Article
Biochemistry & Molecular Biology
Fanghui Ren, Ryo Narita, Ahmad S. Rashidi, Stefanie Fruhwurth, Zongliang Gao, Rasmus O. Bak, Martin K. Thomsen, Georges M. G. M. Verjans, Line S. Reinert, Soren R. Paludan
Summary: Neurotropic viruses such as herpes simplex virus (HSV) can infect neurons and cause severe diseases. HSV-induced neuronal cell death is mediated by gasdermin E (GSDME) and involves endoplasmic reticulum stress, caspase activation, and mitochondria-dependent apoptosis. The necrotic neurons release alarmins, triggering inflammatory responses in microglia.
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Biochemistry & Molecular Biology
Pietro Giuseppe Mazzara, Elena Criscuolo, Marco Rasponi, Luca Massimino, Sharon Muggeo, Cecilia Palma, Matteo Castelli, Massimo Clementi, Roberto Burioni, Nicasio Mancini, Vania Broccoli, Nicola Clementi
Summary: This study has developed a stable and reliable in vitro system that models the connectivity between different human sensory neurons and peripheral tissues. By analyzing the infection process of herpes simplex virus 1 (HSV-1), it provides a better understanding of viral latency and reactivation at the cellular and molecular levels.
Article
Microbiology
Fujun Hou, Zeyu Sun, Yue Deng, Siyu Chen, Xiyuan Yang, Feiyang Ji, Menghao Zhou, Keyi Ren, Dongli Pan
Summary: This study investigates the targets of ICP0 in HSV-1 infection and its roles in neuronal cells. Mass spectrometry analysis identified various proteins interacting with ICP0 in Neuro-2a and 293T cells. Further experiments confirmed that SNX9 and OTUD4 restrict the replication of ICP0-null virus in neuronal cells, and OTUD4 enhances the expression of type I interferon during infection with ICP0-null virus.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Jolien Van Cleemput, Orkide O. Koyuncu, Kathlyn Laval, Esteban A. Engel, Lynn W. Enquist
Summary: The study reveals the potential indirect role of tegument protein UL13 in promoting productive infection by phosphorylating other tegument proteins, suggesting its involvement in escape from genome silencing and initiation of productive infection in neurons.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Michiel van Gent, Werner J. D. Ouwendijk, Victoria L. Campbell, Kerry J. Laing, Georges M. G. M. Verjans, David M. Koelle
Summary: This study suggests that VZV-specific CD8 T-cells play a limited role in maintaining latent infection of varicella-zoster virus in human trigeminal ganglia.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Jingjing Zhang, Xingli Xu, Suqin Duan, Yang Gao, Danjing Ma, Rong Yue, Fengyuan Zeng, Xueqi Li, Ziyan Meng, Xinghang Li, Zhenye Niu, Guorun Jiang, Li Yu, Yun Liao, Dandan Li, Lichun Wang, Heng Zhao, Ying Zhang, Qihan Li
Summary: This study revealed the strategy of how HSV-1 infection of dendritic cells interferes with the immune system, by investigating the impact of virus infection on both innate and adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Pratima Krishna Suvas, Mizumi Setia, Mashidur Rana, Anish Chakraborty, Susmit Suvas
Summary: This study aimed to characterize CXCR4-expressing cells in uninfected and herpes simplex virus-1 (HSV-1) infected corneas. The expression of CXCR4 and CXCL12 transcripts in uninfected and HSV-1-infected corneas was detected using RT-qPCR assay. Immunofluorescence staining and flow cytometry assay were used to characterize the CXCR4-expressing cells in the corneas.
Article
Clinical Neurology
Diana N. Tran, Amy T. C. M. Bakx, Vera Dis, Eleonora Aronica, Robert M. Verdijk, Werner J. D. Ouwendijk
Summary: The findings suggest that latent or lytic HSV infection in human neurons is not directly associated with aberrant A beta or pTau protein expression. Some aging-related abnormalities were observed in the brains of HSE patients, but they were not limited to HSV-infected cells or brain regions.
Article
Infectious Diseases
Sarah H. Brown, Vanessa A. R. States, Abaseen K. Afghan, Gowri Satyanarayana
Summary: This is a case of a 65-year-old female patient with a history of acute myelogenous leukemia and buccal squamous cell carcinoma, who underwent peripheral blood stem cell transplant and was found to have HSV-1-infected cancer cells on histopathological examination and was treated with valacyclovir.
BMC INFECTIOUS DISEASES
(2022)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Rahul K. Suryawanshi, Chandrashekhar D. Patil, Alex Agelidis, Raghuram Koganti, Tejabhiram Yadavalli, Joshua M. Ames, Hemant Borase, Deepak Shukla
Summary: This study found that compared to animals lacking HPSE, wild-type mice exhibit notable pathophysiology during HSV-1 reinfection. HPSE promotes infected cell survival and supports the formation of a pro-disease environment. In contrast, lack of HPSE enhances intrinsic immunity by promoting cytokine expression, inducing necroptosis of infected cells, and decreasing leukocyte infiltration into the cornea. Overall, recent prior infection immunity fails to abolish disease manifestation during HSV-1 reinfection unless HPSE is rendered inactive.
Article
Immunology
Christopher M. Pruitt, Lise E. Nigrovic, Stephen B. Freedman, Stuart A. Bradin, Sarah J. Curtis, Todd W. Lyons, Aaron S. Miller, Pamela J. Okada, Suzanne M. Schmidt, David Schnadower, Joanna E. Thomson, Andrea T. Cruz
Summary: Despite clear testing recommendations, there is a lack of comprehensive HSV testing in infants. A study of 112 infants with confirmed HSV disease from 23 research centers found that less than one-fifth of the infants underwent all recommended testing, emphasizing the need for increased awareness and adherence to testing recommendations for this vulnerable population.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Infectious Diseases
Ying Zhang, Li-Si Zeng, Juan Wang, Wen-Qi Cai, Weiwen Cui, Tong-Jun Song, Xiao-Chun Peng, Zhaowu Ma, Ying Xiang, Shu-Zhong Cui, Hong-Wu Xin
Summary: Latent infection affects HSV reactivation, and deleting LAT reduces the latency and recurrence of the virus, providing new ideas for the future development of therapeutics and vaccines.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
B. Grubor-Bauk, W. Yu, D. Wijesundara, J. Gummow, T. Garrod, A. J. Brennan, I. Voskoboinik, E. J. Gowans
Article
Multidisciplinary Sciences
Danushka K. Wijesundara, Wenbo Yu, Ben J. C. Quah, Preethi Eldi, John D. Hayball, Kerrilyn R. Diener, Ilia Voskoboinik, Eric J. Gowans, Branka Grubor-Bauk
SCIENTIFIC REPORTS
(2017)
Review
Microbiology
Danushka K. Wijesundara, Charani Ranasinghe, Branka Grubor-Bauk, Eric J. Gowans
FRONTIERS IN MICROBIOLOGY
(2017)
Review
Microbiology
Makutiro Ghislain Masavuli, Danushka K. Wijesundara, Joseph Torresi, Eric J. Gowans, Branka Grubor-Bauk
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Virology
Danushka K. Wijesundara, Jason Gummow, Yanrui Li, Wenbo Yu, Benjamin J. Quah, Charani Ranasinghe, Joseph Torresi, Eric J. Gowans, Branka Grubor-Bauk
JOURNAL OF VIROLOGY
(2018)
Article
Immunology
Dale Christiansen, Linda Earnest-Silveira, Brendon Chua, Irene Boo, Heidi E. Drummer, Branka Grubor-Bauk, Eric J. Gowans, David C. Jackson, Joseph Torresi
Article
Multidisciplinary Sciences
D. Christiansen, L. Earnest-Silveira, B. Chua, P. Meuleman, I. Boo, B. Grubor-Bauk, D. C. Jackson, Z. Y. Keck, S. K. H. Foung, H. E. Drummer, E. J. Gowans, J. Torresi
SCIENTIFIC REPORTS
(2018)
Article
Immunology
S. Roy, M. Jaeson, Z. Li, S. Mahboob, R. J. Jackson, B. Grubor-Bauk, D. K. Wijesundara, E. J. Gowans, C. Ranasinghe
Review
Immunology
Zelalem A. Mekonnen, Branka Grubor-Bauk, Makutiro G. Masavuli, Ashish C. Shrestha, Charani Ranasinghe, Rowena A. Bull, Andrew R. Lloyd, Eric J. Gowans, Danushka K. Wijesundara
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Virology
Zelalem A. Mekonnen, Branka Grubor-Bauk, Kieran English, Preston Leung, Makutiro G. Masavuli, Ashish C. Shrestha, Patrick Bertolino, David G. Bowen, Andrew R. Lloyd, Eric J. Gowans, Danushka K. Wijesundara
JOURNAL OF VIROLOGY
(2019)
Article
Multidisciplinary Sciences
D. Christiansen, L. Earnest-Silveira, B. Grubor-Bauk, D. K. Wijesundara, I. Boo, P. A. Ramsland, E. Vincan, H. E. Drummer, E. J. Gowans, J. Torresi
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Makutiro Ghislain Masavuli, Danushka K. Wijesundara, Alexander Underwood, Dale Christiansen, Linda Earnest-Silveira, Rowena Bull, Joseph Torresi, Eric J. Gowans, Branka Grubor-Bauk
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Immunology
Ashish C. Shrestha, Danushka K. Wijesundara, Makutiro G. Masavuli, Zelalem A. Mekonnen, Eric J. Gowans, Branka Grubor-Bauk
Article
Multidisciplinary Sciences
B. Grubor-Bauk, D. K. Wijesundara, M. Masavuli, P. Abbink, R. L. Peterson, N. A. Prow, R. A. Larocca, Z. A. Mekonnen, A. Shrestha, N. S. Eyre, M. R. Beard, J. Gummow, J. Carr, S. A. Robertson, J. D. Hayball, D. H. Barouch, E. J. Gowans
Article
Biochemistry & Molecular Biology
Kevin Fenix, Danushka K. Wijesundara, Allison J. Cowin, Branka Grubor-Bauk, Zlatko Kopecki
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)