Article
Medicine, Research & Experimental
Hongzhu Li, Fengqi Sun, Shuzhi Bai, Guiquan Chang, Ren Wu, Yaxin Wei, Xin Wen, Yuxin Xi, Jinghui Hao, Altaany Zaid
Summary: Activation of the DR1-CSE/H2S pathway attenuates MC proliferation and extracellular matrix deposition in diabetic nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Kensei Taguchi, Kei Fukami
Summary: Diabetes, a leading cause of death worldwide, is expected to affect 642 million people by 2040. The concept of diabetic kidney disease (DKD) is widely accepted due to the increasing number of diabetes patients with multiple underlying diseases. Receptor for advanced glycation endproducts (RAGE), a multiligand receptor, is upregulated in patients with diabetes, hypertension, obesity, and chronic inflammation, and can be a therapeutic target for inhibiting the progression of DKD and its complications.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Wei-Jian Ni, Xi-Mei Guan, Jing Zeng, Hong Zhou, Xiao-Ming Meng, Li-Qin Tang
Summary: This study found that BBR could inhibit the abnormal proliferation of GMCs induced by HG and regulate the cell cycle through inhibiting the PI3K/Akt/AS160/GLUT1 signaling pathway, thereby inhibiting the development of DN.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Physiology
Feiying Wen, Shengmiao Zhang, Liqin Sun, Manqing Qian, Haofeng Xu
Summary: The study found that SAB can alleviate kidney histopathological changes, improve function, and reduce cell apoptosis in DN rats at various doses. SAB enhances the activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), while decreasing levels of reactive oxygen species (ROS) and malondialdehyde (MDA).
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Urology & Nephrology
Seunghyeok Choi, Seon Pyo Hong, Jung Hyun Bae, Sang Heon Suh, Hosung Bae, Kyung Pyo Kang, Hyuek Jong Lee, Gou Young Koh
Summary: This study reveals that high blood glucose in diabetes mellitus activates YAP/TAZ through the canonical Hippo pathway, leading to excessive proliferation of MCs, extracellular matrix deposition, endothelial cell impairment, glomerular sclerosis, albuminuria, and reduced glomerular filtration rate, which are the hallmarks of DN. Mechanistically, YAP/TAZ bind and stabilize N-Myc protein, enhancing its transcriptional activity and eventually causing MC impairments and DN pathogenesis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Bo Li, Guijiang Sun, Haibo Yu, Jia Meng, Fang Wei
Summary: This study found that exosomes containing circTAOK1 released from high glucose-treated glomerular epithelial cells can promote proliferation, fibrosis, and epithelial-mesenchymal transition of glomerular mesangial cells. The mechanism involves circTAOK1 regulating SMAD3 expression by sponging miR-520h.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Cell Biology
Sang-Ah Lee, Deokhwan Kim, Chanhyuk Min, Byeongjin Moon, Juyeon Lee, Hyunji Moon, Susumin Yang, Chang Sup Lee, Gwangrog Lee, Daeho Park
Summary: In this study, it was found that phagocytes are recruited to apoptotic cells being cleared through the Mcp-1-Ccr2 axis, facilitating the clearance of apoptotic cells. Increased secretion of Mcp-1 by phagocytes engulfing apoptotic cells promotes cell migration, while blockade of Ccr2 reduces cell migration to conditioned medium from phagocytes incubated with apoptotic cells.
Article
Pharmacology & Pharmacy
Ziyuan Zhang, Shufen Deng, Qiwen Shi
Summary: The effect of ISL on GMCs proliferation, ECM deposition and inflammation induced by HG was investigated. The results showed that ISL inhibited HG-induced cellular processes by inhibiting the JAK2/STAT3 pathway. This study provides new insights into the application of ISL for the treatment of diabetic nephropathy.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Florian G. Scurt, Jan Menne, Sabine Brandt, Anja Bernhardt, Peter R. Mertens, Hermann Haller, Christos Chatzikyrkou
Summary: The study found that MCP-1 was associated with the development of microalbuminuria in patients with type 2 diabetes, suggesting it may be a marker and potentially a mediator of early diabetic nephropathy.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Medicine, Research & Experimental
Yaoyu Liu, Xiaojie Li, Minglan Zhao, Yifan Wu, Yuan Xu, Xiuming Li, Lizhe Fu, Liqiao Han, Wei Zhou, Qinghong Hu, Junqi Chen, Jiuyao Zhou, Xusheng Liu, Hua Lin, Junbiao Wu
Summary: Dysfunction of mesangial cells and infiltration of macrophages are significant pathological features in glomerular lesions. Recent studies highlight the importance of the crosstalk between kidney resident cells and inflammatory cells in the development of DN.
Article
Cell Biology
Yi-Chun Tsai, Mei-Chuan Kuo, Wei-Wen Hung, Ping-Hsun Wu, Wei-An Chang, Ling-Yu Wu, Su-Chu Lee, Ya-Ling Hsu
Summary: Diabetic nephropathy (DN) is a growing concern for human health and is considered to be the main cause of end-stage renal disease worldwide. The role of exosomes in DN is still unclear, but they may play a crucial role in cross-talk among kidney cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Manuela Harloff, Sally Prueschenk, Roland Seifert, Jens Schlossmann
Summary: The study demonstrated the beneficial effects of sGC activator cinaciguat in treating diabetic nephropathy in a mouse model. Activation of sGC may be a potential therapy option for patients with Type 1 diabetes.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Won Jung Choi, Yu A. Hong, Ji Won Min, Eun Sil Koh, Hyung Duk Kim, Tae Hyun Ban, Young Soo Kim, Yong Kyun Kim, Seok Joon Shin, Seok Young Kim, Young Ok Kim, Chul Woo Yang, Yoon-Kyung Chang
Summary: This study revealed a correlation between hyperuricemia and the histopathological severity of IgAN, with a stronger association observed in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Wen Zhong, Chen Hong, Yejun Dong, Yuhui Li, Chenxi Xiao, Xinhua Liu
Summary: The epigenetic factor ASH2L plays a crucial role in high glucose-induced fibrosis and inflammation, suggesting that ASH2L regulation may be an attractive approach to attenuate the progression of diabetic nephropathy.
Article
Transplantation
Michael T. Eadon, Sam Lampe, Mirza M. Baig, Kimberly S. Collins, Ricardo Melo Ferreira, Henry Mang, Ying-Hua Cheng, Daria Barwinska, Tarek M. El-Achkar, Tae-Hwi Schwantes-An, Seth Winfree, Constance J. Temm, Michael J. Ferkowicz, Kenneth W. Dunn, Katherine J. Kelly, Timothy A. Sutton, Sharon M. Moe, Ranjani N. Moorthi, Carrie L. Phillips, Pierre C. Dagher
Summary: A study comparing the clinical, histopathologic, and transcriptomic features of 48 cases of idiopathic nodular glomerulosclerosis (ING) and 751 cases of nodular diabetic nephropathy (DN) found that despite similar clinical and histopathologic characteristics, ING has distinct molecular features from nodular DN, warranting further investigation into these relationships.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
