期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 428, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2021.115696
关键词
Bisphenol-a (BPA); Cardiac dysfunction; hiPSC-CMs; Field potentials; Cardiac ion channels; Cardiac contraction
资金
- National Research Foundation of Korea [NRF-2019R1A2C1009006]
- Korea Institute of Toxicology [1711121221]
- Ministry of Food and Drug Safety [19182MFDS406]
Exposure to BPA in human induced pluripotent stem cell-derived cardiomyocytes alters cardiac function, affecting potential, channels, calcium transients, and increasing the risk of arrhythmia.
Bisphenol A (BPA) is a well-known endocrine-disrupting chemical that is widely used in a variety of products, including plastics, medical equipment and receipts. Hence, most people are exposed to BPA through the skin, via inhalation and via the digestive system, and such exposure has been linked to cardiovascular diseases including coronary artery disease, hypertension, atherosclerosis, and myocardial infarction. However, the underlying mechanisms of cardiac dysfunction caused by BPA remain poorly understood. In this study, we found that BPA exposure altered cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Acute BPA exposure in hiPSC-CMs resulted in reduced field potential, as measured by multielectrode array (MEA). Furthermore, we observed that BPA dose-dependently inhibited ICa, INa or IKr channels. In addition, BPA exposure dose-dependently inhibited calcium transients and contraction in hiPSC-CMs. Our findings suggest that BPA exposure leads to cardiac dysfunction and cardiac risk factors such as arrhythmia.
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