Article
Biochemistry & Molecular Biology
Alicia Weier, Michael Enders, Philipp Kirchner, Arif Ekici, Marc Bigaud, Christopher Kapitza, Juergen Woerl, Stefanie Kuerten
Summary: Multiple sclerosis is an autoimmune disease of the central nervous system. Siponimod, the only approved drug for secondary progressive MS, acts on the peripheral immune system and does not have pronounced direct neuroprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Shehla U. Hridi, Mark Barbour, Chelsey Wilson, Aimee Jpm Franssen, Tanith Harte, Trevor J. Bushell, Hui-Rong Jiang
Summary: Interleukin-16 is closely involved in the pathology of multiple sclerosis and other inflammatory diseases in the central nervous system by being produced by glial and infiltrating immune cells, impacting the recruitment and activation of CD4(+) immune cells in neuroinflammation.
Review
Virology
Ivanildo P. Sousa Jr, Flavia B. dos Santos, Vanessa S. de Paula, Tuane C. R. G. Vieira, Helver G. Dias, Caroline A. Barros, Edson E. da Silva
Summary: Virus-induced infections of the central nervous system pose serious public health problems, especially in low- and middle-income countries. Common viruses include herpes simplex virus and varicella-zoster virus. More research is needed, particularly in countries like Brazil, to better understand the most common viruses involved in CNS infections.
Review
Cell Biology
Di Wu, Dahai Liu, Kensuke Tateishi, Fei Qi, Fang Yang, Chao Ke, Hua You
Summary: This review article presents the phenotypic and genotypic features of primary central nervous system lymphoma (PCNSL) tumor cells, and compiles the preclinical animal models of PCNSL. Researchers hope that these animal models will enhance the understanding of the molecular pathogenesis of PCNSL and accelerate the development of novel therapeutic strategies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Microbiology
Ana Borrajo, Valentina Svicher, Romina Salpini, Michele Pellegrino, Stefano Aquaro
Summary: Chronic infection of HIV-1 leads to serious CD4+ T cell immunodeficiency and neurocognitive disorders in the central nervous system, contributing to increasing morbidity and mortality globally. Despite advancements in treatment, there is still incomplete understanding of the pathogenesis and role of inflammation in neurodegenerative difficulties.
Review
Multidisciplinary Sciences
Justin Rustenhoven, Jonathan Kipnis
Summary: The concept of immune privilege suggests that the central nervous system is isolated from the immune system, but recent studies have identified the central nervous system borders as central sites for neuro-immune interactions. Both the nervous and immune systems function to maintain homeostasis, but under rare circumstances, they can develop pathological interactions that result in neurological or psychiatric diseases. This article discusses the recent findings on the anatomical, cellular, and molecular mechanisms that enable neuro-immune responses at the borders of the brain and spinal cord, and the implications of these interactions for diseases of the central nervous system.
Article
Audiology & Speech-Language Pathology
Ningning Shao, Shangyuan Jiang, Daniel Younger, Tao Chen, Marcus Brown, Kakulavarapu V. Rama Rao, Maciej Skotak, Rong Z. Gan, Namas Chandra
Summary: This study investigated the changes in both peripheral and central auditory systems after exposure to blast overpressure, revealing that earplugs can protect against structural damage but provide limited protection for hearing levels and central auditory system. Indicating that central auditory dysfunction may be mediated by shockwave transmission in various regions of the central nervous system. Targeting central auditory neurotransmitter abnormalities could potentially attenuate blast-induced hearing loss and tinnitus.
Article
Virology
Jun Liu, Hongwei Zhao, Ziheng Feng, Yingchao Liu, Qianyu Feng, Suyun Qian, Lili Xu, Hengmiao Gao, Zhengde Xie
Summary: This article reports a severe case of rhinovirus infection, which is most likely responsible for the patient's central nervous system symptoms and viral sepsis.
Review
Immunology
Zachary Van Roy, Tammy Kielian
Summary: Epigenetics focuses on adaptable transcriptional regulation, influencing cell identity and function. During CNS infection, epigenetic mechanisms play a significant role in controlling immune cell maturation and antimicrobial properties. Researchers use epigenetic marks to organize immune cell populations' activation states and inflammatory processes in response to CNS infection.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Carolina Prado, Francisco Osorio-Barrios, Paulina Falcon, Alexandra Espinoza, Juan Jose Saez, Maria Isabel Yuseff, Rodrigo Pacheco
Summary: Recent evidence has shown dopamine as a major regulator of inflammation, with dopaminergic regulation of immune cells playing an important role in inflammatory disorders. The study addressed the role of dopamine receptor D3 in B cells in animal models of multiple sclerosis (MS) and found that selective Drd3 deficiency in B cells abolished disease development in one model while exacerbating disease severity in another, demonstrating a dual role of DRD3 in CNS-autoimmunity.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Han-Yu Cao, Hui Chen, Song-Bai Liu, Wen-Jie Gong, Chong-Sheng Qian, Tong-Tong Zhang, Chao-Ling Wan, Si-Man Huang, Nan Xu, Hai-Ping Dai, Sheng-Li Xue
Summary: The treatment of B-cell acute lymphoblastic leukemia (B-ALL) with central nervous system (CNS) involvement is challenging due to weak permeability of chemotherapeutic agents to the blood-brain barrier (BBB) and potential complications of current anti-CNS leukemia treatments. Immunotherapy, particularly blinatumomab, shows potential in treating CNS leukemia with both cerebral spinal fluid and cerebral parenchymal involvement, but further studies are needed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Derek J. Bangs, Alexandra Tsitsiklis, Zoe Steier, Shiao Wei Chan, James Kaminski, Aaron Streets, Nir Yosef, Ellen A. Robey
Summary: Effector CD8+ T cell production during persistent infection requires a stable pool of stem-like cells. Infection models of T cell exhaustion can induce this process through checkpoint blockade, but it occurs spontaneously in mice with chronic Toxoplasma gondii infection. The specific locations of parasite-specific T cell subsets in the spleen imply a connection between differentiation and anatomical niches. Loss of CXCR3 on T cells does not prevent migration but reduces interactions with dendritic cells (DCs) producing CXCR3 ligands and impairs memory-to-intermediate transition, resulting in an accumulation of memory T cells in the spleen. Therefore, CXCR3 increases T cell exposure to differentiation-inducing signals during migration, providing a dynamic mechanism to modulate effector differentiation in response to environmental signals.
Article
Chemistry, Analytical
Yunyun Hu, Ye Tian, Haonan Di, Chengfeng Xue, Yanping Zheng, Bin Hu, Qin Lin, Xiaomei Yan
Summary: This study utilized nanoflow cytometry to examine surface proteins on extracellular vesicles and found that EVSUM5 and EVSUM2 can effectively differentiate NPC patients from NPG patients, providing a more accurate diagnostic method.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Louise A. Mesentier-Louro, Barbara Rangel, Laurel Stell, M. Ali Shariati, Roopa Dalal, Abinaya Nathan, Ke Yuan, Vinicio de Jesus Perez, Yaping Joyce Liao
Summary: The study revealed that systemic hypoxia can lead to retinal edema and inflammation, which in turn cause visual disturbances. Results showed a significant increase in immune factors in plasma and retina within 1 hour after hypoxia, along with notable changes in retinal tissue. These inflammatory responses rapidly improved within 24 hours, consistent with the typically mild and transient visual disturbances associated with hypoxia.
Article
Immunology
Akari Nishida, Rina Ikeda, Hidefumi Furuoka, Yoshifumi Nishikawa
Summary: This study found that CXCR3-deficient mice showed significant fetal loss after T. gondii infection in early pregnancy. The embryos of infected mice exhibited necrosis, with a significant increase in embryo resorption in CXCR3(-/-) mice, indicating that CXCR3-dependent immune responses provide anti-Toxoplasma activity and reduce embryo resorption and fetal loss caused by T. gondii infection during early pregnancy.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Shengbo Zhang, Hannah D. Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J. Kueh, Daniel Brown, Wang Cao, Nicolas Jacquelot, Angela D'Amico, Andrew M. Lew, Yifan Zhan, Christopher J. Tonkin, Jose A. Villadangos, Gordon K. Smyth, Michael Chopin, Stephen L. Nutt
Summary: The transcription factor DC-SCRIPT plays a critical role in the development and function of conventional dendritic cells (cDC1), with its deficiency leading to impaired antigen capture and presentation capabilities. This study highlights the importance of DC-SCRIPT in maintaining the identity and functional attributes of cDC1s.
SCIENCE IMMUNOLOGY
(2021)
Review
Immunology
Stephanie Trezise, Stephen L. Nutt
Summary: This review discusses the gene regulatory network that controls ASC identity and function, with a focus on the processes influencing antibody transcription, translation, folding, modification, and secretion. It also addresses how ASCs have adapted their pathways to sustain high rates of antibody production and the roles of major ASC regulators in coordinating these processes.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Jacob T. Jackson, Elisabeth Mulazzani, Stephen L. Nutt, Seth L. Masters
Summary: PLC gamma 2 is a crucial signaling molecule downstream from cell surface receptors, its dysfunction associated with various diseases. Variants in PLC gamma 2 exhibit diverse pathologies, offering potential for therapeutic manipulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Immunology
Samuel A. Rose, Aleksandra Wroblewska, Maxime Dhainaut, Hideyuki Yoshida, Jonathan M. Shaffer, Anela Bektesevic, Benjamin Ben-Zvi, Andrew Rhoads, Edy Y. Kim, Bingfei Yu, Yonit Lavin, Miriam Merad, Jason D. Buenrostro, Brian D. Brown
Summary: The study generated an atlas of miRNA expression profiles from primary mouse immune cell populations and connected these signatures with ATAC-seq, ChIP-seq, and nascent RNA profiles to establish a map of miRNA promoter and enhancer usage in immune cells.
Article
Immunology
Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A. de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L. Nutt, Viktor Umansky, Bogoljub Ciric, Joanna R. Groom, Paul S. Foster, Philip M. Hansbro, Andrew N. J. McKenzie, Daniel H. D. Gray, Andreas Behren, Jonathan Cebon, Eric Vivier, Ian P. Wicks, Joseph A. Trapani, Ariel Munitz, Melissa J. Davis, Wei Shi, Paul J. Neeson, Gabrielle T. Belz
Summary: ILC2s play a critical role in melanoma immunity by producing cytokines that enhance antitumor responses. High infiltration of ILC2s in melanoma is associated with good clinical prognosis, but their antitumor functions may be restricted by programmed cell death protein-1.
Article
Immunology
Yifan Zhan, Yuxia Zhang, Shengbo Zhang, Hannah Coughlan, Pedro L. Baldoni, Nicolas Jacquelot, Wang H. J. Cao, Simon Preston, Cynthia Louis, Jai Rautela, Marc Pellegrini, Ian P. Wicks, Warren S. Alexander, Leonard C. Harrison, Andrew M. Lew, Gordon K. Smyth, Stephen L. Nutt, Michael Chopin
Summary: The study found that selectively deleting core components of PRC2, either EZH2 or SUZ12, in CD11c-expressing myeloid cells had different effects on H3K27me3. While EZH2 deficiency did not affect the deposition and maintenance of H3K27me3 in DCs or hinder DC/macrophage homeostasis, SUZ12 deficiency significantly impacted the ability of DCs and macrophages to maintain H3K27me3. This suggests fundamentally different homeostatic mechanisms for tissue-resident myeloid cells versus DCs.
SCIENCE IMMUNOLOGY
(2021)
Article
Cell Biology
Elise Clayer, Daniel Frank, Holly Anderton, Shengbo Zhang, Andrew Kueh, Valentin Heim, Stephen L. Nutt, Michael Chopin, Philippe Bouillet
Summary: The role of CCCH-containing RNA-binding proteins in regulating inflammation is important. ZC3H12C is identified as a potential post-transcriptional regulator of tumor necrosis factor expression. ZC3H12C depletion in dendritic cells causes lymphadenopathy, but it does not significantly impact skin inflammation.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Editorial Material
Cell Biology
Stephen L. Nutt, Michael Chopin
Summary: Researchers have identified a new population of type 2 conventional dendritic cells in the skin that rely on IL-13 and promote Th2-mediated immunity.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Cell Biology
Lennard Dalit, Carolina Alvarado, Lisan Kuijper, Andrew J. Kueh, Ashley Weir, Angela D'Amico, Marco J. Herold, James E. Vince, Stephen L. Nutt, Joanna R. Groom
Summary: The chemokine receptor CXCR3 is expressed on immune cells to coordinate lymphocyte activation and migration. Its ligands CXCL9, CXCL10, and CXCL11 have distinct roles during viral infection. Using CRISPR/Cas9, mutations in CXCL11 were corrected in C57BL/6 mice, providing a new tool to study the function of CXCL11 in experimental settings.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Hema Preethi Subas Satish, Kathleen Zeglinski, Rachel T. Uren, Stephen L. Nutt, Matthew E. Ritchie, Quentin Gouil, Ruth M. Kluck
Summary: Despite their common use in research, monoclonal antibodies are not systematically sequenced. Researchers developed a three-day, cost-effective workflow called NAb-seq using long-read ONT sequencing to characterize monoclonal antibody genes from hybridoma cell lines and single cells. This method shows high accuracy, reliability, and scalability compared to traditional Sanger sequencing.
Article
Multidisciplinary Sciences
Ashleigh R. Poh, Christopher G. Love, David Chisanga, James H. Steer, David Baloyan, Michael Chopin, Stephen Nutt, Jai Rautela, Nicholas D. Huntington, Nima Etemadi, Megan O'Brien, Ryan O'Keefe, Lesley G. Ellies, Christophe Macri, Justine D. Mintern, Lachlan Whitehead, Gangadhara Gangadhara, Louis Boon, Ashwini L. Chand, Clifford A. Lowell, Wei Shi, Fiona J. Pixley, Matthias Ernst
Summary: Genetic ablation or therapeutic inhibition of the myeloid-specific hematopoietic cell kinase (HCK) enhances the response to immunotherapy by modifying the tumor microenvironment and promoting immune cell activation.
Review
Immunology
Amber Cardani-Boulton, Brendan T. Boylan, Volodymyr Stetsenko, Cornelia C. Bergmann
Summary: A diverse range of DNA and RNA viruses can invade the central nervous system (CNS) and cause inflammation and injury to cells with limited repair and regeneration capabilities. Although rare, viral encephalitis in humans is often fatal, and survivors can experience permanent neurological sequelae, including seizures. Current treatment options are limited, primarily relying on vaccines, antivirals, or supportive care. Many viral CNS infections are characterized by the presence of antiviral antibodies in the cerebral spinal fluid (CSF), indicating local maintenance of protective antibody-secreting cells. However, the mechanisms underlying these humoral responses are poorly understood.
IMMUNOLOGICAL REVIEWS
(2022)
Editorial Material
Immunology
Julie Tellier, Stephen L. Nutt
Article
Oncology
N. Jacquelot, J. Tellier, S. L. Nutt, G. T. Belz
Summary: Tertiary lymphoid structures (TLS) are ectopic cellular aggregates resembling secondary lymphoid organs. Found in solid tumors, TLS exhibit varying degrees of maturation and are composed of diverse immune cell types that actively drive the immune response against tumor development and progression. Their role, prognostic value, and potential for immunotherapeutic targeting are discussed in this review.
Article
Oncology
Pasquale L. Fedele, Yang Liao, Jia-nan Gong, Yuan Yao, Mark F. van Delft, Michael S. Y. Low, Lin Tai, Marco J. Herold, Jacob T. Jackson, Charis E. Teh, Tania Tan, Lorraine A. O'Reilly, Julie Tellier, George Grigoriadis, David C. S. Huang, Wei Shi, Stephen L. Nutt, Simon N. Willis