Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 Antigens
出版年份 2014 全文链接
标题
Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 Antigens
作者
关键词
-
出版物
JOURNAL OF VIROLOGY
Volume 88, Issue 6, Pages 3392-3410
出版商
American Society for Microbiology
发表日期
2014-01-04
DOI
10.1128/jvi.02723-13
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Clinical applications of attenuated MVA poxvirus strain
- (2013) Carmen Elena Gómez et al. Expert Review of Vaccines
- Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy
- (2013) R. P. Sumner et al. JOURNAL OF GENERAL VIROLOGY
- Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence
- (2013) B. J. Ferguson et al. JOURNAL OF GENERAL VIROLOGY
- Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection
- (2013) C. T. O. Benfield et al. JOURNAL OF GENERAL VIROLOGY
- Safety and Immunogenicity of DNA and MVA HIV-1 Subtype C Vaccine Prime-Boost Regimens: A Phase I Randomised Trial in HIV-Uninfected Indian Volunteers
- (2013) Sanjay Mehendale et al. PLoS One
- Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways
- (2013) Juan García-Arriaza et al. PLoS One
- Deletion of the Vaccinia Virus Gene A46R, Encoding for an Inhibitor of TLR Signalling, Is an Effective Approach to Enhance the Immunogenicity in Mice of the HIV/AIDS Vaccine Candidate NYVAC-C
- (2013) Beatriz Perdiguero et al. PLoS One
- Recombinant MVA vaccines: dispelling the myths
- (2013) Matthew G. Cottingham et al. VACCINE
- Human Immunodeficiency Virus Vaccine Trials
- (2013) R. J. O'Connell et al. Cold Spring Harbor Perspectives in Medicine
- Poxviral Protein A46 Antagonizes Toll-like Receptor 4 Signaling by Targeting BB Loop Motifs in Toll-IL-1 Receptor Adaptor Proteins to Disrupt Receptor:Adaptor Interactions
- (2012) Julianne Stack et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Removal of Vaccinia Virus Genes That Block Interferon Type I and II Pathways Improves Adaptive and Memory Responses of the HIV/AIDS Vaccine Candidate NYVAC-C in Mice
- (2012) C. E. Gomez et al. JOURNAL OF VIROLOGY
- Deletion of Specific Immune-Modulatory Genes from Modified Vaccinia Virus Ankara-Based HIV Vaccines Engenders Improved Immunogenicity in Rhesus Macaques
- (2012) D. A. Garber et al. JOURNAL OF VIROLOGY
- Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial
- (2012) Barton F. Haynes et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improving the MVA Vaccine Potential by Deleting the Viral Gene Coding for the IL-18 Binding Protein
- (2012) Juliana Falivene et al. PLoS One
- Deletion of the Viral Anti-Apoptotic Gene F1L in the HIV/AIDS Vaccine Candidate MVA-C Enhances Immune Responses against HIV-1 Antigens
- (2012) Beatriz Perdiguero et al. PLoS One
- Poxvirus vectors as HIV/AIDS vaccines in humans
- (2012) Carmen Elena Gómez et al. Human Vaccines & Immunotherapeutics
- Phase 1 Safety and Immunogenicity Testing of DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-like Particles
- (2011) Paul A. Goepfert et al. JOURNAL OF INFECTIOUS DISEASES
- The HIV/AIDS Vaccine Candidate MVA-B Administered as a Single Immunogen in Humans Triggers Robust, Polyfunctional, and Selective Effector Memory T Cell Responses to HIV-1 Antigens
- (2011) C. E. Gomez et al. JOURNAL OF VIROLOGY
- Poxvirus A46 protein binds to TIR domain-containing Mal/TIRAP via an α-helical sub-domain
- (2011) Shun-ichiro Oda et al. MOLECULAR IMMUNOLOGY
- Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
- (2011) Scott G. Hansen et al. NATURE
- Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
- (2011) Esther D. Quakkelaar et al. PLoS One
- Dendritic Cells Exposed to MVA-Based HIV-1 Vaccine Induce Highly Functional HIV-1-Specific CD8+ T Cell Responses in HIV-1-Infected Individuals
- (2011) Núria Climent et al. PLoS One
- A Candidate HIV/AIDS Vaccine (MVA-B) Lacking Vaccinia Virus Gene C6L Enhances Memory HIV-1-Specific T-Cell Responses
- (2011) Juan García-Arriaza et al. PLoS One
- Improved NYVAC-Based Vaccine Vectors
- (2011) Karen V. Kibler et al. PLoS One
- A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects☆☆☆
- (2011) Michael C. Keefer et al. VACCINE
- Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02)
- (2011) Felipe García et al. VACCINE
- Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania
- (2011) Muhammad Bakari et al. VACCINE
- Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
- (2011) Leonie Unterholzner et al. PLoS Pathogens
- Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence
- (2011) Carlos Maluquer de Motes et al. PLoS Pathogens
- Strong HIV-Specific CD4+ and CD8+ T-Lymphocyte Proliferative Responses in Healthy Individuals Immunized with an HIV-1 DNA Vaccine and Boosted with Recombinant Modified Vaccinia Virus Ankara Expressing HIV-1 Genes
- (2010) S. Aboud et al. Clinical and Vaccine Immunology
- Induction of Immunity to Human Immunodeficiency Virus Type-1 by Vaccination
- (2010) M. Juliana McElrath et al. IMMUNITY
- Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule
- (2010) T. Lysakova-Devine et al. JOURNAL OF IMMUNOLOGY
- Selective Induction of Host Genes by MVA-B, a Candidate Vaccine against HIV/AIDS
- (2010) S. Guerra et al. JOURNAL OF VIROLOGY
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
- (2010) Taro Kawai et al. NATURE IMMUNOLOGY
- Phase 1 Safety and Immunogenicity Evaluation of ADMVA, a Multigenic, Modified Vaccinia Ankara-HIV-1 B'/C Candidate Vaccine
- (2010) Sandhya Vasan et al. PLoS One
- Insertion of Vaccinia Virus C7L Host Range Gene into NYVAC-B Genome Potentiates Immune Responses against HIV-1 Antigens
- (2010) José Luis Nájera et al. PLoS One
- Immunogenic Profiling in Mice of a HIV/AIDS Vaccine Candidate (MVA-B) Expressing Four HIV-1 Antigens and Potentiation by Specific Gene Deletions
- (2010) Juan García-Arriaza et al. PLoS One
- Phase I Safety and Immunogenicity Evaluation of MVA-CMDR, a Multigenic, Recombinant Modified Vaccinia Ankara-HIV-1 Vaccine Candidate
- (2010) Jeffrey R. Currier et al. PLoS One
- A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history
- (2010) José M González et al. Virology Journal
- Poxvirus vector-based HIV vaccines
- (2010) Giuseppe Pantaleo et al. Current Opinion in HIV and AIDS
- A Phase 1 Study to Evaluate the Safety and Immunogenicity of a Recombinant HIV Type 1 Subtype C-Modified Vaccinia Ankara Virus Vaccine Candidate in Indian Volunteers
- (2009) Vadakkuppatu Devasenapathi Ramanathan et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- The Interferon System and Vaccinia Virus Evasion Mechanisms
- (2009) Beatriz Perdiguero et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Analysis of Vaccinia Virus−Host Protein−Protein Interactions: Validations of Yeast Two-Hybrid Screenings
- (2009) Leiliang Zhang et al. JOURNAL OF PROTEOME RESEARCH
- Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
- (2009) Scott G Hansen et al. NATURE MEDICINE
- Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
- (2009) Supachai Rerks-Ngarm et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expanding the Repertoire of Modified Vaccinia Ankara-Based Vaccine Vectors via Genetic Complementation Strategies
- (2009) David A. Garber et al. PLoS One
- Structural Basis for Targeting of Human RNA Helicase DDX3 by Poxvirus Protein K7
- (2009) Shun-ichiro Oda et al. STRUCTURE
- Multimeric soluble CD40 ligand (sCD40L) efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus vectors MVA and NYVAC expressing HIV antigens
- (2009) Carmen E. Gómez et al. VACCINE
- Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity
- (2009) Lindvi Gudmundsdotter et al. VACCINE
- Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome
- (2009) Julie Delaloye et al. PLoS Pathogens
- Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation
- (2008) Martina Schröder et al. EMBO JOURNAL
- Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection
- (2008) N. Jacobs et al. JOURNAL OF GENERAL VIROLOGY
- Broad Immunogenicity of a Multigene, Multiclade HIV‐1 DNA Vaccine Boosted with Heterologous HIV‐1 Recombinant Modified Vaccinia Virus Ankara
- (2008) Eric Sandström et al. JOURNAL OF INFECTIOUS DISEASES
- Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3
- (2008) Arnout P. Kalverda et al. JOURNAL OF MOLECULAR BIOLOGY
- Differential CD4+ versus CD8+ T-Cell Responses Elicited by Different Poxvirus-Based Human Immunodeficiency Virus Type 1 Vaccine Candidates Provide Comparable Efficacies in Primates
- (2008) P. Mooij et al. JOURNAL OF VIROLOGY
- Recombination-Mediated Genetic Engineering of a Bacterial Artificial Chromosome Clone of Modified Vaccinia virus Ankara (MVA)
- (2008) Matthew G. Cottingham et al. PLoS One
- Inhibition of IκB Kinase by Vaccinia Virus Virulence Factor B14
- (2008) Ron A.-J. Chen et al. PLoS Pathogens
- Lessons from IAVI-006, a Phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers
- (2008) A. Guimarães-Walker et al. VACCINE
- Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa
- (2008) Walter Jaoko et al. VACCINE
- Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis
- (2008) Stephen C. Graham et al. PLoS Pathogens
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now