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Biochemistry & Molecular Biology
Sheng Yan, Bin Peng, Shifeng Kan, Guangcan Shao, Zhikai Xiahou, Xiangyan Tang, Yong-Xiang Chen, Meng-Qiu Dong, Xiao Liu, Xingzhi Xu, Jing Li
Summary: This article investigates the impact of O-GlcNAc transferase (OGT) on PLK1, and finds that OGT can modify PLK1 through O-GlcNAcylation. Further research reveals that the T291A and T291N mutations increase the stability of PLK1 and lead to chromosome segregation defects and uterine carcinoma. The findings suggest that OGT exerts its mitotic function partially through O-GlcNAcylation of PLK1, which may contribute to tumorigenesis by elevating O-GlcNAc levels.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
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Biochemistry & Molecular Biology
Citlaly Gutierrez-Rodelo, Araceli Arellano-Plancarte, Judith Hernandez-Aranda, Huguet Landa-Galvan, G. Karina Parra-Mercado, Nicole J. Moreno-Licona, Karla D. Hernandez-Gonzalez, Kevin J. Catt, Rafael Villalobos-Molina, J. Alberto Olivares-Reyes
Summary: Angiotensin II plays a critical role in regulating insulin signaling in the cardiovascular system and metabolic tissues. However, in adipose cells, it inhibits insulin actions through activation of PKC, leading to insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
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Oncology
Yuan Zhang, Kimberly J. Newsom, Mei Zhang, Jeffry S. Kelley, Petr Starostik
Summary: FLT3-ITD mutation in AML results in upregulation of de novo creatine biosynthesis through the STAT5 signaling pathway, leading to increased glycine amidinotransferase expression and higher creatinine levels. Inhibiting FLT3-ITD or targeting the creatine metabolic pathway can decrease cell proliferation and induce cell apoptosis in FLT3-ITD-mutant AML, potentially via the AMPK/mTOR signaling pathway.
MOLECULAR CANCER RESEARCH
(2022)
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Cell Biology
Tao Wang, Xinlei Ba, Xiaonan Zhang, Na Zhang, Guowen Wang, Bin Bai, Tong Li, Jiahui Zhao, Yanjiao Zhao, Yang Yu, Bing Wang
Summary: This study reveals that PTPN18 acts as a suppressor of breast cancer metastasis by dephosphorylating ETS1 and provides a new strategy for the treatment of breast cancer metastasis.
CELL DEATH & DISEASE
(2022)
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Oncology
Miaoling Tang, Meisongzhu Yang, Geyan Wu, Shuang Mo, Xingui Wu, Shuxia Zhang, Ruyuan Yu, Yameng Hu, Yingru Xu, Ziwen Li, Xinyi Liao, Jun Li, Libing Song
Summary: In liver cancer cells, the upregulation of MFF mediated by the TBX19/PRMT1 complex promotes mitochondrial fission and tumor-initiating capacity, indicating that PRMT1 may be a viable therapeutic target in liver cancer.
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Biochemistry & Molecular Biology
Isabella E. Maudlin, Jean D. Beggs
Summary: The study revealed that in yeast, Bur1 kinase enhances co-transcriptional spliceosome assembly and pre-mRNA splicing by augmenting Spt5 phosphorylation, while depletion of Ctk1 kinase does not affect these processes.
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Cell Biology
Ehud Wainstein, Galia Maik-Rachline, John Blenis, Rony Seger
Summary: AKT is a central signaling protein kinase that plays a critical role in cellular survival metabolism and cell growth regulation, with its different isoforms having distinct subcellular localization and functions.
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Cell Biology
Congcong Zhu, Long Zhang, Senlin Zhao, Weixing Dai, Yun Xu, Yuqin Zhang, Hongtu Zheng, Weiqi Sheng, Ye Xu
Summary: UPF1 is upregulated in colorectal cancer and predicts a poor prognosis, while also enhancing chemoresistance to oxaliplatin through regulating TOP2A activity and maintaining stemness. This finding may provide a new therapeutic strategy for CRC patients with oxaliplatin resistance.
CELL DEATH & DISEASE
(2021)
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Multidisciplinary Sciences
Wenting Shen, Ziqing Gao, Kaiyue Chen, Alusi Zhao, Qi Ouyang, Chunxiong Luo
Summary: Cells respond to environmental changes by modulating gene expression. In this study, the responses to osmotic stress in glucose-limited and glucose-rich environments were compared. It was found that cells exhibited a stronger osmotic gene expression response and larger integral of Hog1 nuclear localization under glucose-limited conditions. The regulatory mechanism of osmoresponse was derived and a reserve flux-dependent stress-defense strategy was proposed.
Review
Biochemistry & Molecular Biology
Lucia Gutierrez-Chamorro, Eudald Felip, Ifeanyi Jude Ezeonwumelu, Mireia Margeli, Ester Ballana
Summary: CDKs play crucial roles in cell proliferation and viral infections, with specific CDK inhibitors showing potential for treating viral infections as a novel therapeutic strategy. The development and repurposing of CDK inhibitors may offer new options in combating both known and emerging viruses.
TRENDS IN MICROBIOLOGY
(2021)
Article
Oncology
Dan Huang, Cristel V. Camacho, Sara Martire, Anusha Nagari, Rohit Setlem, Xuan Gong, Andrea D. Edwards, Shu-Ping Chiu, Laura A. Banaszynski, W. Lee Kraus
Summary: Recent studies have found cancer-associated mutations in histone genes, resulting in the expression of mutant core histones called oncohistones. These mutations affect cell growth and inhibit ADP-ribosylation at specific sites in wild-type histones. Some mutations significantly alter chromatin accessibility, gene expression, and acetylation modification. This study reveals the significance of cancer-driving mutations in histones as sites of ADP-ribosylation and their role in evading the growth-regulating effects of PARP1.
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Multidisciplinary Sciences
Dino Gobelli, Pablo Serrano-Lorenzo, Maria J. Esteban-Amo, Julia Serna, M. Teresa Perez-Garcia, Antonio Orduna, Alexis A. Jourdain, Miguel A. Martin-Casanueva, Miguel A. . de la Fuente, Maria Simarro
Summary: The subunits Sdha and Sdhb of the mitochondrial electron transport chain play important roles in the respiration and effector responses of macrophages. Their absence impairs the stabilization of HIF-1 alpha and the production of the pro-inflammatory cytokine IL-1 beta in response to LPS stimulation, and also inhibits the production of IL-10. This is due to the excessive accumulation of mitochondrial reactive oxygen species (mitoROS) and the inhibition of Stat3 tyrosine phosphorylation caused by the absence of Sdha and Sdhb.
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Biochemistry & Molecular Biology
James M. Murphy, Kyuho Jeong, Eun-Young Erin Ahn, Ssang-Taek Steve Lim
Summary: This study reveals that FAK plays a crucial role in regulating cell cycle progression potentially through the CDK4/6 pathway. Inhibition of FAK leads to increased nuclear localization and G1 arrest in melanoma cells. Mechanistically, nuclear FAK interacts with CDK4/6 and promotes their degradation through recruitment of CDH1. In vivo, pharmacological FAK inhibition reduces tumor size and increases nuclear FAK localization while decreasing CDK4/6 expression.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yibo Zuo, Jiuyi He, Siying Liu, Ying Xu, Jin Liu, Caixia Qiao, Lichao Zang, Wenhuan Sun, Yukang Yuan, Hongguang Zhang, Xiangjie Chen, Lincong Jin, Ying Miao, Fan Huang, Tengfei Ren, Jun Wang, Feng Qian, Chuanwu Zhu, Wei Zhang, Yaobo Liu, Guoqiang Xu, Feng Ma, Hui Zheng
Summary: This study reveals the importance of LATS1 as a signal transmitter in regulating IFN-Ⅰ signaling activity. Activation of LATS1 promotes antiviral activity mediated by IFN-Ⅰ and controls in vivo IFN-Ⅰ signaling and host antiviral immune response.
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Cell Biology
Kimberly K. Hoi, Wenlong Xia, Ming Ming Wei, Maria Jose Ulloa Navas, Jose-Manuel Garcia Verdugo, Maxence Nachury, Jeremy F. Reiter, Stephen P. J. Fancy
Summary: Remyelination after white matter injury (WMI) often fails in diseases like multiple sclerosis due to improper recruitment and repopulation of oligodendrocyte precursor cells (OPCs) in lesions. Primary cilia play a crucial role in the OPC response to WMI through the GPCR/cAMP/CREB signaling axis.
Article
Biochemistry & Molecular Biology
Luc de Waal, Timothy A. Lewis, Matthew G. Rees, Aviad Tsherniak, Xiaoyun Wu, Peter S. Choi, Lara Gechijian, Christina Hartigan, Patrick W. Faloon, Mark J. Hickey, Nicola Tolliday, Steven A. Carr, Paul A. Clemons, Benito Munoz, Bridget K. Wagner, Alykhan F. Shamji, Angela N. Koehler, Monica Schenone, Alex B. Burgin, Stuart L. Schreiber, Heidi Greulich, Matthew Meyerson
NATURE CHEMICAL BIOLOGY
(2016)
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Chemistry, Medicinal
Chris Dockendorff, Patrick W. Faloon, Miao Yu, Willmen Youngsaye, Marsha Penman, Thomas J. F. Nieland, Partha P. Nag, Timothy A. Lewis, Jun Pu, Melissa Bennion, Joseph Negri, Conor Paterson, Garrett Lam, Sivaraman Dandapani, Jose R. Perez, Benito Munoz, Michelle A. Palmer, Stuart L. Schreiber, Monty Krieger
ACS MEDICINAL CHEMISTRY LETTERS
(2015)
Article
Biology
Zhengjian Zhang, Zarko Boskovic, Mahmud M. Hussain, Wenxin Hu, Carla Inouye, Han-Je Kim, A. Katherine Abole, Mary K. Doud, Timothy A. Lewis, Angela N. Koehler, Stuart L. Schreiber, Robert Tjian
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Biochemistry & Molecular Biology
Zarko V. Boskovic, Melissa M. Kemp, Allyson M. Freedy, Vasanthi S. Viswanathan, Marius S. Pop, Jason H. Fuller, Nicole M. Martinez, Samuel O. Figueroa Lazu, Jiyoung A. Hong, Timothy A. Lewis, Daniel Calarese, James D. Love, Amedeo Vetere, Steven C. Almo, Stuart L. Schreiber, Angela N. Koehler
ACS CHEMICAL BIOLOGY
(2016)
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Biochemistry & Molecular Biology
David B. Sykes, Youmna S. Kfoury, Francois E. Mercier, Mathias J. Wawer, Jason M. Law, Mark K. Haynes, Timothy A. Lewis, Amir Schajnovitz, Esha Jain, Dongjun Lee, Hanna Meyer, Kerry A. Pierce, Nicola J. Tolliday, Anna Waller, Steven J. Ferrara, Ashley L. Eheim, Detlef Stoeckigt, Katrina L. Maxcy, Julien M. Cobert, Jacqueline Bachand, Brian A. Szekely, Siddhartha Mukherjee, Larry A. Sklar, Joanne D. Kotz, Clary B. Clish, Ruslan I. Sadreyev, Paul A. Clemons, Andreas Janzer, Stuart L. Schreiber, David T. Scadden
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Multidisciplinary Sciences
Nobutaka Kato, Eamon Comer, Tomoyo Sakata-Kato, Arvind Sharma, Manmohan Sharma, Micah Maetani, Jessica Bastien, Nicolas M. Brancucci, Joshua A. Bittker, Victoria Corey, David Clarke, Emily R. Derbyshire, Gillian L. Dornan, Sandra Duffy, Sean Eckley, Maurice A. Itoe, Karin M. J. Koolen, Timothy A. Lewis, Ping S. Lui, Amanda K. Lukens, Emily Lund, Sandra March, Elamaran Meibalan, Bennett C. Meier, Jacob A. McPhail, Branko Mitasev, Eli L. Moss, Morgane Sayes, Yvonne Van Gessel, Mathias J. Wawer, Takashi Yoshinaga, Anne-Marie Zeeman, Vicky M. Avery, Sangeeta N. Bhatia, John E. Burke, Flaminia Catteruccia, Jon C. Clardy, Paul A. Clemons, Koen J. Dechering, Jeremy R. Duvall, Michael A. Foley, Fabian Gusovsky, Clemens H. M. Kocken, Matthias Marti, Marshall L. Morningstar, Benito Munoz, Daniel E. Neafsey, Amit Sharma, Elizabeth A. Winzeler, Dyann F. Wirth, Christina A. Scherer, Stuart L. Schreiber
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Biochemistry & Molecular Biology
Cecilia Lopez-Sambrooks, Shiteshu Shrimal, Carol Khodier, Daniel P. Flaherty, Natalie Rinis, Jonathan C. Charest, Ningguo Gao, Peng Zhao, Lance Wells, Timothy A. Lewis, Mark A. Lehrman, Reid Gilmore, Jennifer E. Golden, Joseph N. Contessa
NATURE CHEMICAL BIOLOGY
(2016)
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Chemistry, Medicinal
Timothy A. Lewis, David B. Sykes, Jason M. Law, Benito Munoz, Joane K. Rustiguel, Maria Cristina Nonato, David T. Scadden, Stuart L. Schreiber
ACS MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Biochemistry & Molecular Biology
Mark A. Nakasone, Timothy A. Lewis, Olivier Walker, Anita Thakur, Wissam Mansour, Carlos A. Castaneda, Jennifer L. Goeckeler-Fried, Frank Parlati, Tsui-Fen Chou, Ortal Hayat, Daoning Zhang, Christina M. Camara, Steven M. Bonn, Urszula K. Nowicka, Susan Krueger, Michael H. Glickman, Jeffrey L. Brodsky, Raymond J. Deshaies, David Fushman
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Chemistry, Medicinal
Andrew R. Germain, Leigh C. Carmody, Barbara Morgan, Cristina Fernandez, Erin Forbeck, Timothy A. Lewis, Partha P. Nag, Amal Ting, Lynn VerPlank, Yuxiong Feng, Jose R. Perez, Sivaraman Dandapani, Michelle Palmer, Eric S. Lander, Piyush B. Gupta, Stuart L. Schreiber, Benito Munoz
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2012)
Article
Chemistry, Medicinal
Longqin Hu, Sadagopan Magesh, Lin Chen, Lili Wang, Timothy A. Lewis, Yu Chen, Carol Khodier, Daigo Inoyama, Lesa J. Beamer, Thomas J. Emge, Jian Shen, John E. Kerrigan, Ah-Ng Tony Kong, Sivaraman Dandapani, Michelle Palmer, Stuart L. Schreiber, Benito Munoz
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2013)
Article
Chemistry, Medicinal
Hilaire Playa, Timothy A. Lewis, Amal Ting, Byung-Chul Suh, Benito Munoz, Robert Matuza, Brent J. Passer, Stuart L. Schreiber, John K. Buolamwini
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2014)
Article
Multidisciplinary Sciences
Stefan Kubicek, Joshua C. Gilbert, Dina Fomina-Yadlin, Alexander D. Gitlin, Yuan Yuan, Florence F. Wagner, Edward B. Holson, Tuoping Luo, Timothy A. Lewis, Bradley Taylor, Supriya Gupta, Alykhan F. Shamji, Bridget K. Wagner, Paul A. Clemons, Stuart L. Schreiber
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
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Chemistry, Medicinal
Timothy A. Lewis, Luc de Waal, Xiaoyun Wu, Willmen Youngsaye, Antje Wengner, Charlotte Kopitz, Martin Lange, Stefan Gradl, Manuel Ellermann, Philip Lienau, Stuart L. Schreiber, Heidi Greulich, Matthew Meyerson
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Nicholas B. Struntz, Andrew Chen, Anja Deutzmann, Robert M. Wilson, Eric Stefan, Helen L. Evans, Maricela A. Ramirez, Tong Liang, Francisco Caballero, Mattheus H. E. Wildschut, Dylan V. Neel, David B. Freeman, Marius S. Pop, Marie McConkey, Sandrine Muller, Brice H. Curtin, Hanna Tseng, Kristen R. Frombach, Vincent L. Butty, Stuart S. Levine, Clementine Feau, Sarah Elmiligy, Jiyoung A. Hong, Timothy A. Lewis, Amedeo Vetere, Paul A. Clemons, Scott E. Malstrom, Benjamin L. Ebert, Charles Y. Lin, Dean W. Felsher, Angela N. Koehler
CELL CHEMICAL BIOLOGY
(2019)