The Herpes Simplex Virus 1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8+ T Cells in Latently Infected Trigeminal Ganglia: a Novel Immune Evasion Mechanism

Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions

(2014) K. Nagahara et al.   JOURNAL OF IMMUNOLOGY

The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1

(2011) S. J. Allen et al.   JOURNAL OF VIROLOGY

Nasolacrimal Duct Closure Modulates Ocular Mucosal and Systemic CD4+ T-Cell Responses Induced following Topical Ocular or Intranasal Immunization

(2010) A. A. Chentoufi et al.   Clinical and Vaccine Immunology

HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression

(2010) Bahareh Vali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Future viral vectors for the delivery of asymptomatic herpes epitope-based immunotherapeutic vaccines

(2010) Aziz Alami Chentoufi et al.   Future Virology

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel HLA (HLA-A*0201) Transgenic Rabbit Model for Preclinical Evaluation of Human CD8 + T Cell Epitope-Based Vaccines against Ocular Herpes

(2010) Aziz A. Chentoufi et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Inhibition Is Connected to Exhaustion of CD8+ T Cell Polyfunctionality during Chronic Hepatitis C Virus Infection

(2010) I. G. Rodrigue-Gervais et al.   JOURNAL OF IMMUNOLOGY

Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript

(2010) Gail Henderson et al.   JOURNAL OF NEUROVIROLOGY

The Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Protect Neuron-Derived C1300 and Neuro2A Cells from Granzyme B-Induced Apoptosis and CD8 T-Cell Killing

(2010) X. Jiang et al.   JOURNAL OF VIROLOGY

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New concepts in herpes simplex virus vaccine development: notes from the battlefield

(2009) Gargi Dasgupta et al.   Expert Review of Vaccines

Herpes Simplex Virus Type 1 (HSV-1)-Induced Apoptosis in Human Dendritic Cells as a Result of Downregulation of Cellular FLICE-Inhibitory Protein and Reduced Expression of HSV-1 Antiapoptotic Latency-Associated Transcript Sequences

(2009) A. Kather et al.   JOURNAL OF VIROLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

High antigen levels are the cause of T cell exhaustion during chronic viral infection

(2009) S. N. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

(2008) Sang-Jun Ha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progressive Telomere Shortening of Epstein‐Barr Virus–Specific Memory T Cells during HIV Infection: Contributor to Exhaustion?

(2008) Debbie van Baarle et al.   JOURNAL OF INFECTIOUS DISEASES

Stern−Gerlach Study of Multidecker Lanthanide−Cyclooctatetraene Sandwich Clusters

(2008) Ken Miyajima et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Level of Herpes Simplex Virus Type 1 Latency Correlates with Severity of Corneal Scarring and Exhaustion of CD8+ T Cells in Trigeminal Ganglia of Latently Infected Mice

(2008) K. R. Mott et al.   JOURNAL OF VIROLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Noncytotoxic Lytic Granule-Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

(2008) J. E. Knickelbein et al.   SCIENCE

Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity

(2007) Dale Carpenter et al.   MICROBIAL PATHOGENESIS