期刊
SCIENCE ADVANCES
卷 5, 期 12, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aax2388
关键词
-
资金
- National Foundation for Medical Research and Innovation (NFMRI), Australia [274]
- Hospital Research Foundation, Australia
- Hospital Research Foundation (THRF
- Australia)
- University of Adelaide Postgraduate Award (Australia)
- International Postgraduate Research Scholarship (IPRS
- Australia)
- Australian Postgraduate Award (APA
- Australia)
The causal association of Zika virus (ZIKV) with microcephaly, congenital malformations in infants, and Guillain-Barre syndrome in adults highlights the need for effective vaccines. Thus far, efforts to develop ZIKV vaccines have focused on the viral envelope. ZIKV NS1 as a vaccine immunogen has not been fully explored, although it can circumvent the risk of antibody-dependent enhancement of ZIKV infection, associated with envelope antibodies. Here, we describe a novel DNA vaccine encoding a secreted ZIKV NS1, that confers rapid protection from systemic ZIKV infection in immunocompetent mice. We identify novel NS1 T cell epitopes in vivo and show that functional NS1-specific T cell responses are critical for protection against ZIKV infection. We demonstrate that vaccine-induced anti-NS1 antibodies fail to confer protection in the absence of a functional T cell response. This highlights the importance of using NS1 as a target for T cell-based ZIKV vaccines.
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