Article
Multidisciplinary Sciences
Barbara Spix, Elisabeth S. Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Gunes Gunsel, Thomas M. Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M. Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime Garcia-Anoveros, Paul Saftig, Martin Giera, Sebastian Kobold, Herbert B. Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Oender Yildirim, Martin Biel, Christian Grimm
Summary: The study reveals TRPML3 as a key regulator of MMP-12 clearance by alveolar macrophages, suggesting it as a therapeutic target for emphysema and chronic obstructive pulmonary disease.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Omar A. Elkady, Layla M. Saleh, Mina Ibrahim Tadros, Hanan M. El-laithy
Summary: Risedronate sodium is a potent drug known for inducing osteoclast apoptosis. This study investigated the potential of nebulizable RS-chitosan microspheres to induce alveolar macrophage apoptosis, showing promise in attenuating pulmonary emphysema.
Review
Cell Biology
Chih-Ru Lin, Karim Bahmed, Beata Kosmider
Summary: Alveolar type II cells play a crucial role in repairing the alveolar epithelium and maintaining lung homeostasis. Various signaling pathways, including WNT/beta-catenin, YAP/TAZ, NOTCH, TGF-beta, and P53, are involved in the proliferation and differentiation of these cells. Imbalance in cell death and proliferation contributes to pathogenesis of pulmonary emphysema. Cigarette smoking induces oxidative stress, leading to inflammation and dysfunction of alveolar type II cells.
Article
Immunology
Lijuan Jiang, Xiaoxiao Han, Wenlin Qiu, Tong Yu, Ruizhi Feng, Xuefei Wang, Xiaoru Duan, Guo-Min Deng
Summary: This study investigated the role of CD64 in SLE patients and animal models. The results showed that CD64 expression was increased in SLE patients and correlated with SLE progression and related indicators. In animal models, CD64 was associated with lupus pathogenesis and played a regulatory role in skin inflammation induced by lupus serum.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Marija Gredic, Vinita Sharma, Stefan Hadzic, Cheng-Yu Wu, Oleg Pak, Baktybek Kojonazarov, Julia Duerr, Marcus A. A. Mall, Andreas Guenther, Ralph T. T. Schermuly, Friedrich Grimminger, Werner Seeger, Simone Kraut, Natascha Sommer, Norbert Weissmann
Summary: This study aimed to investigate the effect of iNOS gene deletion on elastase-induced emphysema in mice. The results showed that iNOS gene deletion did not produce significant therapeutic effects on elastase-induced lung emphysema and pulmonary hypertension. Therefore, this study suggests that iNOS expression in pulmonary vascular or stromal cells might play a critical role in lung regeneration in emphysema.
Article
Food Science & Technology
Yen-Chang Chen, Yu-Kai Cheng, Jia-Hong Chen, Cheng-Fang Tsai, Tsung-Kai Wang, Chen-Yun Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: This research investigates the effects of cardamonin on pulmonary inflammation. The results suggest that cardamonin has anti-inflammatory and anti-oxidative properties against PMA-induced pulmonary inflammation. It activates the Nrf2/HO-1 axis and reduces pro-inflammatory responses in alveolar macrophages.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eliza Mathias Melo, Vivian Louise Soares Oliveira, Daiane Boff, Izabela Galvao
Summary: Macrophages are a heterogeneous population of myeloid cells with diverse functions in the lung, where they are distributed in different compartments and can have both protective and damaging effects. Their phenotype and function are modulated by the microenvironment, allowing for responses to various stimuli such as inflammation or infection.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Immunology
Hui Wang, Chuan-Shan Zhang, Bin-Bin Fang, Jiao Hou, Wen-Ding Li, Zhi-De Li, Liang Li, Xiao-Juan Bi, Liang Li, Abuduaini Abulizi, Ying-Mei Shao, Ren-Yong Lin, Hao Wen
Summary: The study reveals that M2 macrophages dominate in hepatic macrophages associated with E. multilocularis infection. Macrophages in the liver tend to polarize towards the M1 phenotype at the early stage of infection, then shift to the M2 phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Cormac McCarthy, Brenna C. Carey, Bruce C. Trapnell
Summary: Autoimmune pulmonary alveolar proteinosis is a rare disease characterized by dysfunction of myeloid cells, abnormal accumulation of pulmonary surfactant, and innate immune deficiency. Research has brought this disease from obscurity to a paradigm of molecular pathogenesis-based diagnosis and treatment. The low prevalence and nonspecific symptoms make diagnosis challenging and delay accurate treatment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Engineering, Biomedical
Tao Chen, Zhaowenbin Zhang, Dong Weng, LiQin Lu, XiaoYa Wang, Min Xing, Hui Qiu, MengMeng Zhao, Li Shen, Ying Zhou, Jiang Chang, Hui-Ping Li
Summary: The study proposed an ion therapy approach based on bioactive ions of bioceramic materials, which significantly reduced pulmonary fibrosis by regulating the functions of AEC2 and macrophages. This suggests a potential clinical application of ion therapy for lung fibrosis.
BIOACTIVE MATERIALS
(2021)
Article
Cell Biology
Takae Tanosaki, Yu Mikami, Hideo Shindou, Tomoyuki Suzuki, Tomomi Hashidate-Yoshida, Keisuke Hosoki, Shizuko Kagawa, Jun Miyata, Hiroki Kabata, Katsunori Masaki, Ryuji Hamamoto, Hidenori Kage, Naoya Miyashita, Kosuke Makita, Hirotaka Matsuzaki, Yusuke Suzuki, Akihisa Mitani, Takahide Nagase, Takao Shimizu, Koichi Fukunaga
Summary: This study investigated the role of LPCAT1 in the pathology of COPD. The findings showed that mice with Lpcat1 gene knockout had significantly worsened elastase-induced emphysema, which was not improved by supplementing with surfactant that is mainly synthesized by LPCAT1. Additionally, cigarette smoke extract was found to downregulate the expression of LPCAT1 in human lung cells and induce apoptosis. These results suggest that the downregulation of LPCAT1 by cigarette smoke may contribute to the exacerbation of pulmonary emphysema through increasing the susceptibility of alveolar epithelial cells to apoptosis, highlighting LPCAT1 as a potential therapeutic target for irreversible emphysema.
Article
Biochemistry & Molecular Biology
Natalia Pereira da Silva Araujo, Natalia Alves de Matos, Michel Oliveira, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Pedro Alves Machado-Junior, Debora Maria Soares de Souza, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and mortality worldwide, with cigarette smoke playing a key role in its development. Quercetin may have potential as a preventive agent for smoke-induced pulmonary emphysema.
Article
Pharmacology & Pharmacy
Jianlong Zhang, Chong Liu, Guangrong Zhao, Meng Li, Di Ma, Qingguo Meng, Wenli Tang, Qingrong Huang, Peimin Shi, Youzhi Li, Linlin Jiang, Xin Yu, Hongwei Zhu, Guozhong Chen, Xingxiao Zhang
Summary: The synergistic effect of high concentrations of PM2.5 and P. aeruginosa in enclosed broiler houses impairs the function of alveolar macrophages and leads to inflammation, with the activation of the mTOR signaling pathway playing a crucial role.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Mengyao Li, Wentao Zhang, Jing Zhang, Xiaowei Li, Fujun Zhang, Wenhua Zhu, Liesu Meng, Rikard Holmdahl, Shemin Lu
Summary: Ncf1 deficiency enhances Th1 response, deactivates ILC2, and protects against pulmonitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Physiology
Stephen E. McGowan
Summary: The extracellular matrix (ECM) and cells in the pulmonary parenchyma need to adapt to changes in shape and maintain their attachment during respiration. DDR2, along with collagen-binding integrins, regulates focal adhesion formation and the response of lung fibroblasts to ECM rigidity. DDR2 deletion leads to reduced rigidity sensing and mechano-responsiveness, contributing to the distortion of alveolar ducts.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Chemistry, Medicinal
Bin Cai, James S. Panek, Salomon Amar
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Immunology
Olivier Huck, Jian You, Xianxian Han, Bin Cai, James Panek, Salomon Amar
INFECTION AND IMMUNITY
(2018)
Review
Cardiac & Cardiovascular Systems
Peter Libby, Joseph Loscalzo, Paul M. Ridker, Michael E. Farkouh, Priscilla Y. Hsue, Valentin Fuster, Ahmed A. Hasan, Salomon Amar
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Immunology
Emer P. Reeves, Danielle M. Dunlea, Karen McQuillan, Ciara A. O'Dwyer, Tomas P. Carroll, Radka Saldova, Prithvi Reddy Akepati, Mark R. Wormald, Oliver J. McElvaney, Vipatsorn Shutchaidat, Michael Henry, Paula Meleady, Joanne Keenan, Derek C. Liberti, Darrell N. Kotton, Pauline M. Rudd, Andrew A. Wilson, Noel G. McElvaney
JOURNAL OF IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Olivier Huck, Xiaxian Han, Hannah Mulhall, Iryna Gumenchuk, Bin Cai, James Panek, Radha Iyer, Salomon Amar
SCIENTIFIC REPORTS
(2019)
Article
Cell & Tissue Engineering
Killian Hurley, Jun Ding, Carlos Villacorta-Martin, Michael J. Herriges, Anjali Jacob, Marall Vedaie, Konstantinos D. Alysandratos, Yuliang L. Sun, Chieh Lin, Rhiannon B. Werder, Jessie Huang, Andrew A. Wilson, Aditya Mithal, Gustavo Mostoslavsky, Irene Oglesby, Ignacio S. Caballero, Susan H. Guttentag, Farida Ahangari, Naftali Kaminski, Alejo Rodriguez-Fraticelli, Fernando Camargo, Ziv Bar-Joseph, Darrell N. Kotton
Article
Dentistry, Oral Surgery & Medicine
Olivier Huck, Hannah Mulhall, George Rubin, Zev Kizelnik, Radha Iyer, John D. Perpich, Nasreen Haque, Patrice D. Cani, Willem M. de Vos, Salomon Amar
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Article
Immunology
Hannah Mulhall, Jeanne M. DiChiara, Matthew Deragon, Radha Iyer, Olivier Huck, Salomon Amar
Summary: The study indicates that Akkermansia muciniphila and its pili-like protein Amuc_1100 have potential therapeutic interest in managing periodontitis by reducing alveolar bone loss and promoting anti-inflammatory effects. This is achieved through inducing a proresolutive phenotype of macrophages and increasing expression of interleukin 10 in gingival tissues.
INFECTION AND IMMUNITY
(2021)
Article
Hematology
Anthony K. Yeung, Carlos Villacorta-Martin, Stephanie Hon, Jason R. Rock, George J. Murphy
Letter
Dentistry, Oral Surgery & Medicine
Olivier Huck, Hannah Mulhall, George Rubin, Zev Kizelnik, Radha Iyer, John D. Perpich, Nasreen Haque, Patrice D. Cani, Willem M. de Vos, Salomon Amar
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shou-Wen Wang, Michael J. Herriges, Kilian Hurley, Darrell N. Kotton, Allon M. Klein
Summary: The goal of single-cell genome-wide profiling is to reconstruct dynamic transitions during cell differentiation, disease onset, and drug response. In this study, a robust computational approach called CoSpar was developed to infer cell dynamics from single-cell transcriptomics integrated with lineage tracing. CoSpar identified previously undiscovered early fate biases and predicted key factors involved in fate choice.
NATURE BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Kim Vanuytsel, Anthony K. Yeung, Todd W. Dowrey, George J. Murphy, Anna C. Belkina
Summary: Hematopoietic stem cells have the ability to produce all mature blood cell types and maintain their population through self-renewing divisions. A multi-parameter spectral flow cytometry panel has been developed to better characterize HSC and their downstream progeny. In this study, this panel is used to comprehensively profile the HSC compartment in fetal liver.
Editorial Material
Surgery
Catherine A. A. Lee, Diana Wang, Martin Kauke-Navarro, Eleanor Russell-Goldman, Shuyun Xu, Kyla N. Mucciarone, Sadaf Sohrabi, Christine G. Lian, Bohdan Pomahac, George F. Murphy
Summary: This study evaluated the immunoproteomic profile of a full facial vascularized composite allograft (VCA) removed 88 months after transplantation. The results showed that CD8-positive T cells from the donor infiltrated the intragraft arteries and interacted with the degenerating endothelium of the recipient. Proteomic analysis revealed proteins expressed by activated cytotoxic T cells and macrophages, as well as pathway components involved in the development of arteriosclerosis. This suggests that chronic rejection of facial VCAs involves an accelerated arteriosclerosis process mediated by persistent graft-resident effector T cells and recipient target endothelium.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Pharmacology & Pharmacy
Martin H. Steinberg, Sara Kumar, George J. Murphy, Kim Vanuytsel
EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT
(2019)
Article
Hematology
Kim Vanuytsel, Taylor Matte, Amy Leung, Zaw Htut Naing, Tasha Morrison, David H. K. Chui, Martin H. Steinberg, George J. Murphy