Article
Immunology
Xue Zhou, Yuefeng Zhang, Ning Wang
Summary: This study identified key extracellular protein genes associated with lupus nephritis, highlighting their importance in early diagnosis and predicting clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Ellen M. M. Cody, James E. E. Rose, Bin Huang, Tingting Qiu, Hermine I. I. Brunner, Prasad Devarajan
Summary: In this study, the stability of RAIL biomarkers used to monitor lupus nephritis activity in children was tested. The results showed that these biomarkers can be stored for a short period of time under clinically relevant conditions.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Brian Troyer, Jessalyn Rodgers, Bethany J. Wolf, James C. Oates, Richard R. Drake, Tamara K. Nowling
Summary: The development of nephritis increases the risk of morbidity and mortality in systemic lupus erythematosus patients. Standard induction therapies are only effective for approximately 50% of SLE patients with nephritis, and there is a critical need to predict treatment response before starting therapy. Elevated urine glycosphingolipids (GSLs) may serve as a potential biomarker for predicting treatment response in lupus nephritis patients.
Article
Immunology
Rongwei Lei, Binh Vu, Katerina Kourentzi, Sanam Soomro, Adheesha N. Danthanarayana, Jakoah Brgoch, Suma Nadimpalli, Michelle Petri, Chandra Mohan, Richard C. Willson
Summary: This study demonstrates the potential of using lateral flow assays to test urinary ALCAM for the diagnosis of active lupus nephritis. The results show high accuracy in distinguishing ALN from healthy controls and other lupus patients. Periodic monitoring of uALCAM using this easy-to-use test could help in early detection of renal involvement or disease flares in lupus patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Samar A. Soliman, Samantha Stanley, Kamala Vanarsa, Faten Ismail, Chi Chiu Mok, Chandra Mohan
Summary: The objective of this study is to determine if urine:serum fractional excretion ratios can outperform urinary biomarker proteins in identifying active renal disease in SLE. The results show that the fractional excretion ratios of most protein markers outperformed conventional disease activity markers and exhibited better accuracy in distinguishing active LN from inactive SLE. These novel biomarkers have the potential to be used for diagnostic purposes in LN assessment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Gongjun Tan, Binila Baby, Yuqiu Zhou, Tianfu Wu
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multifactorial etiology. The current diagnostic criteria for SLE have limited sensitivity and specificity, calling for the development of more accurate tools. Emerging omics technologies have potential in discovering biomarkers for SLE, but further validation is required.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sanam Soomro, Samantha Stanley, Rongwei Lei, Ramesh Saxena, Michelle Petri, Chandra Mohan
Summary: This study conducted a proteomic screen in lupus nephritis patients and identified urine proteins that are correlated with creatinine and not affected by the disease, particularly urine HVEM which can be used as an alternative to creatinine for biomarker normalization, facilitating the monitoring of lupus nephritis progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bethany Wolf, Calvin R. K. Blaschke, Sandy Mungaray, Bryan T. Weselman, Mariia Stefanenko, Mykhailo Fedoriuk, Hongxia Bai, Jessalyn Rodgers, Oleg Palygin, Richard R. Drake, Tamara K. Nowling
Summary: Lupus nephritis (LN) is a serious complication primarily affecting women with systemic lupus erythematosus. Our study found significant differences in lactosylceramide (LacCer) and N-linked glycosylated proteins (N-glycans) in the urine of LN patients, with more pronounced differences in males. Female-derived primary human renal mesangial cells (hRMCs) showed higher levels of calcium ion (Ca2+) flux, cytokine secretion, and glycosphingolipids compared to male-derived hRMCs when stimulated with LN sera. These findings suggest that urine LacCers and N-glycan profiles could serve as definitive biomarkers for LN, and the differences in males may indicate worse disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Ellen M. Cody, Scott E. Wenderfer, Kathleen E. Sullivan, Alfred H. J. Kim, Wesley Figg, Harneet Ghumman, Tingting Qiu, Bin Huang, Prasad Devarajan, Hermine Brunner
Summary: The Renal Activity Index for Lupus (RAIL) can non-invasively identify lupus nephritis (LN) and assess the efficacy of LN induction therapy. RAIL scores can differentiate clinically active LN from inactive LN or without LN. RAIL scores significantly decrease after complete LN remission.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Lu Xiao, Wei Xiao, Shudian Lin
Summary: This study aimed to identify the key genes related to active renal involvement in patients with systemic lupus erythematosus (SLE). A total of 182 differentially expressed genes (DEGs) were identified, and 12 hub genes were found to be positively associated with SLE Disease Activity Index (SLEDAI). The combination model of these hub genes showed certain diagnostic accuracy in detecting renal involvement with high disease activity in SLE patients.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Jennifer C. Davies, Emil Carlsson, Angela Midgley, Eve M. D. Smith, Ian N. Bruce, Michael W. Beresford, Christian M. Hedrich
Summary: This study validated the use of a urinary protein panel to predict active renal involvement in SLE patients and potentially predict response to rituximab treatment. The levels of certain proteins in urine were significantly higher in SLE patients with active LN, supporting the potential of these biomarkers in non-invasive routine testing for SLE patients.
Article
Pathology
Rongwei Lei, Nga Thai, Yaxi Li, Michelle Petri, Chandra Mohan
Summary: This study validated the analytical performance of the human ALCAM ELISA kit in quantifying uALCAM in patients with lupus nephritis. The results showed that the assay exhibited good accuracy, stability, and reproducibility, making it an accurate and reliable tool for early detection of renal involvement in lupus, routine outpatient monitoring of disease activity, and long-term prognostication.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Immunology
Chenling Tang, Min Fang, Gongjun Tan, Shu Zhang, Bowen Yang, Yaxi Li, Ting Zhang, Ramesh Saxena, Chandra Mohan, Tianfu Wu
Summary: The objective of this study was to discover novel circulating immune complexes (ICx) as potential biomarkers for lupus nephritis (LN). A total of 77 proteins were identified as LN-specific immunoglobulin-binding proteins, and 10 potential ICx markers were further selected using bioinformatics and single-cell RNA sequencing databases. Prolyl 3-hydroxylase 1 (P3H1), phosphatase and actin regulator 4 (PHACTR4), and regulator of G-protein signaling 12 (RGS12) ICx showed discriminative capability in distinguishing LN from healthy controls, and a biomarker panel including CD14, CD34, cystatin A, myocyte enhancer factor 2C (MEF2C), RGS12, and ubiquitin C (UBC) ICx could distinguish active LN from inactive LN.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Emil Carlsson, Alexandra Quist, Jennifer C. Davies, Angela Midgley, Eve M. D. Smith, Ian N. Bruce, Michael W. Beresford, Christian M. Hedrich
Summary: Approximately 30% of adult-onset systemic lupus erythematosus (SLE) patients develop lupus nephritis (LN). Current gold standard for LN detection, renal biopsies, is invasive and not suitable for routine monitoring. This study found that urinary proteins can be used to predict the activity of LN and support ongoing disease monitoring in adult-onset SLE patients. Further validation in larger cohorts is needed.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Sylvia Xie, Anto Sam Crosslee Louis Sam Titus, Chandra Mohan
Summary: Lupus nephritis (LN) is a highly heterogeneous disease, and diagnosis is difficult due to the varied clinical manifestations. Recent proteomic studies have identified several urinary proteins which are also cell-surface receptors. This study found that EGFR, TFRC, FOLR2, and PDGF-RB are hyperexpressed in LN kidneys, suggesting their potential as drug targets.
CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Katherine E. Lintner, Anjali Patwardhan, Lisa G. Rider, Rabheh Abdul-Aziz, Yee Ling Wu, Emeli Lundstrom, Leonid Padyukov, Bi Zhou, Alaaedin Alhomosh, David Newsom, Peter White, Karla B. Jones, Terrance P. O'Hanlon, Frederick W. Miller, Charles H. Spencer, Chack Yung Yu
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Urology & Nephrology
Andrew L. Schwaderer, Huanyu Wang, SungHwan Kim, Jennifer M. Kline, Dong Liang, Pat D. Brophy, Kirk M. McHugh, George C. Tseng, Vijay Saxena, Evan Barr-Beare, Keith R. Pierce, Nader Shaikh, J. Robert Manak, Daniel M. Cohen, Brian Becknell, John D. Spencer, Peter B. Baker, Chack-Yung Yu, David S. Hains
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Article
Multidisciplinary Sciences
Lingling Shi, Yunfei Guo, Chengliang Dong, John Huddleston, Hui Yang, Xiaolu Han, Aisi Fu, Quan Li, Na Li, Siyi Gong, Katherine E. Lintner, Qiong Ding, Zou Wang, Jiang Hu, Depeng Wang, Feng Wang, Lin Wang, Gholson J. Lyon, Yongtao Guan, Yufeng Shen, Oleg V. Evgrafov, James A. Knowles, Francoise Thibaud-Nissen, Valerie Schneider, Chack-Yung Yu, Libing Zhou, Evan E. Eichler, Kwok-Fai So, Kai Wang
NATURE COMMUNICATIONS
(2016)
Article
Rheumatology
Ji Yih Chen, Yee Ling Wu, Mo Yin Mok, Yeong-Jian Jan Wu, Katherine E. Lintner, Chin-Man Wang, Erwin K. Chung, Yan Yang, Bi Zhou, Huanyu Wang, Denise J. H. C. Yu, Alaaedin Alhomosh, Karla Jones, Charles H. Spencer, Haikady N. Nagaraja, Yu Lung Lau, Chak-Sing Lau, C. Yung Yu
ARTHRITIS & RHEUMATOLOGY
(2016)
Review
Immunology
Katherine E. Lintner, Yee Ling Wu, Yan Yang, Charles H. Spencer, Georges Hauptmann, Lee A. Hebert, John P. Atkinson, C. Yung Yu
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Pediatrics
Rabheh Abdul-Aziz, Chack-Yung Yu, Brent Adler, Sharon Bout-Tabaku, Katherine E. Lintner, Melissa Moore-Clingenpeel, Charles H. Spencer
PEDIATRIC RHEUMATOLOGY
(2017)
Article
Genetics & Heredity
Christopher J. Lessard, Indra Adrianto, John A. Ice, Graham B. Wiley, Jennifer A. Kelly, Stuart B. Glenn, Adam J. Adler, He Li, Astrid Rasmussen, Adrienne H. Williams, Julie Ziegler, Mary E. Comeau, Miranda Marion, Benjamin E. Wakeland, Chaoying Liang, Paula S. Ramos, Kiely M. Grundahl, Caroline J. Gallant, Marta E. Alarcon-Riquelme, Graciela S. Alarcon, Juan-Manuel Anaya, Sang-Cheol Bae, Susan A. Boackle, Elizabeth E. Brown, Deh-Ming Chang, Soo-Kyung Cho, Lindsey A. Criswell, Jeffrey C. Edberg, Barry I. Freedman, Gary S. Gilkeson, Chaim O. Jacob, Judith A. James, Diane L. Kamen, Robert P. Kimberly, Jae-Hoon Kim, Javier Martin, Joan T. Merrill, Timothy B. Niewold, So-Yeon Park, Michelle A. Petri, Bernardo A. Pons-Estel, Rosalind Ramsey-Goldman, John D. Reveille, R. Hal Scofield, Yeong Wook Song, Anne M. Stevens, Betty P. Tsao, Luis M. Vila, Timothy J. Vyse, Chack-Yung Yu, Joel M. Guthridge, Kenneth M. Kaufman, John B. Harley, Edward K. Wakeland, Carl D. Langefeld, Patrick M. Gaffney, Courtney G. Montgomery, Kathy L. Moser
AMERICAN JOURNAL OF HUMAN GENETICS
(2012)
Article
Genetics & Heredity
Michael Mueller, Paula Barros, Abigail S. Witherden, Amy L. Roberts, Zhou Zhang, Helmut Schaschl, Chack-Yung Yu, Matthew E. Hurles, Catherine Schaffner, R. Andres Floto, Laurence Game, Karyn Meltz Steinberg, Richard K. Wilson, Tina A. Graves, Evan E. Eichler, H. Terence Cook, Timothy J. Vyse, Timothy J. Aitman
AMERICAN JOURNAL OF HUMAN GENETICS
(2013)
Article
Rheumatology
Kenneth M. Kaufman, Jian Zhao, Jennifer A. Kelly, Travis Hughes, Adam Adler, Elena Sanchez, Joshua O. Ojwang, Carl D. Langefeld, Julie T. Ziegler, Adrienne H. Williams, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Rita M. Cantor, Jennifer M. Grossman, Bevra H. Hahn, Yeong Wook Song, Chack-Yung Yu, Judith A. James, Joel M. Guthridge, Elizabeth E. Brown, Graciela S. Alarcon, Robert P. Kimberly, Jeffrey C. Edberg, Rosalind Ramsey-Goldman, Michelle A. Petri, John D. Reveille, Luis M. Vila, Juan-Manuel Anaya, Susan A. Boackle, Anne M. Stevens, Barry I. Freedman, Lindsey A. Criswell, Bernardo A. Pons-Estel, Joo-Hyun Lee, Ji-Seon Lee, Deh-Ming Chang, R. Hal A. Scofield, Gary S. Gilkeson, Joan T. Merrill, Timothy B. Niewold, Timothy James Vyse, Sang-Cheol Bae, Marta E. Alarcon-Riquelme, Chaim O. Jacob, Kathy Moser Sivils, Patrick M. Gaffney, John B. Harley, Amr H. Sawalha, Betty P. Tsao
ANNALS OF THE RHEUMATIC DISEASES
(2013)
Article
Rheumatology
Rachel Kaiser, Kimberly E. Taylor, Yun Deng, Jian Zhao, Yonghong Li, Joanne Nititham, Monica Chang, Joseph Catanese, Ann B. Begovich, Elizabeth E. Brown, Jeffrey C. Edberg, Gerald McGwin, Graciela S. Alarcon, Rosalind Ramsey-Goldman, John D. Reveille, Luis M. Vila, Michelle Petri, Robert P. Kimberly, Xuebing Feng, Lingyun Sun, Nan Shen, Wei Li, Jian-Xin Lu, Edward K. Wakeland, Quan-Zhen Li, Wanling Yang, Yu-Lung Lau, Fei-Lan Liu, Deh-Ming Chang, Chack-Yung Yu, Yeong W. Song, Hwee Siew Howe, Betty P. Tsao, Lindsey A. Criswell
ARTHRITIS AND RHEUMATISM
(2013)
Article
Rheumatology
D. J. Birmingham, L. A. Hebert, H. Song, W. T. Noonan, B. H. Rovin, H. N. Nagaraja, C. Y. Yu
Article
Endocrinology & Metabolism
Suzanne E. Kingery, Yee Ling Wu, Bi Zhou, Robert P. Hoffman, C. Yung Yu
PEDIATRIC DIABETES
(2012)
Article
Genetics & Heredity
Daisuke Sakurai, Jian Zhao, Yun Deng, Jennifer A. Kelly, Elizabeth E. Brown, John B. Harley, Sang-Cheol Bae, Marta E. Alarcon-Riqueime, Jeffrey C. Edberg, Robert P. Kimberly, Rosalind Ramsey-Goldman, Michelle A. Petri, John D. Reveille, Luis M. Vila, Graciela S. Alarcon, Kenneth M. Kaufman, Timothy J. Vyse, Chaim O. Jacob, Patrick M. Gaffney, Kathy Moser Sivils, Judith A. James, Diane L. Kamen, Gary S. Gilkeson, Timothy B. Niewold, Joan T. Merrill, R. Hal Scofield, Lindsey A. Criswell, Anne M. Stevens, Susan A. Boackle, Jae-Hoon Kim, Jiyoung Choi, Bernardo A. Pons-Estel, Barry I. Freedman, Juan-Manuel Anaya, Javier Martin, C. Yung Yu, Deh-Ming Chang, Yeong Wook Song, Carl D. Langefeld, Weiling Chen, Jennifer M. Grossman, Rita M. Cantor, Bevra H. Hahn, Betty P. Tsao
Editorial Material
Immunology
Chack-Yung Yu, Stacy P. Ardoin
Summary: The study demonstrates successful immunotherapy of a detrimental gastrointestinal disease using the complement inhibitor eculizumab.
Review
Endocrinology & Metabolism
Melanie Copenhaver, Chack-Yung Yu, Robert P. Hoffman
CURRENT DIABETES REVIEWS
(2019)