Approaching the in vitro clinical trial: engineering organs on chips

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning

(2014) Mohammad R. Badrossamay et al.   BIOMATERIALS

Quality Metrics for Stem Cell-Derived Cardiac Myocytes

(2014) Sean P. Sheehy et al.   Stem Cell Reports

Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip

(2013) Ashutosh Agarwal et al.   ADVANCED FUNCTIONAL MATERIALS

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Metre-long cell-laden microfibres exhibit tissue morphologies and functions

(2013) Hiroaki Onoe et al.   NATURE MATERIALS

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

(2013) M. L. McCain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The contribution of cellular mechanotransduction to cardiomyocyte form and function

(2012) Sean P. Sheehy et al.   Biomechanics and Modeling in Mechanobiology

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

The promise of induced pluripotent stem cells in research and therapy

(2012) Daisy A. Robinton et al.   NATURE

The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes

(2012) György Buzsáki et al.   NATURE REVIEWS NEUROSCIENCE

Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle

(2012) M. L. McCain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Omnidirectional Printing of 3D Microvascular Networks

(2011) Willie Wu et al.   ADVANCED MATERIALS

How Do Control-Based Approaches Enter into Biology?

(2011) Philip R LeDuc et al.   Annual Review of Biomedical Engineering

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Translational research: The American way

(2011) Amy Maxmen   NATURE

Childhood brain tumors: epidemiology, current management and future directions

(2011) Ian F. Pollack et al.   Nature Reviews Neurology

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Conductive polymer-based sensors for biomedical applications

(2010) Shruti Nambiar et al.   BIOSENSORS & BIOELECTRONICS

The Economics of Drug Development: A Grim Reality and a Role for Clinical Pharmacology

(2010) P Honig et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Deconstructing the Drug Development Process: The New Face of Innovation

(2010) K I Kaitin   CLINICAL PHARMACOLOGY & THERAPEUTICS

A microfluidic brain slice perfusion chamber for multisite recording using penetrating electrodes

(2010) Alexander J. Blake et al.   JOURNAL OF NEUROSCIENCE METHODS

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Nanofiber Assembly by Rotary Jet-Spinning

(2010) Mohammad Reza Badrossamay et al.   NANO LETTERS

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY