Article
Pharmacology & Pharmacy
Chunxia Chen, Shihai Yan, Zhirong Geng, Zhilin Wang
Summary: The HIF-1 alpha PHD inhibitor IOX2 improves the proliferation and migration of BMSCs by upregulating intracellular Ca2+ and decreasing ROS, thus promoting fracture healing.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Nicholas W. Kieran, Rahul Suresh, Marie-France Dorion, Adam MacDonald, Manon Blain, Dingke Wen, Shih-Chieh Fuh, Fari Ryan, Roberto J. Diaz, Jo Anne Stratton, Samuel K. Ludwin, Joshua A. Sonnen, Jack Antel, Luke M. Healy
Summary: This study investigated the expression levels of miR-210 in astrocytes under ischemic stroke and in vitro stress conditions, and found its association with the astrocytic response to disease and neuroprotection.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell & Tissue Engineering
De-Tian Jiang, Lei Tuo, Xiao Bai, Wei-Dong Bing, Qing-Xi Qu, Xin Zhao, Guang-Min Song, Yan-Wen Bi, Wen-Yu Sun
Summary: This study demonstrates that PGE1 can modulate the properties of MSCs by regulating the HIF pathway, thereby improving their therapeutic potential in PAH.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biology
Milica Mandic, Kaitlyn Flear, Pearl Qiu, Yihang K. Pan, Steve F. Perry, Kathleen M. Gilmour
Summary: HIF-1α is important for hypoxic survival in zebrafish, particularly in relation to their ability to perform aquatic surface respiration (ASR). When zebrafish are prevented from accessing the surface during severe hypoxia, their survival is significantly compromised. However, when they are allowed to access the surface, there is no difference in survival between wild-type and HIF-1α knockout fish. ASR mitigates the negative effects of HIF-1α loss, with knockouts initiating ASR at a higher oxygen concentration and performing ASR for longer than wild-types.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Masashi Ishikawa, Masae Iwasaki, Hailin Zhao, Junichi Saito, Cong Hu, Qizhe Sun, Atsuhiro Sakamoto, Daqing Ma
Summary: The study showed that sevoflurane and desflurane enhanced ovarian cancer cell malignancy by deactivating miRNAs and increasing HIF-1 alpha expression. Further research is needed to determine the translational value of these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Benjamin Koch, Alec Gessner, Samira Farmand, Dominik C. Fuhrmann, Andreas G. Chiocchetti, Ralf Schubert, Patrick C. Baer
Summary: This study characterized the mRNA and miR loading of extracellular vesicles (EVs) after hypoxic preconditioning, and investigated their effects on renal tubular epithelial cells. The results showed significant regulation of transcripts and small RNAs, and demonstrated the anti-inflammatory effect of EVs on epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Qi Zhang, Zhenzhen Han, Yanbo Zhu, Jingcheng Chen, Wei Li
Summary: Cancer stem cells (CSCs) play a decisive role in cancer recurrence, metastasis, and resistance to treatment. Hypoxia inducible factor-1 (HIF-1) is an important molecule in regulating CSC development under hypoxic conditions, but the specific mechanism is still unclear.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Yun Zhang, Guo-Xin Zhang, Li-Shuang Che, Shu-Han Shi, Yue-Ting Li
Summary: The expression of miR-212 was significantly increased in patients with renal interstitial fibrosis and UUO mice, and it was found to promote the progression of renal interstitial fibrosis by targeting HIF1AN.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Sanjay Kumar, Varsha Yadav, Namrta Sharma, Anshika Sethi
Summary: Transplanted stem cells into ischemic myocardium die due to unfavorable conditions. This study aims to understand the mechanism of cell cycle regulation in mesenchymal stem cells (MSC) for their survival and proliferation during repair processes. Hypoxamir-210-3p and cell cycle regulators were analyzed to determine their role in regulating cell proliferation under hypoxic conditions. Bone marrow-derived MSC (BM-MSC) showed increased proliferation under hypoxia, and miR-210-3p was found to play a key role in this process by regulating pAkt, p53, and p21.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Mairah T. Khan, Joely J. Irlam-Jones, Ronnie Rodrigues Pereira, Brian Lane, Helen R. Valentine, Kai Aragaki, Lars Dyrskjot, David J. McConkey, Peter J. Hoskin, Ananya Choudhury, Catharine M. L. West
Summary: A 14-miRNA hypoxia signature was derived and found to be prognostic for overall survival in bladder cancer patients, showing similar performance to a 24-gene mRNA signature. Combining the miRNA and mRNA signatures improved performance and identified patients who benefitted most from carbogen and nicotinamide with radiotherapy. Interaction tests also showed significance for local relapse-free survival.
BRITISH JOURNAL OF CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xinhai Lin, Haodong Wang, Tiantian Wu, Yaqin Zhu, Long Jiang
Summary: These findings suggest that exosomal miR-126 derived from SCAPs under hypoxia can enhance HUVEC angiogenesis by suppressing SPRED1 and activating the ERK signaling pathway.
Article
Biology
Xiaowei Zheng, Sampath Narayanan, Cheng Xu, Sofie Eliasson Angelstig, Jacob Grunler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A. Forsberg, Ao Zhang, Kerstin Brismar, Tomas A. Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
Summary: Excessive production of mitochondrial reactive oxygen species (ROS) in diabetes complications is mainly caused by impaired responses to hypoxia due to the inhibition of hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Restoring HIF-1 function can attenuate ROS overproduction, protect cells against apoptosis and renal injury in diabetes. These findings suggest that targeting HIF-1 repression could be a potential therapeutic strategy for diabetic complications.
Article
Plant Sciences
Aram Lee, Eunsik Yun, Woochul Chang, Jongmin Kim
JOURNAL OF GINSENG RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jiyun Lee, Chang Youn Lee, Jun-Hee Park, Hyang-Hee Seo, Sunhye Shin, Byeong-Wook Song, Il-Kwon Kim, Sang Woo Kim, Seahyoung Lee, Jong-Chul Park, Soyeon Lim, Ki-Chul Hwang
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Mu Seog Choe, Joong Sun Kim, Han Cheol Yeo, Chang Min Bae, Ho Jae Han, Kyungmin Baek, Woochul Chang, Kyung Seob Lim, Seung Pil Yun, In-Sik Shin, Min Young Lee
Article
Genetics & Heredity
Dansaem Lim, Jin Gu Cho, Eunsik Yun, Aram Lee, Hong-Yeoul Ryu, Young Joo Lee, Sukjoon Yoon, Woochul Chang, Myeong-Sok Lee, Byung Su Kwon, Jongmin Kim
Summary: Targeting tumor vasculature is an appealing strategy for cancer treatment, but the heterogeneous nature and complex mechanisms of tumor neovascularization present challenges. AXL receptor tyrosine kinase (AXL) has been identified as a key regulator of vasculogenic mimicry (VM) formation in breast cancer cells, with the miR-34a-AXL axis being critical for the regulation of VM formation and a potential therapeutic target for inhibiting tumor neovascularization.
Article
Biochemistry & Molecular Biology
Byeong-Wook Song, Chang Youn Lee, Ran Kim, Won Jung Kim, Hee Won Lee, Min Young Lee, Jongmin Kim, Jee-Yeong Jeong, Woochul Chang
Summary: Enhancing microRNA-210 activity has been shown to inhibit heart cell death, reduce fibrosis, and enhance heart cell regeneration, offering a new therapeutic approach for heart disease recovery.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Neurosciences
Chang Youn Lee, Sung-Ae Hyun, Moon Yi Ko, Hye Ryeong Kim, Jaerang Rho, Kee K. Kim, Woo-Yang Kim, Minhan Ka
Summary: Early-life exposure to bisphenol A (BPA) disrupts the self-renewal and differentiation of neural progenitors during cortical development, leading to reduced neuron number and increased glial cells in the cerebral cortex. Additionally, synaptic formation and transmission are suppressed in the cerebral cortex after maternal BPA exposure, resulting in behavioral deficits likely mediated by activating autophagy.
Article
Biochemistry & Molecular Biology
Chang Youn Lee, Seahyoung Lee, Seongtae Jeong, Jiyun Lee, Hyang-Hee Seo, Sunhye Shin, Jun-Hee Park, Byeong-Wook Song, Il-Kwon Kim, Jung-Won Choi, Sang Woo Kim, Gyoonhee Han, Soyeon Lim, Ki-Chul Hwang
Summary: The acute demise of transplanted stem cells compromises the efficacy of stem cell-based therapy for infarcted hearts. Pyroptosis has been identified as an important cell death mechanism in damaged hearts, and miRNA-762 has been found to regulate interleukin 1 beta production and subsequent pyroptosis, enhancing the survival of transplanted stem cells and improving heart function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yeongun Lee, So Hee Dho, Jiyeon Lee, Ji-Hyun Hwang, Minjung Kim, Won-Young Choi, Jin-Young Lee, Jongwon Lee, Woochul Chang, Min Young Lee, Jungmin Choi, Tae-You Kim, Lark Kyun Kim
Summary: A study has identified gene-specific alterations associated with worse outcomes in colorectal cancer patients through detecting patterns of DNA modification. The results could provide clinicians with an additional diagnostic tool and suggest the potential utility of performing such methylation profiling in other cancer types.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Chang Youn Lee, In Soo Ryu, Jin-Hyeob Ryu, Hyun-Jeong Cho
Summary: Alzheimer's disease is a progressive neurodegenerative disorder, with miRNAs playing a crucial role in its pathological processes. Limitations of current pharmaceutical therapies have led to research on miRNA-based next-generation therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Sung-Ae Hyun, Chang Youn Lee, Moon Yi Ko, Sun-Hwa Chon, Ye-Ji Kim, Jeong-Wook Seo, Kee K. Kim, Minhan Ka
Summary: Exposure to BPA in human induced pluripotent stem cell-derived cardiomyocytes alters cardiac function, affecting potential, channels, calcium transients, and increasing the risk of arrhythmia.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Byeong-Wook Song, Sejin Kim, Ran Kim, Seongtae Jeong, Hanbyeol Moon, Hojin Kim, Elena A. A. Vasileva, Natalia P. P. Mishchenko, Sergey A. A. Fedoreyev, Valentin A. A. Stonik, Min Young Lee, Jongmin Kim, Hyoung Kyu Kim, Jin Han, Woochul Chang
Summary: Endothelial-mesenchymal transition (EndMT) is a process in which endothelial cells transition into mesenchymal cells and induce fibrosis due to ischemic conditions in the heart. In this study, echinochrome A (EchA) was found to negatively regulate EndMT and reduce fibrosis in the myocardium. It was also shown to have anti-inflammatory and antioxidant effects, as well as improve mitochondrial dysfunction. Animal experiments confirmed the control of EndMT by EchA.
Review
Biochemistry & Molecular Biology
Byeong-Wook Song, Sekyung Oh, Woochul Chang
Summary: Regenerative medicine aims to restore damaged cell or tissue function through regeneration, repair, or replacement. Stem cells are crucial for regenerative medicine, as they can be used to promote responses to diseases and dysfunctions. Stem cell-derived extracellular vesicles (EVs) are a promising source that can enrich microRNAs (miRNAs) for disease therapy, overcoming current limitations of cell therapy agents.
Article
Biochemistry & Molecular Biology
Ran Kim, Byeong-Wook Song, Minji Kim, Won Jung Kim, Hee Won Lee, Min Young Lee, Jongmin Kim, Woochul Chang
Review
Biochemistry & Molecular Biology
Dansaem Lim, Yeojin Do, Byung Su Kwon, Woochul Chang, Myeong-Sok Lee, Jongmin Kim, Jin Gu Cho