Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways

Attenuated poxvirus vectors MVA and NYVAC as promising vaccine cadidates against HIV/AIDS

(2014) Mariano Esteban   Human vaccines & immunotherapeutics

Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy

(2013) R. P. Sumner et al.   JOURNAL OF GENERAL VIROLOGY

Removal of Vaccinia Virus Genes That Block Interferon Type I and II Pathways Improves Adaptive and Memory Responses of the HIV/AIDS Vaccine Candidate NYVAC-C in Mice

(2012) C. E. Gomez et al.   JOURNAL OF VIROLOGY

Deletion of Specific Immune-Modulatory Genes from Modified Vaccinia Virus Ankara-Based HIV Vaccines Engenders Improved Immunogenicity in Rhesus Macaques

(2012) D. A. Garber et al.   JOURNAL OF VIROLOGY

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improving the MVA Vaccine Potential by Deleting the Viral Gene Coding for the IL-18 Binding Protein

(2012) Juliana Falivene et al.   PLoS One

Deletion of the Viral Anti-Apoptotic Gene F1L in the HIV/AIDS Vaccine Candidate MVA-C Enhances Immune Responses against HIV-1 Antigens

(2012) Beatriz Perdiguero et al.   PLoS One

Innate immune interferon responses to Human immunodeficiency virus-1 infection

(2012) Rose Hughes et al.   REVIEWS IN MEDICAL VIROLOGY

Poxvirus vectors as HIV/AIDS vaccines in humans

(2012) Carmen Elena Gómez et al.   Human Vaccines & Immunotherapeutics

MVA and NYVAC as Vaccines against Emergent Infectious Diseases and Cancer

(2011) Carmen E. Gomez et al.   CURRENT GENE THERAPY

Phase 1 Safety and Immunogenicity Testing of DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-like Particles

(2011) Paul A. Goepfert et al.   JOURNAL OF INFECTIOUS DISEASES

The HIV/AIDS Vaccine Candidate MVA-B Administered as a Single Immunogen in Humans Triggers Robust, Polyfunctional, and Selective Effector Memory T Cell Responses to HIV-1 Antigens

(2011) C. E. Gomez et al.   JOURNAL OF VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors

(2011) Esther D. Quakkelaar et al.   PLoS One

Dendritic Cells Exposed to MVA-Based HIV-1 Vaccine Induce Highly Functional HIV-1-Specific CD8+ T Cell Responses in HIV-1-Infected Individuals

(2011) Núria Climent et al.   PLoS One

A Candidate HIV/AIDS Vaccine (MVA-B) Lacking Vaccinia Virus Gene C6L Enhances Memory HIV-1-Specific T-Cell Responses

(2011) Juan García-Arriaza et al.   PLoS One

Improved NYVAC-Based Vaccine Vectors

(2011) Karen V. Kibler et al.   PLoS One

A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects☆☆☆

(2011) Michael C. Keefer et al.   VACCINE

Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02)

(2011) Felipe García et al.   VACCINE

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

(2011) Leonie Unterholzner et al.   PLoS Pathogens

Serum-induced suppression of interferon (IFN) activity. Lack of evidence for the presence of specific autoantibodies to IFN-α in normal human sera

(2010) M. B. HANSEN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays

(2010) S Kutscher et al.   GENE THERAPY

CD8+T-cell-mediated control of HIV-1 and SIV infection

(2010) Stephanie A. Freel et al.   IMMUNOLOGIC RESEARCH

Selective Induction of Host Genes by MVA-B, a Candidate Vaccine against HIV/AIDS

(2010) S. Guerra et al.   JOURNAL OF VIROLOGY

Phase 1 Safety and Immunogenicity Evaluation of ADMVA, a Multigenic, Modified Vaccinia Ankara-HIV-1 B'/C Candidate Vaccine

(2010) Sandhya Vasan et al.   PLoS One

Insertion of Vaccinia Virus C7L Host Range Gene into NYVAC-B Genome Potentiates Immune Responses against HIV-1 Antigens

(2010) José Luis Nájera et al.   PLoS One

Immunogenic Profiling in Mice of a HIV/AIDS Vaccine Candidate (MVA-B) Expressing Four HIV-1 Antigens and Potentiation by Specific Gene Deletions

(2010) Juan García-Arriaza et al.   PLoS One

Phase I Safety and Immunogenicity Evaluation of MVA-CMDR, a Multigenic, Recombinant Modified Vaccinia Ankara-HIV-1 Vaccine Candidate

(2010) Jeffrey R. Currier et al.   PLoS One

A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history

(2010) José M González et al.   Virology Journal

Poxvirus vector-based HIV vaccines

(2010) Giuseppe Pantaleo et al.   Current Opinion in HIV and AIDS

A Phase 1 Study to Evaluate the Safety and Immunogenicity of a Recombinant HIV Type 1 Subtype C-Modified Vaccinia Ankara Virus Vaccine Candidate in Indian Volunteers

(2009) Vadakkuppatu Devasenapathi Ramanathan et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The Interferon System and Vaccinia Virus Evasion Mechanisms

(2009) Beatriz Perdiguero et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expanding the Repertoire of Modified Vaccinia Ankara-Based Vaccine Vectors via Genetic Complementation Strategies

(2009) David A. Garber et al.   PLoS One

Structural Basis for Targeting of Human RNA Helicase DDX3 by Poxvirus Protein K7

(2009) Shun-ichiro Oda et al.   STRUCTURE

Multimeric soluble CD40 ligand (sCD40L) efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus vectors MVA and NYVAC expressing HIV antigens

(2009) Carmen E. Gómez et al.   VACCINE

Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

(2009) Julie Delaloye et al.   PLoS Pathogens

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Broad Immunogenicity of a Multigene, Multiclade HIV‐1 DNA Vaccine Boosted with Heterologous HIV‐1 Recombinant Modified Vaccinia Virus Ankara

(2008) Eric Sandström et al.   JOURNAL OF INFECTIOUS DISEASES

Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3

(2008) Arnout P. Kalverda et al.   JOURNAL OF MOLECULAR BIOLOGY

Differential CD4+ versus CD8+ T-Cell Responses Elicited by Different Poxvirus-Based Human Immunodeficiency Virus Type 1 Vaccine Candidates Provide Comparable Efficacies in Primates

(2008) P. Mooij et al.   JOURNAL OF VIROLOGY

Recombination-Mediated Genetic Engineering of a Bacterial Artificial Chromosome Clone of Modified Vaccinia virus Ankara (MVA)

(2008) Matthew G. Cottingham et al.   PLoS One

RIG-I Mediates the Co-Induction of Tumor Necrosis Factor and Type I Interferon Elicited by Myxoma Virus in Primary Human Macrophages

(2008) Fuan Wang et al.   PLoS Pathogens

The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22

(2008) Stephen D. Barr et al.   PLoS Pathogens