Epigenetic control of intestinal barrier function and inflammation in zebrafish

UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma

(2014) Raksha Mudbhary et al.   CANCER CELL

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

(2014) Raquel Espín-Palazón et al.   CELL

Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling

(2014) A. L. Alvers et al.   DEVELOPMENT

DNA methylation is required for the control of stem cell differentiation in the small intestine

(2014) K. L. Sheaffer et al.   GENES & DEVELOPMENT

The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

(2014) Yuuki Obata et al.   NATURE IMMUNOLOGY

Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish

(2013) S. Ryan et al.   DEVELOPMENT

Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish

(2013) A. Navis et al.   DEVELOPMENT

Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

(2013) Nicholas T. Ventham et al.   GASTROENTEROLOGY

DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis

(2013) S. Georgia et al.   GENES & DEVELOPMENT

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

(2013) Atsuya Nishiyama et al.   NATURE

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

(2013) Theresa Alenghat et al.   NATURE

Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

(2013) Kevin Takaki et al.   Nature Protocols

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

From genetics of inflammatory bowel disease towards mechanistic insights

(2013) Daniel B. Graham et al.   TRENDS IN IMMUNOLOGY

Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages

(2012) Chao-Tsung Yang et al.   Cell Host & Microbe

Epigenetics in inflammatory bowel disease

(2012) Andreas C. Jenke et al.   CURRENT OPINION IN GASTROENTEROLOGY

Glafenine-induced intestinal injury in zebrafish is ameliorated by  -opioid signaling via enhancement of Atf6-dependent cellular stress responses

(2012) J. R. Goldsmith et al.   Disease Models & Mechanisms

TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3

(2012) R. Espin et al.   Disease Models & Mechanisms

Mutation mapping and identification by whole-genome sequencing

(2012) I. Leshchiner et al.   GENOME RESEARCH

Epigenetics: Concepts and relevance to IBD pathogenesis

(2012) Melania Scarpa et al.   INFLAMMATORY BOWEL DISEASES

Mucosal genome-wide methylation changes in inflammatory bowel disease

(2012) James Cooke et al.   INFLAMMATORY BOWEL DISEASES

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Age-related loss of CpG methylation in the tumour necrosis factor promoter

(2011) Isobel R. Gowers et al.   CYTOKINE

Microbial Colonization Induces Dynamic Temporal and Spatial Patterns of NF-κB Activation in the Zebrafish Digestive Tract

(2011) Michelle Kanther et al.   GASTROENTEROLOGY

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter

(2011) Han Han et al.   HUMAN MOLECULAR GENETICS

Genome-wide methylation profiling in Crohnʼs disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway

(2011) Elaine R. Nimmo et al.   INFLAMMATORY BOWEL DISEASES

UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis

(2011) Jaime Chu et al.   MOLECULAR BIOLOGY OF THE CELL

Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis

(2011) Azucena López-Muñoz et al.   MOLECULAR IMMUNOLOGY

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

(2011) M. Roulis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens

(2010) Rachel K. Tittle et al.   DEVELOPMENTAL BIOLOGY

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

TNF -dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

(2009) R. P. Matthews et al.   DEVELOPMENT

Methods for generating and colonizing gnotobiotic zebrafish

(2008) Linh N Pham et al.   Nature Protocols

QUMA: quantification tool for methylation analysis

(2008) Y. Kumaki et al.   NUCLEIC ACIDS RESEARCH