Article
Urology & Nephrology
Seunghyeok Choi, Seon Pyo Hong, Jung Hyun Bae, Sang Heon Suh, Hosung Bae, Kyung Pyo Kang, Hyuek Jong Lee, Gou Young Koh
Summary: This study reveals that high blood glucose in diabetes mellitus activates YAP/TAZ through the canonical Hippo pathway, leading to excessive proliferation of MCs, extracellular matrix deposition, endothelial cell impairment, glomerular sclerosis, albuminuria, and reduced glomerular filtration rate, which are the hallmarks of DN. Mechanistically, YAP/TAZ bind and stabilize N-Myc protein, enhancing its transcriptional activity and eventually causing MC impairments and DN pathogenesis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stuart E. Dryer, Eun Young Kim
Summary: Diseases that cause a loss of renal function are common and can range in severity. The TRPC6 channel has shown potential as a therapeutic target for kidney diseases, but its efficacy varies depending on the specific condition. This research is important for the development of new drugs.
Article
Medicine, Research & Experimental
Yaoyu Liu, Xiaojie Li, Minglan Zhao, Yifan Wu, Yuan Xu, Xiuming Li, Lizhe Fu, Liqiao Han, Wei Zhou, Qinghong Hu, Junqi Chen, Jiuyao Zhou, Xusheng Liu, Hua Lin, Junbiao Wu
Summary: Dysfunction of mesangial cells and infiltration of macrophages are significant pathological features in glomerular lesions. Recent studies highlight the importance of the crosstalk between kidney resident cells and inflammatory cells in the development of DN.
Article
Pharmacology & Pharmacy
Ziyuan Zhang, Shufen Deng, Qiwen Shi
Summary: The effect of ISL on GMCs proliferation, ECM deposition and inflammation induced by HG was investigated. The results showed that ISL inhibited HG-induced cellular processes by inhibiting the JAK2/STAT3 pathway. This study provides new insights into the application of ISL for the treatment of diabetic nephropathy.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Manuela Harloff, Sally Prueschenk, Roland Seifert, Jens Schlossmann
Summary: The study demonstrated the beneficial effects of sGC activator cinaciguat in treating diabetic nephropathy in a mouse model. Activation of sGC may be a potential therapy option for patients with Type 1 diabetes.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xinzhe Fang, Weiyi Huang, Qiang Sun, Yang Zhao, Rui Sun, Fang Liu, Danmei Huang, Yanmei Zhang, Fenfei Gao, Bin Wang
Summary: This study demonstrates that melatonin inhibits STAT3 phosphorylation, resulting in alleviation of cellular senescence and apoptosis in diabetic nephropathy. Melatonin treatment reduced expression of senescence and apoptotic proteins, as well as positive staining for senescence markers and TUNEL-positive cells in the kidneys of diabetic nephropathy mice. Additionally, in vitro experiments showed that melatonin inhibited STAT3 phosphorylation and lowered cellular senescence and apoptosis markers, with the inhibitory effect reversed by IL-6-induced STAT3 phosphorylation.
Article
Transplantation
Michael T. Eadon, Sam Lampe, Mirza M. Baig, Kimberly S. Collins, Ricardo Melo Ferreira, Henry Mang, Ying-Hua Cheng, Daria Barwinska, Tarek M. El-Achkar, Tae-Hwi Schwantes-An, Seth Winfree, Constance J. Temm, Michael J. Ferkowicz, Kenneth W. Dunn, Katherine J. Kelly, Timothy A. Sutton, Sharon M. Moe, Ranjani N. Moorthi, Carrie L. Phillips, Pierre C. Dagher
Summary: A study comparing the clinical, histopathologic, and transcriptomic features of 48 cases of idiopathic nodular glomerulosclerosis (ING) and 751 cases of nodular diabetic nephropathy (DN) found that despite similar clinical and histopathologic characteristics, ING has distinct molecular features from nodular DN, warranting further investigation into these relationships.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Xinxin Pang, Xiaotao Hou, Chengxiao Hu, Shilong Lu, Huifang Gan, Huifei Yang, Shaowei Xiang, Jun Zhou, Hongjun Gao, Shuangqin Chen
Summary: This study found that TNC is upregulated in diabetic nephropathy patients and diabetic mice, and it induces proliferation and fibrosis of renal tubular interstitial cells through the beta-catenin pathway.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Hansen Yang, Jia Wang, Zheng Zhang, Rui Peng, Dan Lv, Handeng Liu, Yan Sun
Summary: In diabetic nephropathy, Rmrp promotes proliferation and fibrosis of mesangial cells by regulating miR-1a-3p and JunD expression levels, with Sp1 playing a key regulatory role in this process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Sarika Chaudhari, Parisa Yazdizadeh Shotorbani, Yu Tao, Ramesh Kasetti, Gulab Zode, Keisa W. Mathis, Rong Ma
Summary: This study demonstrates the expression of neogenin receptor in glomerular mesangial cells and its role in regulating ECM protein production. High glucose and oxidative stress can increase neogenin expression, while antioxidant treatment can attenuate this increase. The previously unrecognized neogenin-fibronectin pathway may contribute to glomerular injury responses during the course of diabetic nephropathy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Plant Sciences
Jialin Li, Jiawen Zhang, Meng Yang, Xiaocui Huang, Meng Zhang, Xiansong Fang, Suzhen Wu
Summary: Kirenol has reno-protective effects against diabetic nephropathy by downregulating the TGF-beta/Smads and NE-kappa B signal pathways.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Maolin Zhu, Huiyang Wang, Jiawei Chen, Huang Zhu
Summary: The study showed that sinomenine nanoliposomes have therapeutic effects on nephropathy in diabetic rats by inhibiting oxidative stress, reducing renal cell apoptosis and fibrosis, and regulating the JAK2/STAT3/SOCS1 pathway to protect renal tissues.
Article
Pharmacology & Pharmacy
Wencheng Xu, Wanci Song, Shuhe Chen, Shanshan Jin, Xue Xue, Jinwen Min, Xiaoqin Wang, Pengtao You
Summary: This study found that tetrandrine inhibited the proliferation of mesangial cells induced by enzymatically deglycosylated human IgA1 via the IgA receptor/MAPK/NF-kappa B signaling pathway, indicating that tetrandrine could be an appealing therapeutic option for IgAN.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Qiu Du, Ying-xue Fu, An-mei Shu, Xing Lv, Yu-ping Chen, Yu-yan Gao, Jing Chen, Wei Wang, Gao-hong Lv, Jin-fu Lu, Hui-qin Xu
Summary: Loganin protects the kidney from damage in diabetic nephropathy by inhibiting macrophage infiltration and activation. It regulates the RAGE/MCP-1/CCR2 signaling pathway, affecting macrophage phenotypic transformation and expression of inflammatory factors.
Review
Biochemical Research Methods
Haryana Y. Thomas, Ashlee N. Ford Versypt
Summary: Diabetic nephropathy, caused by diabetes, is a kidney complication that leads to the highest mortality rate in diabetic patients. Although the main causes of diabetic nephropathy have been identified, the mechanisms by which they affect cellular and tissue function are not fully understood. Mesangial expansion, characterized by abnormal proliferation of cells and excessive production of matrix proteins, is a major damage in diabetic nephropathy and its impact on kidney function is not well defined.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Jan Pencik, Michaela Schlederer, Wolfgang Gruber, Christine Unger, Steven M. Walker, Athena Chalaris, Isabelle Marie, Melanie R. Hassler, Tahereh Javaheri, Osman Aksoy, Jaine K. Blayney, Peter Mazal, Florian Grebien, Gerda Egger, Valeria Poli, Robert Eferl, Richard Kennedy, Falko Fend, Marcus Scharpf, Martin Braun, Sven Perner, David E. Levy, Tim Malcolm, Suzanne D. Turner, Andrea Haitel, Martin Susani, Ali Moazzami, Stefan Rose-Johns, Fritz Aberger, Olaf Merkel, Richard Moriggl, Zoran Culig, Helmut Dolznig, Lukas Kenner
Article
Oncology
Garrett Daniels, Xinmin Zhang, Xuelin Zhong, Larion Santiago, Ling Hang Wang, Xinyu Wu, Jack Y. Zhang, Fengxia Liang, Xin Li, Thomas A. Neubert, Laurey Steinke, Ying Shen, Ross Basch, Robert Schneider, David E. Levy, Peng Lee
Article
Cell Biology
Jianqiang Wu, Vincent W. Keng, Deanna M. Patmore, Jed J. Kendall, Ami V. Patel, Edwin Jousma, Walter J. Jessen, Kwangmin Choi, Barbara R. Tschida, Kevin A. T. Silverstein, Danhua Fan, Eric B. Schwartz, James R. Fuchs, Yuanshu Zou, Mi-Ok Kim, Eva Dombi, David E. Levy, Gang Huang, Jose A. Cancelas, Anat O. Stemmer-Rachamimov, Robert J. Spinner, David A. Largaespada, Nancy Ratner
Article
Microbiology
Alissa M. Pham, Felicia Gilfoy Santa Maria, Tanaya Lahiri, Eugene Friedman, Isabelle J. Marie, David E. Levy
Article
Immunology
Yichuan Xiao, Qiang Zou, Xiaoping Xie, Ting Liu, Haiyan S. Li, Zuliang Jie, Jin Jin, Hongbo Hu, Ganiraju Manyam, Li Zhang, Xuhong Cheng, Hui Wang, Isabelle Marie, David E. Levy, Stephanie S. Watowich, Shao-Cong Sun
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Multidisciplinary Sciences
Davide Genini, Lara Brambilla, Erik Laurini, Jessica Merulla, Gianluca Civenni, Shusil Pandit, Rocco D'Antuono, Laurent Perez, David E. Levy, Sabrina Pricl, Giuseppina M. Carbone, Carlo V. Catapano
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Immunology
Isabelle J. Marie, Hao-Ming Chang, David E. Levy
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Lara Brambilla, Tanaya Lahiri, Michael Cammer, David E. Levy
Article
Oncology
Tanaya Lahiri, Lara Brambilla, Joshua Andrade, Manor Askenazi, Beatrix Ueberheide, David E. Levy
Summary: Mitochondrial STAT3 regulates complex I dehydrogenase activity, impacting NAD+ regeneration, thus indirectly controlling antioxidant gene expression to promote proliferation and migration in triple-negative breast cancer cells.
MOLECULAR ONCOLOGY
(2021)
Article
Biology
Isabelle J. Marie, Lara Brambilla, Doua Azzouz, Ze Chen, Gisele Baracho, Azlann Arnett, Haiyan S. Li, Weiguo Liu, Luisa Cimmino, Pratip Chattopadhyay, Gregg Silverman, Stephanie S. Watowich, Bernard Khor, David E. Levy
Summary: In the absence of tonic interferon (IFN) signaling, mice developed inflammatory diseases spontaneously, including myeloid hyperplasia and inflammatory bowel disease. The dysbiosis in gut bacteria triggered expansion of TH17 cells and loss of splenic Treg cells, which were prevented by reducing bacterial load with antibiotics and blocking IL17 signaling. This study highlights the crucial role of tonic IFNs in regulating gut microbial ecology to maintain immune homeostasis and prevent inflammation.
Meeting Abstract
Medicine, Research & Experimental
Fei Chen, Qinghu Ren, David Levy, Peng Lee, Fangming Deng, Jonathan Melamed
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Pathology
Fei Chen, Qinghu Ren, David Levy, Peng Lee, Fangming Deng, Jonathan Melamed
Meeting Abstract
Medicine, Research & Experimental
Vamsi Parimi (Parini), Yuhe Xia, Valeria Mezzano, Varshini Vasudevaraja, Shanmugapriya Selvaraj, Cynthia Loomis, Andre Moreira, Peng Lee, David Levy, Kyung Park, Hongying Huang, Qinghu Ren, Fangming Deng, Jonathan Melamed
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Pathology
Vamsi Parimi (Parini), Yuhe Xia, Valeria Mezzano, Varshini Vasudevaraja, Shanmugapriya Selvaraj, Cynthia Loomis, Andre Moreira, Peng Lee, David Levy, Kyung Park, Hongying Huang, Qinghu Ren, Fangming Deng, Jonathan Melamed
Meeting Abstract
Biochemical Research Methods
Sang Yong Kim, Ping Zhou, Amy Sun, Crequer Amandine, Marcus Hines, Adrian Erlebacher, Sergei Koralov, David Levy
TRANSGENIC RESEARCH
(2016)