NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial

(2012) Lori Berk et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2R null mice engrafted with human peripheral blood mononuclear cells

(2012) T. Nolte et al.   Disease Models & Mechanisms

A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies

(2012) Vipra Dhir et al.   Journal of Immunotoxicology

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412

(2011) P. S. Romer et al.   BLOOD

Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

(2011) Jiuping Ji et al.   PLoS One

The Oncogenic BRAF Kinase Inhibitor PLX4032/RG7204 Does Not Affect the Viability or Function of Human Lymphocytes across a Wide Range of Concentrations

(2010) B. Comin-Anduix et al.   CLINICAL CANCER RESEARCH

Interleukin 4 or Cytokine Antagonists? Time to Change the Search for Novel Psoriasis Therapies

(2010) Martin Röcken   DERMATOLOGY

Human Pharmacokinetics/Pharmacodynamics of an Interleukin-4 and Interleukin-13 Dual Antagonist in Asthma

(2009) Elise Burmeister Getz et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Differential Regulation of IL-4R  Expression by Antigen versus Cytokine Stimulation Characterizes Th2 Progression In Vivo

(2009) G. Perona-Wright et al.   JOURNAL OF IMMUNOLOGY

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings concomitantly with activation-induced cytidine deaminase expression and differentiation into plasma cells

(2008) Shinji Kobayashi et al.   HUMAN IMMUNOLOGY

Characterization of a Hapten-Induced, Murine Model with Multiple Features of Atopic Dermatitis: Structural, Immunologic, and Biochemical Changes following Single Versus Multiple Oxazolone Challenges

(2007) Mao-Qiang Man et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY