The 2'-5'-Oligoadenylate Synthetase 3 Enzyme Potently Synthesizes the 2'-5'-Oligoadenylates Required for RNase L Activation

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

(2014) Hao Huang et al.   MOLECULAR CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

(2013) J. Donovan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes

(2012) Yuchen Han et al.   Cell Reports

The Oligoadenylate Synthetase Family: An Ancient Protein Family with Multiple Antiviral Activities

(2010) Helle Kristiansen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Distinct Antiviral Roles for Human 2',5'-Oligoadenylate Synthetase Family Members against Dengue Virus Infection

(2009) R.-J. Lin et al.   JOURNAL OF IMMUNOLOGY

Differential Regulation of the OASL and OAS1 Genes in Response to Viral Infections

(2009) Jesper Melchjorsen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

2’-5’ Oligoadenylate synthetase shares active site architecture with the archaeal CCA-adding enzyme

(2008) S. Torralba et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The large form of human 2′,5′-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus

(2008) Anne-Claire Bréhin et al.   VIROLOGY