvironment. Their ability to facilitate cell-cell and organ-cell communication by delivering nucleic acids and proteins makes them potential targets for personalized anticancer nanomedicine.
Article
Pharmacology & Pharmacy
Fatima Fernandez-Alvarez, Gracia Garcia-Garcia, Jose L. Arias
Summary: The study successfully constructed a maghemite/PLGA/chitosan nanostructure with good stability, magnetism, and drug release behavior, showing significant anti-lung adenocarcinoma effect of cisplatin loading on the matrix.
Meeting Abstract
Oncology
Chang Jiang, Zhijie Ding, Marion Joy, Laura Vollmer, Dave Gau, Su Hyeong Kim, Shivendra Singh, Andreas Vogt, Partha Roy
Article
Cell Biology
Chang Jiang, William Veon, Hui Li, Kenneth R. Hallows, Partha Roy
Article
Cell Biology
Ina Ersing, Luis Nobre, Liang Wei Wang, Lior Soday, Yijie Ma, Joao A. Paulo, Yohei Narita, Camille W. Ashbaugh, Chang Jiang, Nicholas E. Grayson, Elliott Kieff, Steven P. Gygi, Michael P. Weekes, Benjamin E. Gewurz
Meeting Abstract
Oncology
Chang Jiang, William Veon, Partha Roy
Article
Endocrinology & Metabolism
Ping Zhang, Kazunori Hamamura, Chang Jiang, Liming Zhao, Hiroki Yokota
JOURNAL OF BONE AND MINERAL METABOLISM
(2012)
Article
Oncology
Souvik Chakraborty, Chang Jiang, David Gau, Michael Oddo, Zhijie Ding, Laura Vollmer, Marion Joy, William Schiemann, Donna Beer Stolz, Andreas Vogt, Sujoy Ghosh, Partha Roy
BRITISH JOURNAL OF CANCER
(2018)
Article
Cell Biology
Chang Jiang, Stephen J. Trudeau, Taek-Chin Cheong, Rui Guo, Mingxiang Teng, Liang Wei Wang, Zhonghao Wang, Chiara Pighi, Carole Gautier-Courteille, Yijie Ma, Sizun Jiang, Chong Wang, Bo Zhao, Luc Paillard, John G. Doench, Roberto Chiarle, Benjamin E. Gewurz
Article
Biochemistry & Molecular Biology
Rui Guo, Chang Jiang, Yuchen Zhang, Apurva Govande, Stephen J. Trudeau, Fang Chen, Christopher J. Fry, Rishi Puri, Emma Wolinsky, Molly Schineller, Thomas C. Frost, Makda Gebre, Bo Zhao, Lisa Giulino-Roth, John G. Doench, Mingxiang Teng, Benjamin E. Gewurz
Article
Microbiology
Rui Guo, Yuchen Zhang, Mingxiang Teng, Chang Jiang, Molly Schineller, Bo Zhao, John G. Doench, Richard J. O'Reilly, Ethel Cesarman, Lisa Giulino-Roth, Benjamin E. Gewurz
NATURE MICROBIOLOGY
(2020)
Article
Cell Biology
Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett Stone, Isaac S. Harris, Gina M. DeNicola
Summary: Cysteine plays a crucial role in maintaining cellular redox homeostasis and protecting against ferroptosis. Deprivation of cysteine leads to the unexpected accumulation of g-glutamyl-peptides in non-small-cell lung cancer cell lines as a protective mechanism against ferroptosis.
Article
Hematology
Zhonghao Wang, Rui Guo, Stephen J. Trudeau, Emma Wolinsky, Tslil Ast, Jin Hua Liang, Chang Jiang, Yijie Ma, Mingxiang Teng, Vamsi K. Mootha, Benjamin E. Gewurz
Summary: CRISPR/Cas9 analysis revealed the crucial role of ferrireductase CYB561A3 in the proliferation of endemic Burkitt lymphoma cells, with its knockout leading to severe iron starvation and damage to lysosomes and mitochondria. These findings highlight CYB561A3 as a promising therapeutic target for Burkitt lymphoma.
Article
Multidisciplinary Sciences
Chong Wang, Xiang Liu, Jun Liang, Yohei Narita, Weiyue Ding, Difei Li, Luyao Zhang, Hongbo Wang, Merrin Man Long Leong, Isabella Hou, Catherine Gerdt, Chang Jiang, Qian Zhong, Zhonghui Tang, Carmy Forney, Leah Kottyan, Matthew T. Weirauch, Benjamin E. Gewurz, Mu-sheng Zeng, Sizun Jiang, Mingxiang Teng, Bo Zhao
Summary: EBV controls lymphocyte growth and transformation by reorganizing the host genome architecture to facilitate the expression of oncogenes.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Yuchen Zhang, Chang Jiang, Stephen J. Trudeau, Yohei Narita, Bo Zhao, Mingxiang Teng, Rui Guo, Benjamin E. Gewurz
Article
Cell Biology
Chang Jiang, Zhijie Ding, Marion Joy, Souvik Chakraborty, Su Hyeong Kim, Ralph Bottcher, John Condeelis, Shivendra Singh, Partha Roy
Article
Microbiology
Yijie Ma, Michael J. Walsh, Katharina Bernhardt, Camille W. Ashbaugh, Stephen J. Trudeau, Isabelle Y. Ashbaugh, Sizun Jiang, Chang Jiang, Bo Zhao, David E. Root, John G. Doench, Benjamin E. Gewurz
CELL HOST & MICROBE
(2017)