Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Peikun Xin, Shuyan Han, Jun Huang, Conglai Zhou, Jiayuan Zhang, Xinru You, Jun Wu
Summary: Chronic diabetic wounds, characterized by long-term high levels of oxidative stress and blood sugar, present the biggest challenge in wound healing research. Edible natural biomaterials rich in terpenes, phenols, and flavonoids have shown potential as efficient antioxidants. Okra extract, selected as the main component of a wound dressing, displayed robust antioxidant properties, reducing reactive oxygen species and promoting wound healing in diabetic rats.
CHINESE CHEMICAL LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Hyosuk Kim, Da Eun Kim, Geonhee Han, Nu Ri Lim, Eun Hye Kim, Yeongji Jang, Haeun Cho, Hochung Jang, Ki Hun Kim, Sun Hwa Kim, Yoosoo Yang
Summary: Wound healing is a complex process involving various biological events, requiring a multifaceted approach for successful transitions between different phases. Bovine milk extracellular vesicles have shown promising results in promoting wound healing, especially in enhancing fibroblast proliferation, angiogenesis, and tissue remodeling. Colostrum-derived milk EVs are particularly effective in promoting re-epithelialization, angiogenesis, and maintaining stability and efficacy even after freeze-drying procedures, showing great potential as anti-inflammatory therapeutics for cutaneous wounds.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Engineering, Biomedical
Shirin Nour, Rana Imani, G. Rasul Chaudhry, Ali Mohammad Sharifi
Summary: This article provides a comprehensive overview of current and emerging angiogenesis induction methods for skin regeneration, aiming to accelerate wound healing. These methods are classified into cell-based, growth factor-based, scaffold-based, and biological/chemical compound-based strategies. The advantages and disadvantages of these angiogenic strategies are discussed along with relevant research examples to demonstrate their potential in wound treatment.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Leifeng Lyu, Yuanqing Cai, Guangyang Zhang, Zhaopu Jing, Jialin Liang, Rupeng Zhang, Xiaoqian Dang, Chen Zhang
Summary: In this study, exosomes derived from M2 macrophages were found to promote angiogenesis by inhibiting PTEN expression and activating the AKT/mTOR pathway in HUVECs. Furthermore, in a mouse model, M2-EXO was shown to promote angiogenesis and regeneration. These findings suggest that M2-EXO may serve as a promising nanomedicine strategy for skin healing.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Peikun Xin, Shuyan Han, Jun Huang, Xinru You, Jun Wu
Summary: This study investigates the multifunctionality of soybean milk as a bioactive coating for wound healing. The results demonstrate that soybean milk exhibits good biocompatibility and biological activity, enhancing tissue remodeling and wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Peikun Xin, Shuyan Han, Jun Huang, Xinru You, Jun Wu
Summary: This study found that soybean milk as a bioactive coating has good potential for promoting wound healing. Soybean milk has antioxidation and tissue remodeling properties, effectively scavenges intracellular reactive oxygen species, enhances epithelial cell migration and angiogenesis, thereby accelerating wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Inseong Jung, Dokyung Jung, Zhao Zha, Jongwon Jeong, Soojeong Noh, Jiwon Shin, Jun-Kook Park, Kwang-Soo Kim, Youngtae Jeong, Jin Hur, Moon-Chang Baek, Sophia Diaz-Aguilar, Edith Aguilar, Martin Friedlander, Felicitas Bucher, Kyungmoo Yea
Summary: IFNG exhibits potent anti-angiogenic potential against VEGFa-induced angiogenesis by inhibiting proliferation, migration, and tube formation of HUVECs. Knockdown of STAT1 abolishes the inhibitory effect of IFNG on VEGFa-induced angiogenic processes. In a mouse model, IFNG shows strong anti-angiogenic efficacy without inducing functional side effects.
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang, Yur-Ren Kuo
Summary: The study revealed that FIR therapy could significantly accelerate diabetic wound healing, associated with suppressed inflammatory response, increased neovascularization, and tissue regeneration.
Article
Chemistry, Multidisciplinary
Wenfeng Li, Rui Qing, Haojie Zhang, Ziwei Wang, Yuhan Yuan, Lili Wang, Jia Deng, Bochu Wang, Shilei Hao
Summary: The study demonstrates the significant promise of trichocyte keratins in promoting wound healing, with distinct behaviors and advantages observed among different types. Transcriptomic analysis reveals the regulatory mechanisms of keratins in cell proliferation, migration, and blood vessel generation. These findings can contribute to the development and precision application of keratins.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Mario A. Martinez-Jimenez, Samuel Kolosovas-Machuca, Francisco Alcocer, Luis Carlos Ortiz-Dosal, Mariana C. Gonzalez-Grijalva, Gibran A. Delsol-Revuelta, Francisco I. Gaitan-Gaona, Francisco J. Valadez-Castillo, Jose L. Ramirez-GarciaLuna
Summary: The topical administration of insulin glargine appears to be safe and promotes wound healing and tissue repair in nondiabetic patients with chronic venous ulcers.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Surgery
Punam P. Parikh, Diego Castilla, Roberta M. Lassance-Soares, Hongwei Shao, Manuela Regueiro, Yan Li, Roberto Vazquez-Padron, Keith A. Webster, Zhao-Jun Liu, Omaida C. Velazquez
ANNALS OF VASCULAR SURGERY
(2018)
Article
Surgery
Punam P. Parikh, Roberta M. Lassance-Soares, Hongwei Shao, Manuela M. Regueiro, Zhao-Jun Liu, Omaida C. Velazquez
JOURNAL OF SURGICAL RESEARCH
(2018)
Article
Genetics & Heredity
Wenjun Liu, Guanying Wang, Anna Palovcak, Yan Li, Sophie Hao, Zhao-Jun Liu, Ralf Landgraf, Fenghua Yuan, Yanbin Zhang
Article
Cell & Tissue Engineering
Yan Du, Hongwei Shao, Mecker Moller, Rochelle Prokupets, Yee Ting Tse, Zhao-Jun Liu
Article
Cardiac & Cardiovascular Systems
Lei Song, Zachary M. Zigmond, Laisel Martinez, Roberta M. Lassance-Soares, Alejandro E. Macias, Omaida C. Velazquez, Zhao-Jun Liu, Alghidak Salama, Keith A. Webster, Roberto Vazquez-Padron
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Hongwei Shao, Mecker Moller, Dazhi Wang, Albert Ting, Marcia Boulina, Zhao-Jun Liu
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Review
Cell & Tissue Engineering
Khaja Syed, Sara Naguib, Zhao-Jun Liu, Luisa Cimmino, Feng-Chun Yang
STEM CELL RESEARCH & THERAPY
(2020)
Article
Multidisciplinary Sciences
Hongwei Shao, Mecker Moller, Long Cai, Rochelle Prokupets, Cuixia Yang, Connor Costa, Kerstin Yu, Nga Le, Zhao-Jun Liu
Summary: The study indicates that the Notch signaling is inhibited in melanoma-associated fibroblasts (MAFs), and increasing Notch pathway activity can confer tumor-suppressive function on MAFs. Targeting melanoma by activating Notch signaling in MAFs may represent a novel therapeutic approach.
Article
Multidisciplinary Sciences
Antoine J. Ribieras, Yulexi Y. Ortiz, Sophie Shrestha, C. Theodore Huerta, Hongwei Shao, Maria E. Boulina, Roberto Vazquez-Padron, Zhao-Jun Liu, Omaida C. Velazquez
Summary: Peripheral arterial disease (PAD) is a significant disease resulting from atherosclerotic risk factors. This study focuses on a unique method to induce footpad gangrene in mice that resembles chronic limb-threatening ischemia (CLTI), which is the most severe form of PAD. The method combines femoral artery and vein electrocoagulation with the administration of a nitric oxide synthase (NOS) inhibitor. The study also introduces a novel approach using intracardiac perfusion and whole-mount confocal laser scanning microscopy to assess reperfusion.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Cardiac & Cardiovascular Systems
Antoine J. Ribieras, Yulexi Y. Ortiz, Yan Li, Carlos T. Huerta, Nga Le, Hongwei Shao, Roberto I. Vazquez-Padron, Zhao-Jun Liu, Omaida C. Velazquez
Summary: In patients with chronic limb-threatening ischemia and limited revascularization options, gene therapy using E-selectin/AAV2/2 shows promise in improving limb perfusion and function by reducing gangrene severity and enhancing angiogenesis and endothelial progenitor cell recruitment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Dermatology
Carlos Theodore Huerta, Yulexi Y. Ortiz, Zhao-Jun Liu, Omaida C. Velazquez
Summary: Given their capacity for self-renewal, multilineage differentiation, and immunomodulatory potential, mesenchymal stem cells (MSCs) represent a promising modality of clinical therapy for both regenerative medicine and immune diseases. In this study, we review the key approaches and popular methods utilized to boost potency and modify functions of MSCs for clinical purposes as well as their associated limitations.
ADVANCES IN WOUND CARE
(2023)
Review
Cardiac & Cardiovascular Systems
Carlos Theodore Huerta, Francesca A. Voza, Yulexi Y. Ortiz, Zhao-Jun Liu, Omaida C. Velazquez
Summary: Progressive peripheral arterial disease (PAD) can lead to chronic limb-threatening ischemia (CLTI), resulting in non-healing wounds and tissue loss. Current therapies for CLTI, such as revascularization and medical management, have limitations, and regenerative therapies utilizing mesenchymal stem/stromal cells (MSCs) hold promise in improving wound healing and limb salvage. In this review, we focus on the specific effects of MSC-based therapeutics on ischemic non-healing wounds associated with CLTI, providing insights from pre-clinical and clinical studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Antoine J. Ribieras, Yulexi Y. Ortiz, Yan Li, Nga T. Le, Carlos T. Huerta, Francesca A. Voza, Hongwei Shao, Roberto I. Vazquez-Padron, Zhao-Jun Liu, Omaida C. Velazquez
Summary: This study evaluated the effects of E-selectin gene therapy on skeletal muscle recovery, specifically focusing on exercise performance and myofiber regeneration. The results showed that mice treated with E-selectin gene therapy had improved hindlimb perfusion, exercise capacity, and enhanced regeneration of ischemic skeletal muscle. These findings suggest a potential role for E-selectin gene therapy as a nonsurgical adjunct in patients with peripheral artery disease.
CARDIOVASCULAR THERAPEUTICS
(2023)
Article
Biology
Hongwei Shao, Yan Li, Irena Pastar, Min Xiao, Rochelle Prokupets, Sophia Liu, Kerstin Yu, Roberto Vazquez-Padron, Marjana Tomic-Canic, Omaida C. Velazquez, Zhao-Jun Liu
LIFE SCIENCE ALLIANCE
(2020)
Article
Oncology
Sushmita Mustafi, Vladimir Camarena, Claude-Henry Volmar, Tyler C. Huff, David W. Sant, Shaun P. Brothers, Zhao-Jun Liu, Claes Wahlestedt, Gaofeng Wang