Article
Chemistry, Medicinal
Anupreet Kharbanda, Lingtian Zhang, Debasmita Saha, Phuc Tran, Ke Xu, Ming O. Li, Yuet-Kin Leung, Brendan Frett, Hong-yu Li
Summary: TGF beta plays a crucial role in maintaining the homeostasis of epithelial and neural tissues, wound repair, and immune responses. Dysregulation of TGF beta is associated with various diseases, with modifying the tumor microenvironment being of significant clinical interest. Despite efforts, there is currently no FDA-approved therapy to inhibit the TGF beta pathway, but targeting TGF beta RI kinase remains a major approach.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Bei Pu, Xu Zhang, Tengfeng Yan, Yuntao Li, Baohui Liu, Zhihong Jian, Omer Kamal Mahgoub, Lijuan Gu, Xiaoxing Xiong, Ning Zou
Summary: Recent studies have shown that MICAL2 plays a role in promoting proliferation and migration of glioblastoma through the TGF-beta/p-Smad2/EMT-like signaling pathway. Knockdown of MICAL2 can inhibit the growth and invasion abilities of glioblastoma cells. High MICAL2 expression predicts poor prognosis in GBM patients, making it a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siqi Liu, Bingyu Shen, Juan J. Loor, Qianming Jiang, Yang Yuan, Yezi Kong, Panpan Tan, Fangyuan Zeng, Chenxu Zhao, Xiaoyan Zhu, Jianguo Wang
Summary: The present study evaluated the effects of strontium on the proliferation and differentiation of chondrocytes. It was found that strontium promotes cell proliferation and inhibits cell differentiation by directing TGF beta signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hongyu Shen, Xun Huang, Yiheng Zhao, Dongmei Wu, Kaili Xue, Jingfei Yao, Yushuang Wang, Nan Tang, Yifu Qiu
Summary: This study reveals that adipose tissue fibrosis is associated with metabolic dysfunction in obesity. The Hippo pathway interacts with TGF-beta signaling to regulate the cellular and functional shift of adipocytes, promoting extracellular matrix remodeling and the development of adipose tissue fibrosis. Macrophages produce TGF-beta and YAP/TAZ enhance SMAD2 stability, thereby contributing to fibrotic responses. Inhibition of YAP/TAZ activity can relieve adipose tissue fibrosis and improve metabolic homeostasis in obese mice.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Annamaria Fidilio, Margherita Grasso, Giuseppe Caruso, Nicolo Musso, Veronica Begni, Anna Privitera, Sebastiano Alfio Torrisi, Patrizia Campolongo, Stefania Schiavone, Fabio Tascedda, Gian Marco Leggio, Filippo Drago, Marco Andrea Riva, Filippo Caraci
Summary: Early life stressful experiences, especially during the prenatal period, can increase the risk of developing depression during adolescence. This study focuses on the prenatal stress (PNS) model in rats and its role in the development of depression. It reveals a strong interaction between the transforming growth factor-beta 1 (TGF-beta 1) gene and PNS in the pathogenesis of depression. The study also suggests that targeting the TGF-beta 1 pathway could be a potential pharmacological approach to prevent adolescent depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mingda Li, Jie Jia, Shanshan Li, Baocheng Cui, Jiao Huang, Zhaoming Guo, Kun Ma, Li Wang, Changhao Cui
Summary: This study explored the effects of tendon stem cell-derived exosomes (TSC-exo) on tendon stem cells (TSCs), finding that TSC-exo were enriched in transforming growth factor beta (TGF beta) which accelerated the proliferation and migration of TSCs. Additionally, TGF beta carried by TSC-exo activated the TGF beta-Smad2/3 and ERK1/2 signaling pathways in TSCs, ultimately regulating the downstream molecule MMP2.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Shiwen Liu, Yumeng Hu, Yue Wang, Yeqing Sun, Shu-Lan Qin, Dan Xu
Summary: The study found that endosulfan may cause excessive cell proliferation and accumulation of extracellular matrix in human renal mesangial cells through the TGF-β/Smad signaling pathway, as well as induce oxidative stress and inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Zhigang Yi, Tao Ma, Jia Liu, Wenting Tie, Yanhong Li, Jun Bai, Lijuan Li, Liansheng Zhang
Summary: This study found that LGR4 expression was significantly upregulated in multiple myeloma (MM) tissues and cells. Knockdown of LGR4 inhibited MM cell proliferation, promoted apoptosis and cell cycle arrest in G1, while overexpression showed the opposite effect. Mechanistic studies revealed that LGR4 could interact with TGF-beta 1 and activate the TGF-beta 1/Smad signaling pathway, promoting MM progression. LGR4 may be a potential new target for MM diagnosis and treatment.
CELLULAR SIGNALLING
(2023)
Editorial Material
Oncology
Kathryn M. Miller, Claire F. Friedman
Summary: SHR-1701, a bispecific fusion protein targeting PD-L1 and TGF beta, shows promising clinical efficacy in advanced/recurrent cervical cancer. A recent study provides evidence that the TGF beta pathway can be successfully targeted, and bispecific antibodies offer a novel therapeutic approach for this.
CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Zhaoxia Xu, Keqi Jia, Hui Wang, Feng Gao, Song Zhao, Fan Li, Jun Hao
Summary: HDAC5 plays a role in regulating EMT in HK2 cells by modulating TGF-beta 1, which can be influenced by the PI3K/Akt signaling pathway. METTL14, an m6A modification-associated enzyme, affects PI3K/Akt pathway through PTEN, leading to HDAC5-mediated EMT of renal tubular cells in diabetic kidney disease. Treatment with HDAC inhibitor TSA can alleviate extracellular matrix accumulation in kidneys of diabetic mice by downregulating HDAC5, TGF-beta 1, and alpha -SMA expression.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Kaiping Deng, Zhipeng Liu, Xiaodan Li, Zhen Zhang, Yixuan Fan, Qunhao Huang, Yanli Zhang, Feng Wang
Summary: Recent evidence suggests that m(6)A methylation plays a crucial role in skeletal muscle development through its regulation of TGF beta 1. Knockdown of TGF beta 1 inhibits myoblast proliferation and induces apoptosis. The presence of m(6)A in the 5 'UTR of TGF beta 1 promotes its decay and inhibits its expression, leading to a blockage in the TGF beta 1/SMAD2 signaling pathway. Targeted demethylation of TGF beta 1 m(6)A enhances the activity of the SMAD2 signaling pathway and promotes myoblast proliferation.
Article
Biochemistry & Molecular Biology
Eva Jover, Lara Matilla, Mattie Garaikoetxea, Amaya Fernandez-Celis, Pieter Muntendam, Frederic Jaisser, Patrick Rossignol, Natalia Lopez-Andres
Summary: The study found that using MR antagonists and Gal-3 inhibitors effectively blocked the inflammatory response and thrombosis induced by SARS-CoV-2 Spike protein, reducing the risk of complications in COVID-19 patients.
Article
Multidisciplinary Sciences
Fei Lu, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu, Mulin Liu
Summary: The study found that CRC patients with high GPC1 expression had poor overall survival, and GPC1 may promote proliferation and migration of CRC cells by influencing the TGF-beta 1 signaling pathway. Additionally, silencing GPC1 inhibited TGF-beta 1 levels and increased SMAD2 expression.
Article
Immunology
Liangliang Mu, Xiaoxue Yin, Hao Bai, Jiadong Li, Li Qiu, Qingliang Zeng, Shengli Fu, Jianmin Ye
Summary: In this study, it was found that MBL can reduce the proliferation of activated macrophages by regulating the cell cycle and increasing the probability of apoptosis in Nile tilapia. The inhibition of cell proliferation by MBL was closely related to the TGF-beta 1 signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Panpan Qiang, Juan Hao, Fan Yang, Yutong Han, Yi Chang, Yunqian Xian, Yunzhao Xiong, Xiaomeng Gao, Lijuan Liang, Tatsuo Shimosawa, Qingyou Xu
Summary: This study found that aldosterone induced macrophage-to-myofibroblast transition and further promoted renal fibrosis. This effect was associated with the activation of mineralocorticoid receptor (MR) and upregulation of TGF-beta 1 expression. The MR blocker could reverse these effects, suggesting that targeting the MR/TGF-beta 1 pathway may be an effective therapeutic strategy for renal fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Physiology
Jonatan Barrera-Chimal, Frederic Jaisser
Article
Pharmacology & Pharmacy
Soraya Salas-Silva, Arturo Simoni-Nieves, Maria Valeria Razori, Jocelyn Lopez-Ramirez, Jonatan Barrera-Chimal, Roberto Lazzarini, Oscar Bello, Veronica Souza, Roxana U. Miranda-Labra, Maria Concepcion Gutierrez-Ruiz, Luis Enrique Gomez-Quiroz, Marcelo G. Roma, Leticia Bucio-Ortiz
BIOCHEMICAL PHARMACOLOGY
(2020)
Review
Endocrinology & Metabolism
Jonatan Barrera-Chimal, Frederic Jaisser
DIABETES OBESITY & METABOLISM
(2020)
Article
Physiology
Talita Guerreiro Rodrigues Hungaro, Leandro Ceotto Freitas-Lima, Marcos Fernandes Gregnani, Mauro Sergio Perilhao, Thais Alves-Silva, Adriano Cleis Arruda, Jonatan Barrera-Chimal, Gabriel Rufino Estrela, Ronaldo Carvalho Araujo
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Leandro Ceotto Freitas-Lima, Alexandre Budu, Adriano Cleis Arruda, Mauro Sergio Perilhao, Jonatan Barrera-Chimal, Ronaldo Carvalho Araujo, Gabriel Rufino Estrela
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Stefanny M. Figueroa, Patricio Araos, Javier Reyes, Basile Gravez, Jonatan Barrera-Chimal, Cristian A. Amador
Summary: Overweight and obesity are common in kidney disease patients, and are associated with oxidative stress and increased urinary albumin excretion, leading to higher cardiovascular risk. Oxidized albumin levels correlate with decreased kidney function and increased blood urea nitrogen, and have a direct effect on neutrophils.
Article
Biochemistry & Molecular Biology
Isabel Amador-Martinez, Johannes Garcia-Ballhaus, Mabel Buelna-Chontal, Cesar Cortes-Gonzalez, Felipe Masso, Frederic Jaisser, Jonatan Barrera-Chimal
Summary: Uremic cardiomyopathy is a common complication in chronic kidney disease (CKD) patients and may be triggered by inflammation and transcriptional regulation leading to immune cell infiltration in the heart, ultimately causing cardiac remodeling and dysfunction.
Editorial Material
Peripheral Vascular Disease
Jonatan Barrera-Chimal, Frederic Jaisser
Article
Biochemistry & Molecular Biology
Gabriel Rufino Estrela, Leandro Ceotto Freitas-Lima, Alexandre Budu, Adriano Cleis de Arruda, Mauro Sergio Perilhao, Ricardo Ambrosio Fock, Jonatan Barrera-Chimal, Ronaldo Carvalho Araujo
Summary: This study established three mouse models of CKD-induced anemia, showing that anemia can be induced regardless of the mechanism and severity of kidney injury.
Review
Urology & Nephrology
Jonatan Barrera-Chimal, Ixchel Lima-Posada, George L. Bakris, Frederic Jaisser
Summary: Non-steroidal mineralocorticoid receptor antagonists (MRAs) show promising therapeutic effects in the treatment of diabetic kidney disease (DKD), including reducing albuminuria, slowing CKD progression, and lowering the risk of adverse cardiovascular outcomes. Compared with steroidal MRAs, non-steroidal MRAs carry a lower risk, providing potential for their use in the treatment of DKD.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Dolores Adriana Ayon-Nunez, Jacquelynne Cervantes-Torres, Carlos Cabello-Gutierrez, Sergio Rosales-Mendoza, Diana Rios-Valencia, Leonor Huerta, Raul J. Bobes, Julio Cesar Carrero, Rene Segura-Velazquez, Nora Alma Fierro, Marisela Hernandez, Joaquin Zuniga-Ramos, Gerardo Gamba, Graciela Cardenas, Emmanuel Frias-Jimenez, Luis Alonso Herrera, Gladis Fragoso, Edda Sciutto, Francisco Suarez-Guemes, Juan Pedro Laclette
Summary: COVID-19 pandemic is still ongoing and evolving worldwide, and monitoring population immunity is crucial for decision-making on returning to normality. This article describes the development of an RBD-based ELISA method for detecting specific antibodies, which can provide an indication of protective immunity against SARS-CoV-2.
Article
Biochemistry & Molecular Biology
Gerardo Gamba
Summary: Xenopus laevis oocytes play a crucial role in discovering and studying the molecular mechanisms of proteins, particularly integral membrane proteins. They are not only useful for cloning, but also for functional characterization experiments.
Article
Biochemistry & Molecular Biology
Isaac Gonzalez-Soria, Axel D. D. Soto-Valadez, Miguel Angel Martinez-Rojas, Juan Antonio Ortega-Trejo, Rosalba Perez-Villalva, Gerardo Gamba, Andrea Sanchez-Navarro, Norma A. A. Bobadilla
Summary: We found that SerpinA3K is present in urine from rats and humans with acute kidney injury (AKI) and chronic kidney disease (CKD). To understand its role in AKI, we studied SerpinA3K-deficient mice after inducing ischemia/reperfusion (I/R). The KOSA3+IR group showed ameliorated renal dysfunction, preserved antioxidant enzyme levels, and better cellular responses to hypoxic injury compared to the WT group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gabriel Rufino Estrela, Raisa Brito Santos, Alexandre Budu, Adriano Cleis de Arruda, Jonatan Barrera-Chimal, Ronaldo Carvalho Araujo
Summary: Chronic kidney disease (CKD) is a global public health problem caused by acute kidney injury (AKI) and inflammation. Inhibiting the B1 receptor (B1R) can improve AKI and prevent the transition to CKD. This study highlights the potential therapeutic role of B1R antagonism in preventing CKD following AKI.
Article
Biology
A. Budu, L. C. Freitas-Lima, A. C. de Arruda, M. S. Perilhao, J. Barrera-Chimal, R. C. Araujo, G. R. Estrela
Summary: Cisplatin is a widely used chemotherapeutic drug, but its side effects, including nephrotoxicity, can exacerbate tubular injury and tubulointerstitial fibrosis. The study found that kinin B1 receptor inhibition worsened cisplatin-induced chronic renal dysfunction, reduced the expression of the M2 marker YM1, and possibly affected the wound healing process.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)