Article
Immunology
Yoshiaki Kanno, Trang Thi Thu Hau, Rise Kurokawa, Takushi Nomura, Masako Nishizawa, Tetsuro Matano, Hiroyuki Yamamoto
Summary: The study showed that passive infusion of neutralizing antibodies during acute infection can enhance broad T-cell responses and lead to robust SIV control in long-term, suggesting the importance of understanding metabolic markers in NAb/T-cell synergy-based HIV/SIV control.
Article
Immunology
Luis Romero-Martin, Ferran Tarres-Freixas, Nuria Pedreno-Lopez, Maria L. Rodriguez de la Concepcion, Francesc Cunyat, Dennis Hartigan-O'Connor, Jorge Carrillo, Beatriz Mothe, Julia Blanco, Marta Ruiz-Riol, Christian Brander, Alex Olvera
Summary: T cell responses, particularly CD8(+) T cell responses, play a critical role in controlling HIV infection. CD8(+) T cell responses are associated with antibody isotype class switching and antibody-dependent cell cytotoxicity, which contribute to effective virus control in HIV controllers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Liping Zhong, Wei Shi, Lu Gan, Xiuli Liu, Yu Huo, Pan Wu, Zhikun Zhang, Tao Wu, Hongmei Peng, Yong Huang, Yongxiang Zhao, Yulin Yuan, Zhiming Deng, Hongliang Tang
Summary: A bispecific T-cell engager antibody targeting human endoglin and CD3 was constructed in this study, showing therapeutic potential in cancer treatment. In vivo experiments demonstrated that the antibody significantly reduced tumor growth and neoangiogenesis, leading to improved mouse survival.
Article
Immunology
Alex Olvera, Samandhy Cedeno, Anuska Llano, Beatriz Mothe, Jorge Sanchez, Gemma Arsequell, Christian Brander
Summary: Post-translational protein modifications, particularly glycosylation, may impact T cell epitope recognition presented by HLA molecules, but this aspect has been overlooked in HIV research. Studies demonstrated that glycosylation can affect T cell recognition of viral peptides in individuals with chronic HIV infection, indicating the potential importance of glyco-epitope specific T cell immunity in understanding host immune responses against viral infections. New methodologies are needed to accurately assess the role of glycosylation in altering T cell immunity to viral infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Dingkang Liu, Lichen Bao, Haichao Zhu, Yali Yue, Jing Tian, Xiangdong Gao, Jun Yin
Summary: This study developed a Protease-Activated PSTAGylated BiTE called PAPB, which showed long-acting and highly effective anti-tumor activity in solid tumors. PAPB could release BiTE core to exert its therapeutic effect, and significantly increase T lymphocyte infiltration in tumor tissue. This engineered protein has potential as a promising drug candidate for solid tumor immunotherapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Virology
Isabelle M. Castro, Michael J. Ricciardi, Lucas Gonzalez-Nieto, Eva G. Rakasz, Jeffrey D. Lifson, Ronald C. Desrosiers, David Watkins, Mauricio A. Martins
Summary: This study tracks the long-term effects of an AIDS vaccine on rhesus macaques, showing sustained anti-SIV immune responses and successful protection against a second round of rectal SIV exposure. These findings are relevant for the development of HIV vaccines.
JOURNAL OF VIROLOGY
(2021)
Article
Oncology
Wei-Wei Zheng, Hang Zhou, Ping Li, Shi-Guang Ye, Tuersunayi Abudureheman, Li-Ting Yang, Kai Qing, Ai-Bin Liang, Kai-Ming Chen, Cai-Wen Duan
Summary: CD19 CAR-T cell immunotherapy achieves a remission rate of approximately 70% in recurrent and refractory lymphoma treatment. However, the loss or reduction of CD19 antigen on the surface of lymphoma cells results in the escape of tumor cells from the immune killing of CD19 CAR-T cells (CAR19-T). In this study, an anti-CD79b/CD3 bispecific antibody (BV28-OKT3) was constructed and combined with CAR19-T cells for B-cell lymphoma treatment, overcoming the escape of CD79b+ CD19- lymphoma cells by redirecting CAR19-T cells to these cells.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Virology
Sanath Kumar Janaka, Alexandra V. Palumbo, Aidin Tavakoli-Tameh, David T. Evans
Summary: The Nef proteins of HIV-1 and SIV enhance viral infectivity by preventing the incorporation of SERINC5 into virions. By systematically mapping Nef residues required for SERINC5 antagonism, it was found that separating this function allows comparison of replication in viruses that are or are not sensitive to SERINC5, revealing its impact on SIV replication in primary rhesus macaque CD4(+)T cells.
JOURNAL OF VIROLOGY
(2021)
Review
Immunology
Anna J. Jasinska, Ivona Pandrea, Cristian Apetrei
Summary: CCR5 is a chemokine receptor that plays a central role in immune responses and inflammation. It is involved in the pathogenesis of various health conditions, including HIV infection. Natural loss-of-function mutations of CCR5 can render individuals resistant to HIV. In addition, many African nonhuman primate species have developed strategies to minimize the effects of SIV infection by modulating CCR5 activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Alex S. Hartlage, Piyush Dravid, Christopher M. Walker, Amit Kapoor
Summary: The study found that the efficacy of an RHV T cell vaccine is reduced when challenge virus contains escape mutations within MHC class I-restricted epitopes. CD4 T cell help is a critical correlate of vaccine success against heterologous virus challenge. These results have important implications for human vaccination programs against heterogeneous HCV strains.
Article
Virology
Mark A. Pilkinton, Wyatt J. McDonnell, Louise Barnett, Abha Chopra, Rama Gangula, Katie D. White, Shay Leary, Jennifer Currenti, Silvana Gaudieri, Simon A. Mallal, Spyros A. Kalams
Summary: Cellular immune responses to Gag are associated with improved HIV control, with CD8(+) T cell response dominated by a few unique TCRs and CD4(+) T cell response displaying a more diverse TCR repertoire. Greater TCR diversity in CD4(+) T cells may limit HIV genetic diversity during chronic infection.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Sanath Kumar Janaka, Brian J. Snow, Ryan T. Behrens, David T. Evans
Summary: Tetherin is a protein that prevents viruses from detaching from infected cells by physically tethering them to cellular membranes. SIV Nef downmodulates simian tetherin to overcome this restriction in nonhuman primate hosts. In addition to counteracting tetherin, SIV Nef has a number of other functions, including downmodulating other proteins from the cell surface. Researchers have engineered an infectious molecular clone of SIV with substitutions in Nef that separate tetherin antagonism from other Nef functions. This study demonstrates the importance of tetherin antagonism for optimal replication of SIV in primary CD4(+) T cells.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Tingting Sun, Yingdan Wang, Peng Zou, Qimin Wang, Jiangyan Liu, Wanli Liu, Jinghe Huang, Fan Wu
Summary: The study constructed three different variants of M2e-specific monoclonal antibodies and found that IgG2a variant provided better protection against influenza virus. Additionally, the administration route and timing of administration were critical factors in determining the protective efficacy.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Oncology
Ashwathi Puravankara Menon, Beatriz Moreno, Daniel Meraviglia-Crivelli, Francesca Nonatelli, Helena Villanueva, Martin Barainka, Angelina Zheleva, Hisse M. van Santen, Fernando Pastor
Summary: CD3 complex is the first signal sensed by TCR of lymphocytes for activation, making it an attractive receptor to determine immune response fate. This article discusses the assembly of CD3-TCR complex and the approaches to harness CD3 activity for immunotherapy.
Review
Immunology
Quentin Le Hingrat, Irini Sereti, Alan L. Landay, Ivona Pandrea, Cristian Apetrei
Summary: CD4(+) T-cell depletion is a key feature of AIDS in both HIV and SIV infections, occurring early and being most significant at mucosal sites. The clinical outcome is associated with mucosal CD4(+) T-cell recovery during chronic infection, while immune activation and inflammation play critical roles in CD4(+) T-cell depletion.
FRONTIERS IN IMMUNOLOGY
(2021)