Article
Biochemistry & Molecular Biology
Pietro Giuseppe Mazzara, Elena Criscuolo, Marco Rasponi, Luca Massimino, Sharon Muggeo, Cecilia Palma, Matteo Castelli, Massimo Clementi, Roberto Burioni, Nicasio Mancini, Vania Broccoli, Nicola Clementi
Summary: This study has developed a stable and reliable in vitro system that models the connectivity between different human sensory neurons and peripheral tissues. By analyzing the infection process of herpes simplex virus 1 (HSV-1), it provides a better understanding of viral latency and reactivation at the cellular and molecular levels.
Article
Immunology
Michiel van Gent, Werner J. D. Ouwendijk, Victoria L. Campbell, Kerry J. Laing, Georges M. G. M. Verjans, David M. Koelle
Summary: This study suggests that VZV-specific CD8 T-cells play a limited role in maintaining latent infection of varicella-zoster virus in human trigeminal ganglia.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Infectious Diseases
Ying Zhang, Li-Si Zeng, Juan Wang, Wen-Qi Cai, Weiwen Cui, Tong-Jun Song, Xiao-Chun Peng, Zhaowu Ma, Ying Xiang, Shu-Zhong Cui, Hong-Wu Xin
Summary: Latent infection affects HSV reactivation, and deleting LAT reduces the latency and recurrence of the virus, providing new ideas for the future development of therapeutics and vaccines.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Pharmacology & Pharmacy
David I. Bernstein, Nancy M. Sawtell, Fernando J. Bravo, David A. Dixon, Christian Gege, Gerald Kleymann
Summary: The study investigates a treatment method for latent neuronal herpes simplex virus infections. The use of the helicase-primase inhibitor (HPI) IM-250 reduces the reactivation frequency significantly.
ANTIVIRAL RESEARCH
(2023)
Article
Virology
Kati Tormanen, Harry H. Matundan, Shaohui Wang, Ujjaldeep Jaggi, Kevin R. Mott, Homayon Ghiasi
Summary: This study reveals that the small noncoding RNA1 (sncRNA1) encoded within HSV-1 latency-associated transcript (LAT) plays a protective role during acute ocular infection by modulating the innate immune response. Deletion of sncRNA1 reduces the levels of certain genes and alters immune pathways, but does not affect latency or reactivation of the virus.
JOURNAL OF VIROLOGY
(2022)
Review
Immunology
Thanayod Sasivimolrattana, Parvapan Bhattarakosol
Summary: Herpes simplex virus type 1 (HSV-1) is a common viral pathogen that can infect various parts of the body, leading to diverse clinical manifestations. In addition to infecting fibroblast, epithelial, mucosal cells, and neurons, HSV-1 can also infect activated T lymphocyte cells. Actin polymerization and filopodia formation have been found to support HSV-1 infection in different cell types. This review explores the mechanism of HSV-1 infection in various cell types, focusing on filopodia formation, and discusses potential future directions for HSV-1 entry-related research. Moreover, it provides insights into possible therapeutic interventions targeting the entry step of HSV-1.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Letter
Ophthalmology
Nan Chen, Dong Chen, Jun Cheng
Summary: This case report describes a patient who experienced herpes simplex virus (HSV)-related inflammation in the cornea and retina over a period of more than two decades. The patient underwent penetrating keratoplasty for HSV stromal keratitis in 2004 and vitrectomy for acute retinal necrosis (ARN) in 2021. The viruses remained dormant after keratoplasty for 17 years until reactivation occurred and triggered ARN. One year later, the patient developed HSV epithelial keratitis, but the cornea regained transparency after medical treatment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Immunology
Jonathan D. Joyce, Anant K. Patel, Brandie Murphy, Daniel J. J. Carr, Edward Gershburg, Andrea S. Bertke
Summary: The study showed that the two novel live-attenuated HSV-2 vaccine candidates are safe in guinea pigs and do not establish latency in neural ganglia. In contrast, wild-type HSV-2 resulted in acute disease and latent infection in neural ganglia. Both vaccine candidates elicited neutralizing antibodies.
Article
Microbiology
Ujjaldeep Jaggi, Harry H. Matundan, Jack Yu, Satoshi Hirose, Mathias Mueller, Floyd L. Wormley Jr, Homayon Ghiasi
Summary: The study highlights the importance of M1 macrophages in primary HSV-1 infection, eye disease, and survival, while not affecting latency-reactivation. Mice lacking M1 activation are more susceptible to HSV-1 infection and have higher virus titers in the eye. Additionally, the absence of M1 macrophages leads to significantly higher inflammatory responses and cytokine storm in the eyes of infected mice.
Article
Neurosciences
Karrar Mahmood Shaker AL-Khfaji, Nika Kooshki Zamani, Ehsan Arefian
Summary: This study identified miRNAs encoding LAT that may target the important genes STXBP1 and GABBR2 in the GABAergic pathway. Experimental results showed that overexpression of miR-H3 and miR-H4 significantly decreased the expression levels of STXBP1 and GABBR2. However, the LAT transcript had no significant effect on the regulation of the GABBR2 gene.
JOURNAL OF NEUROVIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan Yao, Juxian Gu, Meng Li, Guoce Li, Li Zhao, Jingyi Ai
Summary: The research aimed to analyze the MRI changes and expression of neuron-specific enolase (NSE) and monocyte chemoattractant protein-1 (MCP-1) in the cerebrospinal fluid (CSF) of patients with severe herpes simplex encephalitis. The results showed that the expression of NSE and MCP-1 in the CSF increased significantly in the study group compared to the control group, and there was a positive correlation between NSE and MCP-1. These findings have important value in the early diagnosis of severe herpes simplex encephalitis.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Neurosciences
Liza Lind, Alexandra Svensson, Karolina Thorn, Malgorzata Krzyzowska, Kristina Eriksson
Summary: The study revealed that during herpesvirus neuroinflammation, anti-viral CD8(+) T cells accumulate in the central nervous system, particularly in the spinal cord, displaying high activation levels and expressing chemotactic receptors corresponding to chemotactic gradients present in the tissue.
JOURNAL OF NEUROVIROLOGY
(2021)
Article
Ophthalmology
Guey-Chuen Perng, Nelson Osorio, Xianzhi Jiang, Roger Geertsema, Chinhui Hsiang, Don Brown, Lbachir BenMohamed, Steven L. Wechsler
CURRENT EYE RESEARCH
(2016)
Article
Multidisciplinary Sciences
Xian-Zhi Jiang, Zhong-Dong Yu, Yong-Ming Ruan, Long Wang
SCIENTIFIC REPORTS
(2018)
Article
Evolutionary Biology
Yong-Zhao Diao, Qian Chen, Xian-Zhi Jiang, Jos Houbraken, Renan N. Barbosa, Lei Cai, Wen-Ping Wu
Article
Mycology
Wenjiao Cai, Panpan Huang, Ying Yan, Bingda Sun, Xianzhi Jiang, Amanda J. Chen
Article
Mycology
Panpan Huang, Xianzhi Jiang, Bing Wu, Jingzu Sun
Article
Plant Sciences
Bing-Da Sun, Pan-Pan Huang, Hai-Lei Wei, Wen-Jiao Cai, Lin Wang, Shen-Kun Liu, Xian-Zhi Jiang, Amanda-Juan Chen
Article
Mycology
Bing-Da Sun, Amanda J. Chen, Jos Houbraken, Jens C. Frisvad, Wen-Ping Wu, Hai-Lei Wei, Yu-Guang Zhou, Xian-Zhi Jiang, Robert A. Samson
Article
Microbiology
Bing Da Sun, Jos Houbraken, Jens C. Frisvad, Xian Zhi Jiang, Amanda Juan Chen, Robert A. Samson
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Engineering, Environmental
Daiyang Xia, Lin Yang, Yu Li, Jianying Chen, Xiufen Zhang, Heng Wang, Shuangshuang Zhai, Xianzhi Jiang, Giuseppe Meca, Shunxiang Wang, Liang Huang, Shanshan Zhu, Yang Fu, Weiqing Ma, Yongwen Zhu, Hui Ye, Wence Wang
Summary: Melatonin (MEL) exhibits anti-inflammatory effects and regulates intestinal microbiota in OTA-induced liver inflammation, showing promise as a protective approach for mycotoxins like OTA.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Meeting Abstract
Oncology
Chuan-Sheng Lin, Xianzhi Jiang, Baoxia Li, Yibo Xian, Xue Su, Zhenzhen Liu, Jiening Liang, Yingying Zhao, Qianying Deng, Baojia Huang, Tengxun Zhang, Ruijuan Zhu, Yajun Liang, Zhengjiao Liang, Chen Xiao, Zupeng Kuang, Guozhen Zhao
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Veterinary Sciences
Weiqing Ma, Lingjuan Zhou, Yu Li, Daiyang Xia, Jianying Chen, Junpeng Chen, Xianzhi Jiang, Jiangfan Qin, Yujie Zhao, Xiufen Zhang, Heng Wang, Yang Fu, Shanshan Zhu, Huiquan Jiang, Hui Ye, Yongwen Zhu, Zhenping Lin, Wence Wang, Lin Yang
Summary: The study found that purine metabolic abnormalities caused by a high-calcium, high-protein diet led to liver and kidney damage in geese, resulting in hyperuricemia and gout symptoms, while also impairing the intestinal barrier and disrupting the intestinal flora.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Nutrition & Dietetics
Daiyang Xia, Lin Yang, Jiajie Cui, Yu Li, Xianzhi Jiang, Giuseppe Meca, Shunxiang Wang, Yan Feng, Yujie Zhao, Jiangfan Qin, Yongwen Zhu, Hui Ye, Wence Wang
Summary: Exposure to blue light in Cherry Valley ducks led to decreased body weight and feed intake, but increased leg muscle and relative length of the intestine. Blue light enhanced anti-inflammatory and antioxidant capacities while reducing lipid levels. Metabolomic analysis revealed changes in cysteine and methionine metabolism, as well as increased bile acid levels and up-regulation of certain metabolites. Intestinal microbiota diversity and relative abundances of beneficial bacteria were increased, leading to enhanced lipid metabolism and reduced cholesterol levels.
FRONTIERS IN NUTRITION
(2021)
Article
Energy & Fuels
Haipeng Pan, Zhongqian Yin, Xianzhi Jiang
Summary: This study presents a high-dimensional energy consumption anomaly detection method based on deep learning, which can assist building managers in identifying abnormal electricity usage behavior of users. Additionally, users can also utilize the system to understand their own electricity consumption and reduce energy waste.
Article
Microbiology
Bingda Sun, Chunling Luo, Gerald F. Bills, Jibing Li, Panpan Huang, Lin Wang, Xianzhi Jiang, Amanda Juan Chen
Summary: This study identified four new species in the subgenus Nidulantes of the Aspergillus genus, based on sampling agricultural soils from various regions in China. The morphological descriptions and genetic analysis confirmed the presence of these new species.
Article
Biotechnology & Applied Microbiology
Zhengyang Zhao, Lin Wang, Raja Asad Ali Khan, Xiaojun Song, Saba Najeeb, Jianlong Zhao, Yuhong Yang, Jian Ling, Zhenchuan Mao, Xianzhi Jiang, Bingyan Xie, Yan Li
Summary: The biocontrol potential of Methylorubrum rhodesianum M520 against Meloidogyne incognita was investigated, and the results showed that M520 has significant effects on the mortality of the nematode and promotes plant growth. Therefore, M520 has the potential to be used as a biocontrol agent against RKNs.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)