Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

(2015) Nathaniel Washburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 attenuates the development of experimental autoimmune uveitis

(2014) Mark Barbour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Broad requirement for terminal sialic acid residues and FcγRIIB for the preventive and therapeutic activity of intravenous immunoglobulins in vivo

(2014) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Therapeutic Effect of IVIG on Inflammatory Arthritis in Mice Is Dependent on the Fc Portion and Independent of Sialylation or Basophils

(2014) I. K. Campbell et al.   JOURNAL OF IMMUNOLOGY

IL-33 Is an Unconventional Alarmin That Stimulates IL-2 Secretion by Dendritic Cells To Selectively Expand IL-33R/ST2+Regulatory T Cells

(2014) Benjamin M. Matta et al.   JOURNAL OF IMMUNOLOGY

Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins

(2014) Alysia A. Ahmed et al.   JOURNAL OF MOLECULAR BIOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Intravenous immunoglobulin-induced IL-33 is insufficient to mediate basophil expansion in autoimmune patients

(2014) Meenu Sharma et al.   Scientific Reports

Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells

(2013) Amir H. Massoud et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell–independent B cell activation induces immunosuppressive sialylated IgG antibodies

(2013) Constanze Hess et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

(2013) Xiaojie Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

General mechanism for modulating immunoglobulin effector function

(2013) P. Sondermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel roles for the IgG Fc glycan

(2012) Robert M. Anthony et al.   Annals of the New York Academy of Sciences

Tregitope update: Mechanism of action parallels IVIg

(2012) Leslie P. Cousens et al.   AUTOIMMUNITY REVIEWS

IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages

(2012) Hui-Rong Jiang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3–positive regulatory T cells

(2012) Amir H. Massoud et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

(2012) Leslie P. Cousens et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Intravenous Immunoglobulin Expands Regulatory T Cells in Autoimmune Rheumatic Disease

(2012) J. BAYRY et al.   JOURNAL OF RHEUMATOLOGY

Analysis and Functional Consequences of Increased Fab-Sialylation of Intravenous Immunoglobulin (IVIG) after Lectin Fractionation

(2012) Fabian Käsermann et al.   PLoS One

The role of sialic acid as a modulator of the anti-inflammatory activity of IgG

(2012) Sybille Böhm et al.   Seminars in Immunopathology

Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin

(2012) Danila Leontyev et al.   TRANSFUSION

IL-33 Expands Suppressive CD11b+ Gr-1int and Regulatory T Cells, including ST2L+ Foxp3+ Cells, and Mediates Regulatory T Cell-Dependent Promotion of Cardiac Allograft Survival

(2011) H. R. Turnquist et al.   JOURNAL OF IMMUNOLOGY

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Interleukin-33 prolongs allograft survival during chronic cardiac rejection

(2011) Stefan M. Brunner et al.   TRANSPLANT INTERNATIONAL

Antibody-mediated modulation of immune responses

(2010) Falk Nimmerjahn et al.   IMMUNOLOGICAL REVIEWS

A Novel Role for the IgG Fc Glycan: The Anti-inflammatory Activity of Sialylated IgG Fcs

(2010) Robert M. Anthony et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation

(2010) A. Jäger et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

In vivodepletion of CD4+FOXP3+Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcγRIII+phagocytes

(2009) Yulius Y. Setiady et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impaired inhibitory Fc  receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy

(2009) B. Tackenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

Identification of a receptor required for the anti-inflammatory activity of IVIG

(2008) R. M. Anthony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis

(2007) A. Ephrem et al.   BLOOD